Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-24T02:56:33.766Z Has data issue: false hasContentIssue false
  • English
  • Français

Two-locus Linkage Analysis Applied to Putative Quantitative Trait Loci for Lipoprotein(a) Levels

Published online by Cambridge University Press:  21 February 2012

Marian Beekman ,
Bastiaan T. Heijmans ,
Nicholas G. Martin ,
John B. Whitfield ,
Nancy L. Pedersen ,
Ulf DeFaire ,
Harold Snieder ,
Nico Lakenberg ,
Peter de Knijff  and
Rune R. Frants
...Show all authors
Marian Beekman*
Affiliation:
Section of Molecular Epidemiology, Leiden University Medical Center, Leiden,The Netherlands. M.Beekman@lumc.nl
Bastiaan T. Heijmans
Affiliation:
Section of Molecular Epidemiology, Leiden University Medical Center, Leiden,The Netherlands.
Nicholas G. Martin
Affiliation:
Queensland Institute for Medical Research, Brisbane, Australia.
John B. Whitfield
Affiliation:
Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Sydney, Australia.
Nancy L. Pedersen
Affiliation:
Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden.
Ulf DeFaire
Affiliation:
Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Harold Snieder
Affiliation:
Twin Research & Genetic Epidemiology Unit, St.Thomas' Hospital, London, United Kingdom; Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia,Augusta, United States of America.
Nico Lakenberg
Affiliation:
Section of Molecular Epidemiology, Leiden University Medical Center, Leiden,The Netherlands.
Peter de Knijff
Affiliation:
Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden,The Netherlands.
Rune R. Frants
Affiliation:
Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden,The Netherlands.
Gert Jan B. van Ommen
Affiliation:
Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden,The Netherlands.
Cornelis Kluft
Affiliation:
Department of Vascular and Connective Tissue Research,TNO Prevention and Health, Leiden,The Netherlands.
George P. Vogler
Affiliation:
Department of Biobehavioral Health, Center for Developmental and Health Genetics, Pennsylvania State University, University Park, Pennsylvania, United States of America.
P. Eline Slagboom
Affiliation:
Section of Molecular Epidemiology, Leiden University Medical Center, Leiden,The Netherlands.
Dorret I. Boomsma
Affiliation:
Department of Biological Psychology, Free University of Amsterdam,Amsterdam,The Netherlands.
*
*Address for correspondence: Marian Beekman, Section of Molecular Epidemiology, Leiden University Medical Center, PO Box 9503, 2300 RA, Leiden, The Netherlands.

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Plasma levels of lipoprotein(a) — Lp(a) — are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs.

Type
Articles
Information
Twin Research and Human Genetics , Volume 6 , Issue 4 , 01 August 2003 , pp. 322 - 324
Copyright
Copyright © Cambridge University Press 2003