Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-03T12:04:57.115Z Has data issue: false hasContentIssue false
  • English
  • Français

Red/green opponency in the rhesus macaque ERG spectral sensitivity is reduced by bicuculline

Published online by Cambridge University Press:  02 June 2009

Stephen L. Mills  and
Harry G. Sperling
Stephen L. Mills
Affiliation:
Sensory Sciences Center, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston
Harry G. Sperling
Affiliation:
Sensory Sciences Center, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston
Get access Rights & Permissions [Opens in a new window]

Abstract

Spectral-sensitivity curves were derived from the a−, b−, and d−waves of rhesus monkey ERGs after injection of bicuculline, strychnine, or no drug. Without drug injection, the a− and d−wave curves were well-fit by an additive model of weighted photoreceptor absorption spectra, while the b−wave curve requires inhibitory terms to produce an adequate fit. Bicuculline, but not strychnine, reduced the weight assigned to the inhibitory terms in a dose-dependent fashion, to the point that no inhibition was evident. The results suggest that GABAergic synapses are required for the expression of red/green color opponency in primate bipolar cells.

Keywords

BicucullineRhesus macaquePhotoreceptor absorption spectraERG spectral sensitivityBipolar cells
Type
Research Article
Information
Visual Neuroscience , Volume 5 , Issue 3 , September 1990 , pp. 217 - 221
Copyright
Copyright © Cambridge University Press 1990

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Boycott, B.B., Hopkins, J.M. & Sperling, H.G. (1987). Cone connections of the horizontal cells of the rhesus monkey's retina. Proceedings of the Royal Society B (London) 229, 345–379.Google ScholarPubMed
Brandon, C. (1985). Retinal GABA neurons: localization in vertebrate species using an antiserum to rabbit brain glutamate decarboxylase. Brain Research 344, 286–295.CrossRefGoogle ScholarPubMed
Dick, E., Miller, R.F.& Bloomfield, S. (1985). Extracellular K+ activity changes related to electroretinogram components, II: Rabbit (E-type) retinas. Journal of General Physiology 85, 911–931.CrossRefGoogle ScholarPubMed
Dick, E., Miller, R.F. & Dacheux, R.F. (1979). Neuronal origin of b− and d−waves in the I-type ERG. Investigations in Ophthalmology and Visual Science (ARVO Suppl.) 18, 34,Google Scholar
Gottlob, I., Wundsch, L. & Tuppy, F.K. (1988). The rabbit electroretinogram: effect of GABA and its antagonists. Vision Research 28, 203.CrossRefGoogle ScholarPubMed
Heynen, H. & Van, Norren D. (1985). Origin of the electroretinogram in the intact macaque eye, II: Current source density analysis. Vision Research 25, 709–716.CrossRefGoogle ScholarPubMed
Mariani, A.P. & Caserta, M.T.. (1986). Electron microscopy of glutamate decarboxylase (GAD) immunoreactivity in the inner plexiform layer of the rhesus monkey retina. Journal of Neurocytology 15, 645 –655.CrossRefGoogle ScholarPubMed
Mollon, J.D.& Polden, P.G. (1977). An anomaly in the response of the eye to light of short wavelengths. Philosophical Transactions of the Royal Society B 278, 207–240.Google ScholarPubMed
Neal, M.J. & Massey, S.C. (1980). The release of acetylcholine and amino acids from the rabbit retina in vivo. Neurochemistry International 1, 191–208.CrossRefGoogle Scholar
Redburn, D. & Madtes, P. Jr, (1986). Postnatal development of [3H]-GABA-accumulating cells in rabbit retina. Journal of Comparative Neurology 243, 41–65.CrossRefGoogle ScholarPubMed
Sarthy, P.J. & Fu, M. (1989). Localization of L-glutamic acid decarboxylase mRNA in monkey and human retina by in situ hybridization. Journal of Comparative Neurology 288, 691–697.CrossRefGoogle ScholarPubMed
Schuurmans, R.P. & Zrenner, E. (1981). Responses of the blue sensitive cone system from the visual cortex and the arterially perfused eye in cat and monkey. Vision Research 21, 1611–1615.CrossRefGoogle Scholar
Smith, V.C. & Pokorny, J. (1975). Spectral sensitivity of the cone photopigments between 400 and 500 nm. Vision Research 15, 161–165.CrossRefGoogle Scholar
Sperling, H.G. & Harwerth, R.S. (1971). Red-green cone interactions in the increment-threshold spectral sensitivity of primates. Science 172, 180–184.CrossRefGoogle ScholarPubMed
Sperling, H.G. & Mills, S.L. (1987). ERG and behavioral analysis of spectral sensitivity in normal and blue-blind rhesus monkeys. Colour Vision Deficiencies 8, 365–374.Google Scholar
Starr, M. (1975). The effects of various amino acids, dopamine, and some convulsants on the electroretinogram of the rabbit. Experimental Eye Research 21, 79–87.CrossRefGoogle ScholarPubMed
Stockton, R.A. & Slaughter, M.M. (1989). B-wave of the electroretinogram: a reflection of ON bipolar cell activity. Journal of General Physiology 93, 101–122.CrossRefGoogle ScholarPubMed
Tomita, T. & Yanagida, T. (1981). Origins of the ERG waves. Vision Research 21, 1703–1707.CrossRefGoogle ScholarPubMed
Valeton, J.M.& Van Norren, D. (1979). Transient tritanopia at the level of the ERG b−wave. Vision Research 19, 689–693.CrossRefGoogle ScholarPubMed
Van, Norren D. & Baron, W.S. (1977). Increment spectral sensitivities of the primate late receptor potential and b−wave. Vision Research 17, 807–810.Google Scholar
Wässle, H. & Chun, M.H. (1989). GABA-like immunoreactivity in the cat retina: light microscopy. Journal of Comparative Neurology 279, 43–54.CrossRefGoogle ScholarPubMed
Yazulla, S. (1986). GABAergic mechanisms in the retina. Progress in Retinal Research 5, 1–52.CrossRefGoogle Scholar
Zrenner, E. & Gouras, P. (1979). Blue-sensitive cones of the cat produce a rod-like electroretinogram. Investigations in Ophthalmology and Visual Science 18, 1076–1081.Google Scholar