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Glutathione peroxidases in poultry biology: Part 1. Classification and mechanisms of action

Published online by Cambridge University Press:  21 March 2018

P.F. SURAI ,
I.I. KOCHISH  and
V.I. FISININ
P.F. SURAI*
Affiliation:
Trakia University, Stara Zagora, Bulgaria Moscow State Academy of Veterinary Medicine and Biotechnologynamed after K.I. Skryabin, Moscow, Russia Szent Istvan University, Godollo, Hungary Sumy National Agrarian University, Sumy, Ukraine Odessa National Academy of Food Technologies, Ukraine
I.I. KOCHISH
Affiliation:
Moscow State Academy of Veterinary Medicine and Biotechnologynamed after K.I. Skryabin, Moscow, Russia
V.I. FISININ
Affiliation:
All Russian Institute of Poultry Husbandry, Sergiev Posad, Russia
*
Corresponding author: psurai@feedfood.co.uk
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Abstract

Glutathione peroxidase (GSH-Px) was described as a selenoprotein in 1973 and, since then, a great body of information has been accumulated to validate its important role in the antioxidant defence network in all animals, including poultry. The GSH-Px family includes at least eight members, and four of them (GSH-Px1, GSH-Px2, GSH-Px3 and GSH-Px4) are shown to be selenoproteins in animals. They are characterised by species- and tissue-specificity in their expression and activity. An optimal Se status in tissues/body is key for maximum expression of GSH-Px and therefore, in avian research GSH-Px activity is widely used as a biomarker for determining Se status and requirements. On the other hand, GSH-Px is an inducible enzyme and its activity depends on the level of stress and can be used as an index of antioxidant defences. In poultry production two forms of Se-dependent GSH-Px (GSH-Px1 and GSH-Px4) have received most attention. The aim of this paper is to review GSH-Px properties and functions in relation to poultry biology with special emphasis to its role in chicken adaptation to various stress conditions. Recent advances in selenoprotein identification and characterisation in relation to poultry Se status, dietary sources of Se and stress conditions can shed light on the roles of GSH-Px in avian biology.

Keywords

glutathione peroxidaseoxidative stresspoultryselenoproteins
Type
Review
Information
World's Poultry Science Journal , Volume 74 , Issue 2 , June 2018 , pp. 185 - 198
Copyright
Copyright © World's Poultry Science Association 2018 

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