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The role of propofol on mouse oocyte meiotic maturation and early embryo development

Published online by Cambridge University Press:  16 July 2018

Xia-Guang Duan ,
Zai-Qing Huang ,
Chun-Guang Hao ,
Xiao-Jun Zhi ,
Xiao-Bing Qi ,
Ling Ren ,
Sheng-Hui Luan  and
Cheng-Guang Liang
Xia-Guang Duan
Affiliation:
The Key Laboratory of National Education Ministry for Mammalian Reproductive Biology and Biotechnology, The Research Center for Laboratory Animal Science, College of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia, People’s Republic of China Department of Anesthesiology, The Third Affiliated Hospital of Inner Mongolia Medical University, Bao Gang Hospital, Baotou, Inner Mongolia, People’s Republic of China
Zai-Qing Huang
Affiliation:
Department of Anesthesiology, The Third Affiliated Hospital of Inner Mongolia Medical University, Bao Gang Hospital, Baotou, Inner Mongolia, People’s Republic of China
Chun-Guang Hao
Affiliation:
Department of Anesthesiology, The Third Affiliated Hospital of Inner Mongolia Medical University, Bao Gang Hospital, Baotou, Inner Mongolia, People’s Republic of China
Xiao-Jun Zhi
Affiliation:
Department of Anesthesiology, The Third Affiliated Hospital of Inner Mongolia Medical University, Bao Gang Hospital, Baotou, Inner Mongolia, People’s Republic of China
Xiao-Bing Qi
Affiliation:
Department of Anesthesiology, The Third Affiliated Hospital of Inner Mongolia Medical University, Bao Gang Hospital, Baotou, Inner Mongolia, People’s Republic of China
Ling Ren
Affiliation:
Department of Anesthesiology, The Third Affiliated Hospital of Inner Mongolia Medical University, Bao Gang Hospital, Baotou, Inner Mongolia, People’s Republic of China
Sheng-Hui Luan
Affiliation:
Department of Anesthesiology, The Third Affiliated Hospital of Inner Mongolia Medical University, Bao Gang Hospital, Baotou, Inner Mongolia, People’s Republic of China
Cheng-Guang Liang*
Affiliation:
The Key Laboratory of National Education Ministry for Mammalian Reproductive Biology and Biotechnology, The Research Center for Laboratory Animal Science, College of Life Science, Inner Mongolia University, No. 24 Zhao Jun Road, Hohhot, Inner Mongolia, People’s Republic of China
*
1All correspondence to: Cheng-Guang Liang, E-mail: alonlord@163.com
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Summary

Propofol is a intravenous anaesthetic most commonly used in ultrasound oocyte retrieval. We studied if the use of propofol had an effect on mouse oocyte maturation, pregnancy, childbirth and progeny and investigated the correlation between propofol side effects and reproductive performance in mice. There was no statistical difference in mating, pregnancy, childbirth, litter size, the number of stillbirths and survival between each group (P>0.05). Propofol also had no effect on polar body extrusion in oocyte maturation as well as on pronucleus formation and, subsequently, early embryo development (P>0.05). An increased concentration of propofol had no effect on this result, although propofol at more than 0.01 mg/ml reduced polar body extrusion. Different concentrations of propofol had no effect on oocyte culture in vitro, pronucleus formation and early embryo development.

Keywords

DeliveryEmbryo developmentLive birth ratesOocytePropofol
Type
Research Article
Information
Zygote , Volume 26 , Issue 4 , August 2018 , pp. 261 - 269
Copyright
© Cambridge University Press 2018 

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References

Alsalili, M., Thornton, S. & Fleming, S. (1997). The effect of the anaesthetic, Propofol, on in-vitro oocyte maturation, fertilization and cleavage in mice. Hum. Reprod. 12, 1271–1274.Google Scholar
Alves, H.C., Valentim, A.M., Olsson, I.A. & Antunes, L.M. (2007). Intraperitoneal propofol and propofol fentanyl, sufentanil and remifentanil combinations for mouse anaesthesia. Lab. Anim. 41, 329–336.Google Scholar
Ben-Shlomo, I., Moskovich, R., Katz, Y. & Shalev, E. (1999). Midazolam/ketamine sedative combination compared with fentanyl/propofol/isoflurane anaesthesia for oocyte retrieval. Hum. Reprod. 14, 1757–1759.Google Scholar
Christiaens, F., Janssenswillen, C., Verborgh, C., Moerman, I., Devroey, P., Van Steirteghem, A. & Camu, F. (1999). Propofol concentrations in follicular fluid during general anaesthesia for transvaginal oocyte retrieval. Hum. Reprod. 14, 345–348.Google Scholar
Coetsier, T., Dhont, M., De Sutter, P., Merchiers, E., Versichelen, L. & Rosseel, M.T. (1992). Propofol anaesthesia for ultrasound guided oocyte retrieval: accumulation of the anaesthetic agent in follicular fluid. Hum. Reprod. 7, 1422–1424.Google Scholar
Cong, L., Wang, Z., Li, J. & Li, S. (1999). Effect of zinc on the growth of cerebral cortex neurons of human fetus. J. Hyg. Res. 28, 281–282.Google Scholar
Gizzo, S., Noventa, M., Quaranta, M., Venturella, R., Vitagliano, A., Gangemi, M. & D’Antona, D. (2016). New frontiers in human assisted reproduction from research to clinical practice: several considerations. Mol. Med. Rep. 14, 4037–4041.Google Scholar
Han, Z., Liang, C.G., Cheng, Y., Duan, X., Zhong, Z., Potireddy, S., Moncada, C., Merali, S. & Latham, K.E. (2010). Oocyte spindle proteomics analysis leading to rescue of chromosome congression defects in cloned embryos. J. Proteome Res. 9, 6025–6032.Google Scholar
Jarahzadeh, M.H., Jouya, R., Mousavi, F.S., Dehghan-Tezerjani, M., Behdad, S. & Soltani, H.R. (2014). Propofol or thiopental sodium in patients undergoing reproductive assisted technologies: differences in hemodynamic recovery and outcome of oocyte retrieval: a randomized clinical trial. Iranian J. Reprod. Med. 12, 77–82.Google Scholar
Li, J., Xiong, M., Alhashem, H.M., Zhang, Y., Tilak, V., Patel, A., Siegel, A., Ye, J.H. & Bekker, A. (2014). Effects of prenatal propofol exposure on postnatal development in rats. Neurotoxicol. Teratol. 43, 51–58.Google Scholar
Ma, Y.Y., Shen, Y. & Zhang, L.S. (2008). Comparison of midazolam and propofol as conscious sedation in oocyte retrieval of IVE-ET. J. Zhejiang Univ. Med. Sci . 37, 304–307.Google Scholar
Mester, B., Ritter, L.J., Pitman, J.L., Bibby, A.H., Gilchrist, R.B., McNatty, K.P., Juengel, J.L. & McIntosh, C.J. (2015). Oocyte expression, secretion and somatic cell interaction of mouse bone morphogenetic protein 15 during the peri-ovulatory period. Reprod. Fertil. Dev . 27, 801–811.Google Scholar
Pina-Aguilar, R.E. (2008). Bringing together clinical embryology and basic reproduction around human cloning. Hum. Reprod. 23, 2875–2876.Google Scholar
Ratky, J., Brussow, K.P., Egerszegi, I., Torner, H., Schneider, F., Solti, L. & Manabe, N. (2005). Comparison of follicular and oocyte development and reproductive hormone secretion during the ovulatory period in Hungarian native breed, Mangalica, and Landrace gilts. J. Reprod. Dev. 51, 427–432.Google Scholar
Seyhan, A., Ata, B., Son, W.Y., Dahan, M.H. & Tan, S.L. (2014). Comparison of complication rates and pain scores after transvaginal ultrasound-guided oocyte pickup procedures for in vitro maturation and in vitro fertilization cycles. Fertil. Steril. 101, 705–709.Google Scholar
Siristatidis, C., Chrelias, C., Alexiou, A. & Kassanos, D. (2013). Clinical complications after transvaginal oocyte retrieval: a retrospective analysis. J. Obstet. Gynaecol. 33, 64–66.Google Scholar
Tanaka, Y. (1962). Histochemical change of the vaginal smear, epithelium and the endometrium of the mouse during the sex cycle. J. Japan. Obstet. Gynecol. Soc. 14, 273–282.Google Scholar
Thaete, L.G. & Malkinson, A.M. (1991). Cells of origin of primary pulmonary neoplasms in mice: morphologic and histochemical studies. Exp. Lung Res.. 17, 219–228.Google Scholar
Tomioka, S. & Nakajo, N. (2000). No genotoxic effect of propofol in chinese hamster ovary cells: analysis by sister chromatid exchanges. Acta Anaesthesiol. Scand. 44, 1261–1265.Google Scholar
Wang, Q., Racowsky, C. & Deng, M. (2011). Mechanism of the chromosome-induced polar body extrusion in mouse eggs. Cell Division. 6, 17.Google Scholar
Zhang, J., Wang, X. & Lu, R. (2013). Analgesic effect of acupuncture at hegu (LI 4) on transvaginal oocyte retrieval with ultrasonography. J. Trad. Chin. Med. 33, 294–297.Google Scholar