Neurobiology of Obesity

doi:10.1017/CBO9780511541643

Obesity is one of the prime contributors to ill health in modern society, affecting around 20–25% of the population. It can cause or exacerbate a variety of health problems and is often associated with several other diseases including type II diabetes, coronary heart disease and certain types of cancer. Significant progress has been made in understanding the role of the nervous system and, in particular, the complex interplay between a range of orexigenic and anorectic agents within specific hypothalamic nuclei in the regulation of energy balance, appetite and adiposity. Several different neuronal pathways, neurotransmitters and hormones have been identified as major players in the regulation of feeding behavior and body weight and these are now being targeted as having therapeutic potential. Written for academic researchers and graduate students, Neurobiology of Obesity is a concise overview of recent developments in this field, written by leading international experts.

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Contents

Frontmatter
pp i-iv
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Contents
pp v-vi
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Preface
pp vii-viii
- By Jenni Harvey, Department of pharmacology and Neuroscience, University of Dundee, J. Dominic Withers, Professor, Centre for Diabetes and Endocrinology, University College, London
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List of contributors
pp ix-xii
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1 - Introductory chapter
pp 1-19
- By Benjamin C. T. Field, Department of Metabolic Medicine, Division of Investigative Science, Imperial College, London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK, Caroline J. Small, Department of Metabolic Medicine, Division of Investigative Science, Imperial College, London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK, Stephen R. Bloom, Department of Metabolic Medicine, Division of Investigative Science, Imperial College, London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK
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2 - Genetics of human and rodent body weight regulation
pp 20-51
- By Karine Clément, Hôtel-Dieu Service de Nutrition Place du Parvis, Notre-Dame 75004, Paris, France
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3 - Hypothalamic control of energy homeostasis
pp 52-82
- By Neel S. Singhal, University of Pennsylvania, School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism Philadelphia, Pennsylvania 19104, USA, Rexford S. Ahima, University of Pennsylvania, School of Medicine, Department of Medicine, Division of Endocrinology, Diabetes and Metabolism Philadelphia, Pennsylvania 19104, USA
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4 - Leptin and insulin as adiposity signals
pp 83-126
- By Kevin D. Niswender, Diabetes, Endocrinology and Metabolism, 715, Preston Research Building, Vanderbilt University, Medical Center, 2220, Pierce Avenue Nashville, TN 37232–6303, USA
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5 - Convergence of leptin and insulin signaling networks in obesity
pp 127-163
- By Calum Sutherland, Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK, Mike Ashford, Division of Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY UK
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6 - Diet-induced obesity in animal models and what they tell us about human obesity
pp 164-195
- By Barry E. Levin, Neurology Service (127C) Veterans Affairs, Medical Center, 385, Tremont Avenue, East Orange, New Jersey 07018–1095, USA, Alison M. Strack, Neurology Service (127C) Veterans Affairs, Medical Center, 385, Tremont Avenue, East Orange, New Jersey 07018–1095, USA
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7 - Melanocortins and the control of body weight
pp 196-231
- By Virginie Tolle, MR. 549 INSERM-Université Paris, V, IFR Broca Ste-Anne, Paris, France, Malcolm J. Low, Center for the Study of Weight Regulation, Mail code L481, Oregon Health & Science University, 3181, SW Sam Jackson Park Road, Portland, OR 97239–3098, USA
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8 - Role of opiate peptides in regulating energy balance
pp 232-265
- By Richard J. Bodnar, Department of Psychology and Neuropsychology, Doctoral Sub-Program, Queens College, City Univeerdity of New York, USA, Allen S. Levine, Minnesota Obesity Centeer, Department of Food Science and Nutrition, University of Minnesota, USA
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9 - Ghrelin: an orexigenic signal from the stomach
pp 266-284
- By Tamas Horvath, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut 06520, USA
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10 - Central nervous system controls of adipose tissue apoptosis
pp 285-301
- By Mary Anne Della-Fera, University of Georgia, 444, Animal Science Complex, Athens, GA 30602–2771, USA, Mark W. Hamrick, Medical College of Georgia, Augusta, GA 30912–2000, USA, Clifton A. Baile, University of Georgia, 444, Animal Science Complex, Athens, GA 30602–2771, USA
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11 - Potential therapies to limit obesity
pp 302-319
- By Jason C. G. Halford, School of Psychology, Eleanor Rathbone Building, Bedford Street, South University of Liverpool, Liverpool, L69 7ZA, UK
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Index
pp 320-324
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Neurobiology of Obesity

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Contents

Frontmatter
pp i-iv

Contents
pp v-vi

Preface
pp vii-viii

List of contributors
pp ix-xii

1 - Introductory chapter
pp 1-19

2 - Genetics of human and rodent body weight regulation
pp 20-51

3 - Hypothalamic control of energy homeostasis
pp 52-82

4 - Leptin and insulin as adiposity signals
pp 83-126

5 - Convergence of leptin and insulin signaling networks in obesity
pp 127-163

6 - Diet-induced obesity in animal models and what they tell us about human obesity
pp 164-195

7 - Melanocortins and the control of body weight
pp 196-231

8 - Role of opiate peptides in regulating energy balance
pp 232-265

9 - Ghrelin: an orexigenic signal from the stomach
pp 266-284

10 - Central nervous system controls of adipose tissue apoptosis
pp 285-301

11 - Potential therapies to limit obesity
pp 302-319

Index
pp 320-324

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Neurobiology of Obesity

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