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The effects of stress–tension on depression and anxiety symptoms: evidence from a novel twin modelling analysis

Published online by Cambridge University Press:  08 September 2016

C. G. Davey ,
C. López-Solà ,
M. Bui ,
J. L. Hopper ,
C. Pantelis ,
L. F. Fontenelle  and
B. J. Harrison
C. G. Davey*
Affiliation:
Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Australia Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Australia
C. López-Solà
Affiliation:
Adult Mental Health Unit, Parc Taulí University Hospital, Sabadell, Spain CIBERSAM (Centro de Investigación en Red de Salud Mental), Carlos III Health Institute, Madrid, Spain
M. Bui
Affiliation:
Centre for Epidemiology and Biostatistics, Melbourne School of Population Health, The University of Melbourne, Melbourne, Australia
J. L. Hopper
Affiliation:
Centre for Epidemiology and Biostatistics, Melbourne School of Population Health, The University of Melbourne, Melbourne, Australia Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Irwon-ro 81, Gangnamgu, Seoul, South Korea
C. Pantelis
Affiliation:
Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Australia
L. F. Fontenelle
Affiliation:
Programa de Transtornos Obsessivo-Compulsivos e de Ansiedade, Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, Brazil Instituto de Saúde da Comunidade, Universidade Federal Fluminense (UFF), Rio de Janeiro, Brazil
B. J. Harrison
Affiliation:
Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne, Melbourne, Australia
*
*Address for correspondence: C. Davey, Orygen, The National Centre of Excellence in Youth Mental Health, 35 Poplar Road, Parkville, Victoria 3052, Australia. (Email: c.davey@unimelb.edu.au)
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Abstract

Background

Negative mood states are composed of symptoms of depression and anxiety, and by a third factor related to stress, tension and irritability. We sought to clarify the nature of the relationships between the factors by studying twin pairs.

Method

A total of 503 monozygotic twin pairs completed the Depression Anxiety Stress Scales (DASS), an instrument that assesses symptoms of depression, anxiety and stress–tension. We applied a recently developed twin regression methodology – Inference about Causation from Examination of FAmiliaL CONfounding (ICE FALCON) – to test for evidence consistent with the existence of ‘causal’ influences between the DASS factors.

Results

There was evidence consistent with the stress–tension factor having a causal influence on both the depression (p < 0.0001) and anxiety factors (p = 0.001), and for the depression factor having a causal influence on the anxiety factor (p < 0.001).

Conclusions

Our findings suggest a critical role for stress–tension in the structure of negative mood states, and that interventions that target it may be particularly effective in reducing depression and anxiety symptoms.

Keywords

Anxietydepressionstresstemperamenttwin studies
Type
Original Articles
Information
Psychological Medicine , Volume 46 , Issue 15 , November 2016 , pp. 3213 - 3218
Copyright
Copyright © Cambridge University Press 2016 

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References

Antony, MM, Bieling, PJ, Cox, BJ, Enns, MW, Swinson, RP (1998). Psychometric properties of the 42-item and 21-item versions of the Depression Anxiety Stress Scales in clinical groups and a community sample. Psychological Assessment 10, 176–181.CrossRefGoogle Scholar
Brown, TA, Campbell, LA, Lehman, CL, Grisham, JR, Mancill, RB (2001). Current and lifetime comorbidity of the DSM-IV anxiety and mood disorders in a large clinical sample. Journal of Abnormal Psychology 110, 585–599.CrossRefGoogle Scholar
Bui, M, Bjornerem, A, Ghasem-Zadeh, A, Dite, GS, Hopper, JL, Seeman, E (2013). Architecture of cortical bone determines in part its remodelling and structural decay. Bone 55, 353–358.CrossRefGoogle ScholarPubMed
Burton, KL, Williams, LM, Richard Clark, C, Harris, A, Schofield, PR, Gatt, JM (2015). Sex differences in the shared genetics of dimensions of self-reported depression and anxiety. Journal of Affective Disorders 188, 35–42.CrossRefGoogle ScholarPubMed
Clark, LA, Watson, D (1991). Tripartite model of anxiety and depression: psychometric evidence and taxonomic implications. Journal of Abnormal Psychology 100, 316–336.CrossRefGoogle ScholarPubMed
Crawford, JR, Henry, JD (2003). The Depression Anxiety Stress Scales (DASS): normative data and latent structure in a large non-clinical sample. British Journal of Clinical Psychology 42, 111–131.CrossRefGoogle Scholar
Henry, JD, Crawford, JR (2005). The short-form version of the Depression Anxiety Stress Scales (DASS-21): construct validity and normative data in a large non-clinical sample. British Journal of Clinical Psychology 44, 227–239.CrossRefGoogle Scholar
Hofmann, SG, Sawyer, AT, Witt, AA, Oh, D (2010). The effect of mindfulness-based therapy on anxiety and depression: a meta-analytic review. Journal of Consulting and Clinical Psychology 78, 169–183.CrossRefGoogle Scholar
Hopper, JL, Bui, QM, Erbas, B, Matheson, MC, Gurrin, LC, Burgess, JA, Lowe, AJ, Jenkins, MA, Abramson, MJ, Walters, EH, Giles, GG, Dharmage, SC (2012). Does eczema in infancy cause hay fever, asthma, or both in childhood? Insights from a novel regression model of sibling data. Journal of Allergy and Clinical Immunology 130, 1117–1122.e1.CrossRefGoogle ScholarPubMed
Hopper, JL, Foley, DL, White, PA, Pollaers, V (2013). Australian Twin Registry: 30 years of progress. Twin Research and Human Genetics 16, 34–42.CrossRefGoogle ScholarPubMed
Kovacs, M, Gatsonis, C, Paulauskas, SL, Richards, C (1989). Depressive disorders in childhood. IV. A longitudinal study of comorbidity with and risk for anxiety disorders. Archives of General Psychiatry 46, 776–782.Google Scholar
Lamers, F, Burstein, M, He, JP, Avenevoli, S, Angst, J, Merikangas, KR (2012). Structure of major depressive disorder in adolescents and adults in the US general population. British Journal of Psychiatry 201, 143–150.CrossRefGoogle ScholarPubMed
López-Solà, C, Fontenelle, LF, Alonso, P, Cuadras, D, Foley, DL, Pantelis, C, Pujol, J, Yücel, M, Cardoner, N, Soriano-Mas, C, Menchón, JM, Harrison, BJ (2014). Prevalence and heritability of obsessive–compulsive spectrum and anxiety disorder symptoms: a survey of the Australian Twin Registry. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 165B, 314–325.CrossRefGoogle ScholarPubMed
López-Solà, C, Fontenelle, LF, Bui, M, Hopper, JL, Pantelis, C, Yücel, M, Menchón, JM, Alonso, P, Harrison, BJ (2015). Aetiological overlap between obsessive–compulsive related and anxiety disorder symptoms: multivariate twin study. British Journal of Psychiatry 208, 26–33.CrossRefGoogle ScholarPubMed
Lovibond, PF (1998). Long-term stability of depression, anxiety, and stress syndromes. Journal of Abnormal Psychology 107, 520–526.CrossRefGoogle ScholarPubMed
Lovibond, PF, Lovibond, SH (1995 a). The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. Behaviour Research and Therapy 33, 335–343.CrossRefGoogle ScholarPubMed
Lovibond, SH, Lovibond, PF (1995 b). Manual for the Depression Anxiety Stress Scales. Psychology Foundation: Sydney.Google Scholar
Nutt, D (1997). Management of patients with depression associated with anxiety symptoms. Journal of Clinical Psychiatry 58 (Suppl. 8), 11–16.Google ScholarPubMed
Osman, A, Wong, JL, Bagge, CL, Freedenthal, S, Gutierrez, PM, Lozano, G (2012). The Depression Anxiety Stress Scales-21 (DASS-21): further examination of dimensions, scale reliability, and correlates. Journal of Clinical Psychology 68, 1322–1338.CrossRefGoogle ScholarPubMed
Schatzberg, AF, Cole, JO (1978). Benzodiazepines in depressive disorders. Archives of General Psychiatry 35, 1359–1365.CrossRefGoogle ScholarPubMed
Sharples, RW (1996). Stoics, Epicureans and Sceptics: An Introduction to Hellenistic Philosophy. Routledge: New York.Google Scholar
Sinclair, SJ, Siefert, CJ, Slavin-Mulford, JM, Stein, MB, Renna, M, Blais, MA (2012). Psychometric evaluation and normative data for the Depression, Anxiety, and Stress Scales-21 (DASS-21) in a nonclinical sample of U.S. adults. Evaluation and the Health Professions 35, 259–279.CrossRefGoogle Scholar
Stone, J, Dite, GS, Giles, GG, Cawson, J, English, DR, Hopper, JL (2012). Inference about causation from examination of familial confounding: application to longitudinal twin data on mammographic density measures that predict breast cancer risk. Cancer Epidemiology, Biomarkers and Prevention 21, 1149–1155.CrossRefGoogle ScholarPubMed
Szabó, M (2010). The short version of the Depression Anxiety Stress Scales (DASS-21): factor structure in a young adolescent sample. Journal of Adolescent Health 33, 1–8.CrossRefGoogle Scholar
Widiger, TA, Samuel, DB (2005). Diagnostic categories or dimensions? A question for the Diagnostic and Statistical Manual of Mental Disorders – fifth edition. Journal of Abnormal Psychology 114, 494–504.CrossRefGoogle ScholarPubMed
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