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Multimodality treatment in stage IV squamous cell carcinoma of the head and neck. A long-term follow-up

Published online by Cambridge University Press:  29 June 2007

A. Klima ,
I. Bergmann  and
S. Szepesi
A. Klima*
Affiliation:
Frankfurt, Germany
I. Bergmann
Affiliation:
Frankfurt, Germany
S. Szepesi
Affiliation:
Frankfurt, Germany
*
Dr A. Klima, HNO-Universitätsklinik Frankfurt, Th.Stern Kai 7, 6000 Frankfurt/Main, Germany.
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Abstract

We treated 114 patients with advanced inoperable head and neck cancer with a combined-modality protocol that included two cycles of chemotherapy followed by radiotherapy or three cycles of chemotherapy and in 18 patients with a radiosensitizing agent. At the beginning of the treatment all but one patient presented with a stage IV cancer. With a follow-up of 42–58 months, four patients are alive (three from the radiosensitizing group and one of the chemotherapy group). Complete response after the radiosensitizing agent correlated with superior prolonged disease-free survival in comparison to complete responses after chemotherapy at the level of p<0.009.

Keywords

Head and neck neoplasmsDrug therapy, combinationRadiotherapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 3 , March 1992 , pp. 234 - 237
Copyright
Copyright © JLO (1984) Limited 1992

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