Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-84b7d79bbc-rnpqb Total loading time: 0 Render date: 2024-07-25T13:13:42.688Z Has data issue: false hasContentIssue false

7 - Biocolloid Rheology

Published online by Cambridge University Press:  07 April 2021

By
Surita Bhatia  and
Wendy Hom
Edited by
Norman J. Wagner  and
Jan Mewis
Norman J. Wagner
Affiliation:
University of Delaware
Jan Mewis
Affiliation:
KU Leuven, Belgium
Get access

Summary

This chapter applies the fundamental framework for colloidal forces and rheology to biocolloids. We define biocolloids broadly as colloidal assemblies with primary applications that are biomedical in nature, e.g., (i) block copolymers used in pharmaceutical formulations and biomaterials applications, and (ii) biomacromolecules that can be reasonably described with colloidal descriptions for the interparticle interactions; namely globular proteins and protein assemblies such as casein micelles. Our discussion mainly focuses on systems where concepts from colloidal interactions prove useful in interpreting the rheological behavior. The chapter briefly discusses the importance of colloidal rheology to applications in drug delivery, biomolecular therapeutics, and foods. Examples from both classic publications and recent literature are provided, along with models to describe the rheological behavior. Specific systems discussed include thermoresponsive micellar block copolymers, associative polymers, biomimetic block copolymer assemblies with stereocomplexes and crystalline domains as well as globular proteins.

Keywords

rheologybiocolloidssuspensionsreviewproteinsmicelles
Type
Chapter
Information
Theory and Applications of Colloidal Suspension Rheology , pp. 291 - 315
Publisher: Cambridge University Press
Print publication year: 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Malmsten, M, Lindman, B. Self-assembly in aqueous block copolymer solutions. Macromolecules. 1992;25(20):5440–5445.Google Scholar
Yu, G-E, Deng, Y, Dalton, S, Wang, Q-G, Attwood, D, Price, C, et al. Micellisation and gelation of triblock copoly (oxyethylene/oxypropylene/oxyethylene), F127. Journal of the Chemical Society, Faraday Transactions. 1992;88(17):2537–2544.CrossRefGoogle Scholar
Wanka, G, Hoffmann, H, Ulbricht, W. Phase diagrams and aggregation behavior of poly (oxyethylene)-poly (oxypropylene)-poly (oxyethylene) triblock copolymers in aqueous solutions. Macromolecules. 1994;27(15):4145–4159.CrossRefGoogle Scholar
Alexandridis, P, Holzwarth, JF, Hatton, TA. Micellization of poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) triblock copolymers in aqueous solutions: Thermodynamics of copolymer association. Macromolecules. 1994;27(9):2414–2425.Google Scholar
Mortensen, K, Brown, W, Joergensen, E. Phase behavior of poly (propylene oxide)-poly (ethylene oxide)-poly (propylene oxide) triblock copolymer melt and aqueous solutions. Macromolecules. 1994;27(20):5654–5666.Google Scholar
Prud'homme, RK, Wu, G, Schneider, DK. Structure and rheology studies of poly (oxyethylene−oxypropylene−oxyethylene) aqueous solution. Langmuir. 1996;12(20):4651–4659.Google Scholar
Anderson, BC, Pandit, NK, Mallapragada, SK. Understanding drug release from poly (ethylene oxide)-b-poly (propylene oxide)-b-poly (ethylene oxide) gels. Journal of Controlled Release. 2001;70(1):157–167.CrossRefGoogle ScholarPubMed
Arevalo-Silva, CA, Eavey, RD, Cao, Y, Vacanti, M, Weng, Y, Vacanti, CA. Internal support of tissue-engineered cartilage. Archives of Otolaryngology – Head and Neck Surgery. 2000;126(12):1448–1452.Google Scholar
Cao, YL, Rodriguez, A, Vacanti, M, Ibarra, C, Arevalo, C, Vacanti, CA. Comparitive study of the use of poly(glycolic acid), calcium alginate and pluronics in the engineering of autologous porcine cartilage. Journal of Biomaterials Science – Polymer Edition. 1998;9(5):475–487.Google Scholar
Matthew, J, Bhatia, S, Roberts, S. Pluronic F127 gels as materials for mammalian cell encapsulation. Polymer Preprints. 2002;43(2):769–770.Google Scholar
Matthew, J, Nazario, Y, Roberts, S, Bhatia, S. Effect of mammalian cell culture medium on the gelation properties of Pluronic F127. Biomaterials. 2002;23(23):4615–4619.CrossRefGoogle ScholarPubMed
Khattak, SF, Bhatia, SR, Roberts, SC. Pluronic® F127 as a cell encapsulation material: Utilization of membrane stabilizing agents. Tissue Engineering. 2005;11(5–6):974–983.Google Scholar
Bogue, RH. The viscosity of gelatin sols. Journal of the American Chemical Society. 1921;43(8):1764–1773.Google Scholar
de Kruif, C. Chapter VI caseins. In Aalbersberg, WY, Hamer, RJ, Jasperse, P, de Jongh, HHJ, de Kruif, CG, Walstra, P, de Wolf, FA (eds.) Progress in Biotechnology, vol. 23. Amsterdam: Elsevier; 2003. pp. 219–269.Google Scholar
de Kruif, C, Jeurnink, TJ, Zoon, P. The viscosity of milk during the initial stages of renneting. Netherlands Milk and Dairy Journal (Netherlands). 1992;46(2):123–137.Google Scholar
Walstra, P, Geurts, TJ, Walstra, P, Wouters, JT. Dairy Science and Technology. Boca Raton, FL: CRC press; 2005.CrossRefGoogle Scholar
de Kruif, CG, Jeurnink, TJM, Zoon, P. The viscosity of milk during the initial-stages of renneting. Netherlands Milk and Dairy Journal. 1992;46(2):123–137.Google Scholar
Bremer, LGB, Bijsterbosch, BH, Schrijvers, R, Vanvliet, T, Walstra, P. On the fractal nature of the structure of acid casein gels. Colloids and Surfaces. 1990;51:159–170.Google Scholar
Dickinson, E, Bergenstahl, B. Food Colloids: Proteins, Lipids and Polysaccharides. Cambridge: Woodhead Publishing Limited; 1997.Google Scholar
van Marle, ME, van den Ende, D, de Kruif, CG, Mellema, J. Steady-shear viscosity of stirred yogurts with varying ropiness. Journal of Rheology. 1999;43(6):1643–1662.Google Scholar
Potanin, AA, Derooij, R, Vandenende, D, Mellema, J. Microrheological modeling of weakly aggregated dispersions. Journal of Chemical Physics. 1995;102(14):5845–5853.Google Scholar
Buscall, R, McGowan, JI, Mortonjones, AJ. The rheology of concentrated dispersions of weakly attracting colloidal particles with and without wall slip. Journal of Rheology. 1993;37(4):621–641.Google Scholar
Goodwin, JW, Hughes, RW, Partridge, SJ, Zukoski, CF. The elasticity of weakly flocculated suspensions Journal of Chemical Physics. 1986;85(1):559–566.Google Scholar
Olivares, ML, Berli, CLA, Zorrilla, S. Connection between dynamic rheometry and pair interactions of casein micelles in concentrated skim milk. Food Hydrocolloids. 2018;74:104–107.CrossRefGoogle Scholar
Buscall, R. Effect of long-range repulsive forces on the viscosity of concentrated latices: Comparison of experimental data with an effective hard-sphere model. Journal of the Chemical Society, Faraday Transactions. 1991;87(9):1365–1370.Google Scholar
Nöbel, S, Weidendorfer, K, Hinrichs, J. Apparent voluminosity of casein micelles determined by rheometry. Journal of Colloid and Interface Science. 2012;386(1):174–180.CrossRefGoogle ScholarPubMed
Tuinier, R, De Kruif, C. Stability of casein micelles in milk. The Journal of Chemical Physics. 2002;117(3):1290–1295.Google Scholar
Berli, CL, Quemada, D. Rheological modeling of microgel suspensions involving solid–liquid transition. Langmuir. 2000;16(21):7968–7974.Google Scholar
Mewis, J, Wagner, NJ. Colloidal Suspension Rheology. Cambridge: Cambridge University Press; 2012. 393 p.Google Scholar
Bouchoux, A, Debbou, B, Gesan-Guiziou, G, Famelart, MH, Doublier, JL, Cabane, B. Rheology and phase behavior of dense casein micelle dispersions. Journal of Chemical Physics. 2009;131(16):165106.Google Scholar
Zhang, Z, Liu, Y. Recent progresses of understanding the viscosity of concentrated protein solutions. Current Opinion in Chemical Engineering. 2017;16:48–55.Google Scholar
Anderson, BC, Cox, SM, Bloom, PD, Sheares, VV, Mallapragada, SK. Synthesis and characterization of diblock and gel-forming pentablock copolymers of tertiary amine methacrylates, poly (ethylene glycol), and poly (propylene glycol). Macromolecules. 2003;36(5):1670–1676.CrossRefGoogle Scholar
Determan, MD, Guo, L, Lo, C-T, Thiyagarajan, P, Mallapragada, SK. pH-and temperature-dependent phase behavior of a PEO-PPO-PEO-based pentablock copolymer in aqueous media. Physical Review E. 2008;78(2):021802.Google Scholar
Cohn, D, Lando, G, Sosnik, A, Garty, S, Levi, A. PEO–PPO–PEO-based poly (ether ester urethane) as degradable reverse thermo-responsive multiblock copolymers. Biomaterials. 2006;27(9):1718–1727.CrossRefGoogle ScholarPubMed
Jiang, J, Malal, R, Li, C, Lin, MY, Colby, RH, Gersappe, D, et al. Rheology of thermoreversible hydrogels from multiblock associating copolymers. Macromolecules. 2008;41(10):3646–3652.Google Scholar
Alexandridis, P, Olsson, U, Lindman, B. Structural polymorphism of amphiphilic copolymers: Six lyotropic liquid crystalline and two solution phases in a poly (oxybutylene)-b-poly (oxyethylene)–water–xylene system. Langmuir. 1997;13(1):23–34.Google Scholar
Hamley, I. Amphiphilic diblock copolymer gels: The relationship between structure and rheology. Philosophical Transactions of the Royal Society of London A: Mathematical, Physical and Engineering Sciences. 2001;359(1782):1017–1044.Google Scholar
Hamley, IW, Daniel, C, Mingvanish, W, Mai, S-M, Booth, C, Messe, L, et al. From hard spheres to soft spheres: The effect of copolymer composition on the structure of micellar cubic phases formed by diblock copolymers in aqueous solution. Langmuir. 2000;16(6):2508–2514.Google Scholar
Hamley, I, Mortensen, K, Yu, G-E, Booth, C. Mesoscopic crystallography: A small-angle neutron scattering study of the body-centered cubic micellar structure formed in a block copolymer gel. Macromolecules. 1998;31(20):6958–6963.Google Scholar
Pople, J, Hamley, I, Fairclough, J, Ryan, A, Komanschek, B, Gleeson, A, et al. Ordered phases in aqueous solutions of diblock oxyethylene/oxybutylene copolymers investigated by simultaneous small-angle X-ray scattering and rheology. Macromolecules. 1997;30(19):5721–5728.CrossRefGoogle Scholar
Hamley, I, Pople, J, Diat, O. A thermally induced transition from a body-centred to a face-centred cubic lattice in a diblock copolymer gel. Colloid & Polymer Science. 1998;276(5):446–450.Google Scholar
Quah, SP, Smith, AJ, Preston, AN, Laughlin, ST, Bhatia, SR. Large-area alginate/PEO-PPO-PEO hydrogels with thermoreversible rheology at physiological temperatures. Polymer. 2018;135:171–177.CrossRefGoogle Scholar
Jalaal, M, Cottrell, G, Balmforth, N, Stoeber, B. On the rheology of pluronic F127 aqueous solutions. Journal of Rheology. 2017;61(1):139–146.CrossRefGoogle Scholar
Chen, S-H, Chen, WR, Mallamace, F. The glass-to-glass transition and its end point in a copolymer micellar system. Science. 2003;300(5619):619–622.CrossRefGoogle Scholar
Kelarakis, A, Mingvanish, W, Daniel, C, Li, H, Havredaki, V, Booth, C, et al. Rheology and structures of aqueous gels of diblock (oxyethylene–oxybutylene) copolymers with lengthy oxyethylene blocks. Physical Chemistry Chemical Physics. 2000;2(12):2755–2763.CrossRefGoogle Scholar
Sharma, PK, Bhatia, SR. Effect of anti-inflammatories on pluronic (R) F127: micellar assembly, gelation and partitioning. International Journal of Pharmaceutics. 2004;278(2):361–377.Google Scholar
Sharma, PK, Reilly, MJ., Bhatia, SK, Sakhitab, N, Archambault, JD, Bhatia, SR. Effect of pharmaceuticals on thermoreversible gelation of PEO-PPO-PEO copolymers. Colloids and Surfaces B–Biointerfaces. 2008;63(2):229–235.Google Scholar
Sharma, PK, Reilly, MJ, Jones, DN, Robinson, PM, Bhatia, SR. The effect of pharmaceuticals on the nanoscale structure of PEO-PPO-PEO micelles. Colloids and Surfaces B–Biointerfaces. 2008;61(1):53–60.Google Scholar
Sharma, PK, Matthew, JE, Bhatia, SR. Structure and assembly of PEO-PPO-PEO co-polymers in mammalian cell-culture media. Journal of Biomaterials Science–Polymer Edition. 2005;16(9):1139–1151.CrossRefGoogle ScholarPubMed
Lee, Y, Chung, HJ, Yeo, S, Ahn, C-H, Lee, H, Messersmith, PB, et al. Thermo-sensitive, injectable, and tissue adhesive sol–gel transition hyaluronic acid/pluronic composite hydrogels prepared from bio-inspired catechol-thiol reaction. Soft Matter. 2010;6(5):977–983.CrossRefGoogle Scholar
Chen, CC, Fang, CL, Al-Suwayeh, SA, Leu, YL, Fang, JY. Transdermal delivery of selegiline from alginate-Pluronic composite thermogels. International Journal of Pharmaceutics. 2011;415(1–2):119–128.Google Scholar
Stoppel, WL, White, JC, Horava, SD, Bhatia, SR, Roberts, SC. Transport of biological molecules in surfactant-alginate composite hydrogels. Acta Biomaterialia. 2011(7):3988–3998.CrossRefGoogle ScholarPubMed
White, JC, Saffer, EM, Bhatia, SR. Alginate/PEO-PPO-PEO composite hydrogels with thermally-active plasticity. Biomacromolecules. 2013;14(12):4456–4464.Google Scholar
Li, H, Yu, G-E, Price, C, Booth, C, Hecht, E, Hoffmann, H. Concentrated aqueous micellar solutions of diblock copoly (oxyethylene/oxybutylene) E41B8: A study of phase behavior. Macromolecules. 1997;30(5):1347–1354.Google Scholar
Hyun, K, Nam, JG, Wilhellm, M, Ahn, KH, Lee, SJ. Large amplitude oscillatory shear behavior of PEO-PPO-PEO triblock copolymer solutions. Rheologica Acta. 2006;45(3):239–249.CrossRefGoogle Scholar
Green, M, Tobolsky, A. A new approach to the theory of relaxing polymeric media. The Journal of Chemical Physics. 1946;14(2):80–92.CrossRefGoogle Scholar
Annable, T, Buscall, R, Ettelaie, R, Whittlestone, D. The rheology of solutions of associating polymers: Comparison of experimental behavior with transient network theory. Journal of Rheology. 1993;37(4):695–726.CrossRefGoogle Scholar
Tanaka, F, Edwards, S. Viscoelastic properties of physically crosslinked networks. 1. Transient network theory. Macromolecules. 1992;25(5):1516–1523.Google Scholar
Nguyen-Misra, M, Misra, S, Mattice, WL. Bridging by end-adsorbed triblock copolymers. Macromolecules. 1996;29(5):1407–1415.Google Scholar
Tae, G, Kornfield, JA, Hubbell, JA, Lal, J. Ordering transitions of fluoroalkyl-ended poly (ethylene glycol): Rheology and SANS. Macromolecules. 2002;35(11):4448–4457.Google Scholar
Semenov, A, Joanny, J-F, Khokhlov, A. Associating polymers: Equilibrium and linear viscoelasticity. Macromolecules. 1995;28(4):1066–1075.Google Scholar
Deming, TJ. Polypeptide hydrogels via a unique assembly mechanism. Soft Matter. 2005;1(1):28–35.Google Scholar
Carlsen, A, Lecommandoux, S. Self-assembly of polypeptide-based block copolymer amphiphiles. Current Opinion in Colloid & Interface Science. 2009;14(5):329–339.Google Scholar
Tew, GN, Sanabria-DeLong, N, Agrawal, SK, Bhatia, SR. New properties from PLA-PEO-PLA hydrogels. Soft Matter. 2005;1(4):253–258.CrossRefGoogle ScholarPubMed
Agrawal, SK, Sanabria-DeLong, N, Coburn, JM, Tew, GN, Bhatia, SR. Novel drug release profiles from micellar solutions of PLA-PEO-PLA triblock copolymers. Journal of Controlled Release. 2006;112(1):64–71.Google Scholar
Agrawal, SK, Sanabria-DeLong, N, Jemian, PR, Tew, GN, Bhatia, SR. Micro- to nanoscale structure of biocompatible PLA-PEO-PLA hydrogels. Langmuir. 2007;23(9):5039–5044.CrossRefGoogle ScholarPubMed
Sanabria-DeLong, N, Agrawal, SK, Bhatia, SR, Tew, GN. Controlling hydrogel properties by crystallization of hydrophobic domains. Macromolecules. 2006;39(4):1308–1310.Google Scholar
Metters, AT, Anseth, KS, Bowman, CN. A statistical kinetic model for the bulk degradation of PLA-b-PEG-b-PLA hydrogel networks: Incorporating network non-idealities. Journal of Physical Chemistry B. 2001;105(34):8069–8076.Google Scholar
Anseth, KS, Metters, AT, Bryant, SJ, Martens, PJ, Elisseeff, JH, Bowman, CN. In situ forming degradable networks and their application in tissue engineering and drug delivery. Journal of Controlled Release. 2002;78(1–3):199–209.Google Scholar
Garric, X, Garreau, H, Vert, M, Moles, JP. Behaviors of keratinocytes and fibroblasts on films of PLA(50)-PEO-PLA(50) triblock copolymers with various PLA segment lengths. Journal of Materials Science: Materials in Medicine. 2008;19(4):1645–1651.Google Scholar
Molina, I, Li, SM, Martinez, MB, Vert, M. Protein release from physically crosslinked hydrogels of the PLA/PEO/PLA triblock copolymer-type. Biomaterials. 2001;22(4):363–369.Google Scholar
Lee, HT, Lee, DS. Thermoresponsive phase transitions of PLA-block-PEO-block-PLA triblock stereo-copolymers in aqueous solution. Macromolecular Research. 2002;10(6):359–364.Google Scholar
Li, SM, Rashkov, I, Espartero, JL, Manolova, N, Vert, M. Synthesis, characterization, and hydrolytic degradation of PLA/PEO/PLA triblock copolymers with long poly(L-lactic acid) blocks. Macromolecules. 1996;29(1):57–62.CrossRefGoogle Scholar
Li, F, Li, SM, Vert, M. Synthesis and rheological properties of polylactide/poly(ethylene glycol) multiblock copolymers. Macromolecular Bioscience. 2005;5(11):1125–1131.CrossRefGoogle ScholarPubMed
Jing, Y, Quan, C, Liu, B, Jiang, Q, Zhang, C. A mini review on the functional biomaterials based on poly (lactic acid) stereocomplex. Polymer Reviews. 2016;56(2):262–286.Google Scholar
Fujiwara, T, Mukose, T, Yamaoka, T, Yamane, H, Sakurai, S, Kimura, Y. Novel thermo‐responsive formation of a hydrogel by stereo‐complexation between PLLA‐PEG‐PLLA and PDLA‐PEG‐PDLA block copolymers. Macromolecular Bioscience. 2001;1(5):204–208.3.0.CO;2-H>CrossRefGoogle Scholar
Agrawal, SK, Sanabria-DeLong, N, Tew, GN, Bhatia, SR. Rheological characterization of biocompatible associative polymer hydrogels with crystalline and amorphous endblocks. Journal of Materials Research. 2006;21(8):2118–2125.Google Scholar
Agrawal, SK, Sanabria-DeLong, N, Tew, GN, Bhatia, SR. Structural characterization of PLA-PEO-PLA solutions and hydrogels: Crystalline vs amorphous PLA domains. Macromolecules. 2008;41(5):1774–1784.Google Scholar
Semenov, A, Nyrkova, I, Khokhlov, A. Polymers with strongly interacting groups: Theory for nonspherical multiplets. Macromolecules. 1995;28(22):7491–7500.CrossRefGoogle Scholar
Aamer, KA, Sardinha, H, Bhatia, SR, Tew, GN. Rheological studies of PLLA-PEO-PLLA triblock copolymer hydrogels. Biomaterials. 2004;25(6):1087–1093.Google Scholar
Yin, X, Hewitt, DR, Quah, SP, Zheng, B, Mattei, GS, Khalifah, PG, et al. Impact of stereochemistry on rheology and nanostructure of PLA–PEO–PLA triblocks: Stiff gels at intermediate l/d-lactide ratios. Soft Matter. 2018;14(35):7255–7263.Google Scholar
Jezek, J, Rides, M, Derham, B, Moore, J, Cerasoli, E, Simler, R., et al. Viscosity of concentrated therapeutic protein compositions. Advanced Drug Delivery Reviews. 2011;63(13):1107–1117.Google Scholar
Perez-Ramirez, B, Guziewicz, N, Simler, R. Preformulation research: Assessing protein solution behavior during early development. In Jameel, F, Hershenson, S (eds.) Formulation and Process Development Strategies for Manufacturing Biopharmaceuticals. Hoboken: Wiley; 2010; pp. 119–146.Google Scholar
Andreeva, A, Howorth, D, Chothia, C, Kulesha, E, Murzin, AG. SCOP2 prototype: A new approach to protein structure mining. Nucleic Acids Research. 2013;42(D1):D310–D314.Google Scholar
Sharma, V, Jaishankar, A, Wang, Y-C, McKinley, GH. Rheology of globular proteins: Apparent yield stress, high shear rate viscosity and interfacial viscoelasticity of bovine serum albumin solutions. Soft Matter. 2011;7(11):5150–5160.Google Scholar
Ikeda, S, Nishinari, K. On solid-like rheological behaviors of globular protein solutions. Food Hydrocolloids. 2001;15(4–6):401–406.Google Scholar
Cardinaux, F, Zaccarelli, E, Stradner, A, Bucciarelli, S, Farago, B, Egelhaaf, SU, et al. Cluster-driven dynamical arrest in concentrated lysozyme solutions. The Journal of Physical Chemistry B. 2011;115(22):7227–7237.CrossRefGoogle ScholarPubMed
Liu, Y, Porcar, L, Chen, J, Chen, W-R, Falus, P, Faraone, A, et al. Lysozyme protein solution with an intermediate range order structure. The Journal of Physical Chemistry B. 2010;115(22):7238–7247.Google Scholar
Ikeda, S, Nishinari, K. Intermolecular forces in bovine serum albumin solutions exhibiting solidlike mechanical behaviors. Biomacromolecules. 2000;1(4):757–763.Google Scholar
Castellanos, MM, Pathak, JA, Colby, RH. Both protein adsorption and aggregation contribute to shear yielding and viscosity increase in protein solutions. Soft Matter. 2014;10(1):122–131.Google Scholar
Tein, YS, Zhang, Z, Wagner, NJ. Competitive surface activity of monoclonal antibodies and nonionic surfactants at the air–water interface determined by interfacial rheology and neutron reflectometry. Langmuir. 2020;36(27):7814–7823.Google Scholar
Russel, WB, Saville, DA, Schowalter, WR. Colloidal Dispersions. Cambridge: Cambridge University Press; 1991.Google Scholar
Foffi, G, Savin, G, Bucciarelli, S, Dorsaz, N, Thurston, GM, Stradner, A, et al. Hard sphere-like glass transition in eye lens α-crystallin solutions. Proceedings of the National Academy of Sciences. 2014;111(47):16748–16753.Google Scholar
Heinen, M, Zanini, F, Roosen-Runge, F, Fedunová, D, Zhang, F, Hennig, M, et al. Viscosity and diffusion: Crowding and salt effects in protein solutions. Soft Matter. 2012;8(5):1404–1419.Google Scholar
Castellanos, MM, Clark, NJ, Watson, MC, Krueger, S, McAuley, A, Curtis, JE. Role of molecular flexibility and colloidal descriptions of proteins in crowded environments from small-angle scattering. The Journal of Physical Chemistry B. 2016;120(49):12511–12518.Google Scholar
Sarangapani, PS, Hudson, SD, Jones, RL, Douglas, JF, Pathak, JA. Critical examination of the colloidal particle model of globular proteins. Biophysical journal. 2015;108(3):724–737.Google Scholar
Ross, PD, Minton, AP. Hard quasi-spherical model for viscosity of hemoglobin solutions. Biochemical and Biophysical Research Communications. 1977;76(4):971–976.Google Scholar
Lilyestrom, WG, Yadav, S, Shire, SJ, Scherer, TM. Monoclonal antibody self-association, cluster formation, and rheology at high concentrations. The Journal of Physical Chemistry B. 2013;117(21):6373–6384.Google Scholar
Godfrin, PD, Hudson, SD, Hong, K, Porcar, L, Falus, P, Wagner, NJ, et al. Short-time glassy dynamics in viscous protein solutions with competing interactions. Physical Review Letters. 2015;115(22):228302.Google Scholar
Shire, SJ, Shahrokh, Z, Liu, J. Challenges in the development of high protein concentration formulations. Journal of Pharmaceutical Sciences. 2004;93(6):1390–1402.Google Scholar
Rader, RA. Biopharmaceutical Products in the US and European Markets. Rockville, MD: BioPlan Associates, Incorporated; 2007.Google Scholar
Liu, J, Nguyen, MD, Andya, JD, Shire, SJ. Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution. Journal of Pharmaceutical Sciences. 2005;94(9):1928–1940.Google Scholar
Saluja, A, Badkar, AV, Zeng, DL, Kalonia, DS. Ultrasonic rheology of a monoclonal antibody (IgG2) solution: Implications for physical stability of proteins in high concentration formulations. Journal of Pharmaceutical Sciences. 2007;96(12):3181–3195.CrossRefGoogle ScholarPubMed
Saluja, A, Badkar, AV, Zeng, DL, Nema, S, Kalonia, DS. Application of high-frequency rheology measurements for analyzing protein–protein interactions in high protein concentration solutions using a model monoclonal antibody (IgG(2)). Journal of Pharmaceutical Sciences. 2006;95(9):1967–1983.CrossRefGoogle Scholar
Godfrin, PD, Zarraga, IE, Zarzar, J, Porcar, L, Falus, P, Wagner, NJ, et al. Effect of hierarchical cluster formation on the viscosity of concentrated monoclonal antibody formulations studied by neutron scattering. The Journal of Physical Chemistry B. 2016;120(2):278–291.Google Scholar
Saluja, A, Kalonia, DS. Nature and consequences of protein–protein interactions in high protein concentration solutions. International Journal of Pharmaceutics. 2008;358(1–2):1–15.CrossRefGoogle ScholarPubMed
Patel, AR, Kerwin, BA, Kanapuram, SR. Viscoelastic characterization of high concentration antibody formulations using quartz crystal microbalance with dissipation monitoring. Journal of Pharmaceutical Sciences. 2009;98(9):3108–3116.Google Scholar
Yearley, EJ, Godfrin, PD, Perevozchikova, T, Zhang, H, Falus, P, Porcar, L, et al. Observation of small cluster formation in concentrated monoclonal antibody solutions and its implications to solution viscosity. Biophysical Journal. 2014;106(8):1763–1770.Google Scholar
Yearley, EJ, Zarraga, IE, Shire, SJ, Scherer, TM, Gokarn, Y, Wagner, NJ, et al. Small-angle neutron scattering characterization of monoclonal antibody conformations and interactions at high concentrations. Biophysical Journal. 2013;105(3):720–731.Google Scholar
Dear, BJ, Hung, JJ, Truskett, TM, Johnston, KP. Contrasting the influence of cationic amino acids on the viscosity and stability of a highly concentrated monoclonal antibody. Pharmaceutical Research. 2017;34(1):193–207.CrossRefGoogle ScholarPubMed
Weiss, RM, Short, AL, Meyer, TY. Sequence-controlled copolymers prepared via entropy-driven ring-opening metathesis polymerization. ACS Macro Letters. 2015;4(9):1039–1043.Google Scholar
Weiss, RM, Li, J, Liu, HH, Washington, MA, Giesen, JA, Grayson, SM, et al. Determining sequence fidelity in repeating sequence poly(lactic-co-glycolic acid)s. Macromolecules. 2017;50(2):550–560.Google Scholar
Washington, MA, Swiner, DJ, Bell, KR, Fedorchak, MV, Little, SR, Meyer, TY. The impact of monomer sequence and stereochemistry on the swelling and erosion of biodegradable poly(lactic-co-glycolic acid) matrices. Biomaterials. 2017;117:66–76.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×