Endocrine disrupters or endocrine disrupting chemicals (ECDs) were recognised by the Beyond 2020 Strategy as an “emerging policy issue”. The annual costs to human health and the environment from the use of EDCs are estimated to be in the hundreds of billions of Euros in the EU alone. There is hence an acute need to reduce and prevent these risks in line with the high levels of human health and environmental protection that the EU is pursuing. The EU represents the only legal system where EDCs are explicitly addressed in laws underpinned by the precautionary principle, i.e., the REACH Regulation, the Biocidal Products Regulation (BPR), and the Plant Protection Products Regulation (PPPR). However, as this chapter demonstrates, significant delays, not to mention gridlock in the regulatory plan, are being caused by the very complexity of endocrine disruptive risks, numerous legal loopholes, friction between the huge economic interests involved in the EDCs marked, and finally the need to reduce their production and use for reasons of human and environmental health. Basing the analysis on the recent legislative struggle over how EDCs should be defined, this chapter argues for of the incorporation of a precautionary stance as early the risk assessment phase.