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8 - Assessing Outcomes in Schizophrenia in Later Life

from Section 3 - Outcome and Course

Published online by Cambridge University Press:  15 March 2019

Carl I. Cohen
Affiliation:
SUNY Downstate Medical Center
Paul D. Meesters
Affiliation:
Friesland Mental Health Services
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Summary

Outcome is an unsettled area of debate in psychiatry that has varied historically and across investigative sites. It has included symptoms as well as social indices. This chapter examines various outcome dimensions in older adults with schizophrenia (OAS) as well as the associations between them and various predictor variables. Based on cross-sectional and longitudinal data from a community sample of OAS living in New York City, contrary to earlier views of a quiescent end stage in later life, heterogeneity in course persists into later life. Because of the fluidity of outcome and the various combinations of favorable outcomes, “recovering” remains a viable conceptual framework in later life. Although the outcome indices are largely independent of each other, provisional data suggest that, over time, alleviation of depressive symptoms is associated with improved community integration, which in turn is associated with higher rates of remission; improved cognitive function may also augment remission. There were few other predictors of the various outcome indices suggesting that clinical strategies need to target the specific clinical or social domain. Because of the various combinations of outcome and the high independence among outcome dimensions, an individualized care approach can achieve the optimal outcome.
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Schizophrenia and Psychoses in Later Life
New Perspectives on Treatment, Research, and Policy
, pp. 95 - 111
Publisher: Cambridge University Press
Print publication year: 2019

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References

Wing, J., Long-term outcome in schizophrenia, Schizophrenia Bulletin, 14, 669–73, 1988.CrossRefGoogle ScholarPubMed
Hegarty, J.D., Baldessarini, R.J., Tohen, M., et al., One-hundred years of schizophrenia: a meta-analysis of the outcome literature, American Journal of Psychiatry, 151, 1409–16, 1994.Google ScholarPubMed
Cohen, C., Poverty and the course of schizophrenia: Implications for research and policy, Hospital and Community Psychiatry, 22, 951–8, 1993.Google Scholar
McGlashan, T., A selective review of recent North American long-term followup studies of schizophrenia, Schizophrenia Bulletin, 14, 515–42, 1988.Google ScholarPubMed
Jääskeläinen, E., Paulina, J., Hirvonen, N., et al., A systematic review and meta-analysis of recovery in schizophrenia, Schizophrenia Bulletin, 39, 1296–306, 2013.CrossRefGoogle ScholarPubMed
Adityanjee, Y.A., Aderibigbe, D., Theodoridis, , and Vieweg, W. V., Dementia praecox to schizophrenia: the first 100 years, Psychiatry and Clinical Neurosciences, 53, 437–48, 1999.CrossRefGoogle ScholarPubMed
Ebert, A. and Bar, K.-J., Emil Kraepelin: a pioneer of scientific understanding of psychiatry and psychopharmacology, Indian Journal of Psychiatry, 52, 191–2, 2010.Google Scholar
Jablensky, A., The diagnostic concept of schizophrenia: its history, evolution, and future prospects, Dialogues in Clinical Neuroscience, 12, 271–87, 2010.CrossRefGoogle ScholarPubMed
SAMHSA, SAMHSA's Working Definition of Recovery, Rockville, MD: SAMHSA, 2012.Google Scholar
Cohen, C., Freeman, K., Ghoneim, D., et al., Advances in the conceptualization and study of schizophrenia in later life, Psychiatric Clinics of North America, 41, 3953, 2018.CrossRefGoogle ScholarPubMed
Jeste, D.V., Wolkowitz, O.M., and Palmer, B.W., Divergent trajectories of physical, cognitive, and psychosocial aging in schizophrenia, Schizophrenia Bulletin, 37, 451–5, 2011.CrossRefGoogle ScholarPubMed
Cohen, C.I. and Iqbal, M., A longitudinal study of remission among older adults with schizophrenia spectrum disorder, American Journal of Geriatric Psychiatry, 22, 450–8, 2014.CrossRefGoogle ScholarPubMed
Diwan, S., Cohen, C.I., Bankole, A., et al., Depression in older adults with schizophrenia spectrum disorders: prevalence and associated factors, American Journal of Geriatric Psychiatry, 12, 991–8, 2007.Google Scholar
American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, 5th edn., Arlington, VA: American Psychiatric Publishing, 2013.Google Scholar
Kay, S., Opler, L., and Fiszbein, A., Positive and Negative Syndrome Scale User's Manual, North Tonawanda, NY: Multi-Health Systems, 1992.Google Scholar
Radloff, J.S., The CES-D scale: a self-report depression scale for research in the general population, Journal of Applied Psychological Measurement, 1, 385401, 1977.CrossRefGoogle Scholar
Coblentz, J.M., Mattis, S., Zingesser, L.H., et al., Presenile dementia: clinical aspects and evaluation of cerebrospinal fluid dynamics, Archives of Neurology, 29, 299308, 1973.CrossRefGoogle ScholarPubMed
Liberman, R.P., Recovery from schizophrenia: a concept in search of research, Pychiatric Services, 56, 735–42, 2005.Google ScholarPubMed
Andreasen, N.C., Carpenter, W.T., Kane, J.M., et al., Remission in schizophrenia: proposed criteria and rationale for consensus, American Journal of Psychiatry, 162, 441–9, 2005.CrossRefGoogle ScholarPubMed
Wong, Y.I. and Soloman, P.L., Community integration of persons with psychiatric disabilities in supportive independent housing: a conceptual model and methological considerations, Mental Health Services Research, 4, 1328, 2002.CrossRefGoogle Scholar
Moos, R.H., Evaluating Treatment Environments: The Quality of Psychiatric and Substance Abuse Programs, 2nd edn., New Brunswick, NJ: Transaction, 1997.Google Scholar
Abdallah, C., Cohen, C.I., Sanchez-Almira, M., et al., Community integration and associated factors among older adults with schizophrenia, Psychiatric Services, 12, 1642–8, 2009.Google Scholar
Strawbridge, W.J., Wallhagen, M.I., and Cohen, R.D., Successful aging and well being: self-rated compared with Rowe and Kahn, Gerontologist, 42, 727–33, 2002.CrossRefGoogle ScholarPubMed
Roew, J.W. and Kahn, R.L., Human aging: usual and successful, Science, 237, 143–9, 1987.Google Scholar
Ibrahim, F., Cohen, C.I., and Ramirez, P.M., Successful aging in older adults with schizophrenia: prevalence and associated factors, American Journal of Geriatric Psychiatry, 18, 879–86, 2010.CrossRefGoogle ScholarPubMed
Leung, W.W., Bowie, C.R., and Harvey, P.D., Functional implications of neuropsychological normality and symptom remission in older outpatients diagnosed with schziophrenia: a cross-sectional study, Journal of the International Neuropsycholical Society, 14, 479–88, 2008.Google Scholar
Meesters, P.D., Comijs, H.C., de Haan, L., et al., Symptomatic remission and associated factors in a catchment area based population of older patients with schizophrenia, Schizophrenia Research, 126, 237–44, 2011.CrossRefGoogle Scholar
Mosolov, S.N., Potapov, A.A., and Ushakov, U.V., Remission in schizophrenia: results of cross-sectional with 6 month follow-up period and 1-year observational therapeutic studies in an outpatient popuation, Annals of General Psychiatry, 11, 110, 2012.CrossRefGoogle Scholar
Harrison, G., Hopper, K., Craig, T., et al., Recovery from psychotic illness: a 15- and 25-year international follow-up study, British Journal of Psychiatry, 178, 506–17, 2001.CrossRefGoogle ScholarPubMed
Harding, C., Changes in schizophrenia across time: paradoxes, patterns, and predictors, in Schizophrenia Into Later Life, Arlington, VA: American Psychiatric Publishing, 2003, 1941.Google Scholar
Warner, R., Recovery from schizophrnenia, in Psychiatry and Political Economy, 3rd edn., Hove, East Sussex: Bruner-Routledge, 2004.Google Scholar
Robinson, D.G., Woerner, M.G., McMeniman, M., et al., Symptomatic and functional recovery from a first episode of schizophrenia of schizoaffective disorder, American Journal of Psychiatry, 161, 473479, 2004.CrossRefGoogle ScholarPubMed
Ciompi, L., Catamnestic long-term study on the course of life and aging of schizophrenics, Schizophrenia Bulletin, 6, 606–18, 1980.CrossRefGoogle ScholarPubMed
Auslander, L.A. and Jeste, D.V., Sustained remission of schizophrenia among community-dwelling older outpatients, American Journal of Psychiatry, 161, 1490–3, 2004.CrossRefGoogle ScholarPubMed
Depp, C.A. and Jeste, D.V., Definitions and predictors of successful aging: a comprehensive review of larger quantitative studies, American Journal of Geriatric Psychiatry, 14, 620, 2006.CrossRefGoogle ScholarPubMed
Cohen, C.I., Vahia, I., Reyes, P., et al., Schizophrenia in later life: clinical symptoms and well-being, Psychiatric Services, 59, 232–4, 2008.CrossRefGoogle Scholar
Belitsky, R. and McGlashan, T.H., The manifestations of schizophrenia in late life: a dearth of data, Schizophrenia Bulletin, 19, 683–5, 1993.CrossRefGoogle ScholarPubMed
Tandon, R., Nasrallah, H.A., and Keshavan, M.S., Schizophrenia, “just the facts.” 4. Clinical features and conceptualization, Schizophrenia Research, 110, 123, 2009.CrossRefGoogle Scholar
Emsley, R., Chiliza, B., Asmal, L., et al., The concepts of remission and recovery in schziophrenia, Current Opinion in Psychiatry, 114, e121, 2011.Google Scholar
Lang, F.U., Kosters, M., Lang, S., et al., Psychopathological long-term outcome of schizophrenia: a review, Acta Psychiatrica Scandinavica, 127, 173–82, 2013.CrossRefGoogle ScholarPubMed
Gasquet, I., Haro, J.M., Tcherny-Lessenot, S., et al., Remission in the outpatient care of schizophrenia: 3-year results from the Schizophrenia Outpatient Health Outcomes (SOHO) study in France, European Psychiatry, 23, 491–6, 2008.CrossRefGoogle ScholarPubMed
Bobes, J., Ciudad, A., Alvarez, E., et al, Recovery from schizophrenia: results from a 1-year follow-up observational study of patients in symptomatic remission, Schziophrenia Research, 115, 5866, 2009.CrossRefGoogle ScholarPubMed
Ucok, A., Serbest, S., and Kandemir, P. E., Remission after first-episode schizophrenia: results of a long-term follow-up study, Psychiatry Research, 189, 33–7, 2011.CrossRefGoogle Scholar
Conley, R.R., Ascher-Svanum, H., Zhu, B., et al., The burden of depressive symptoms in the long-term treatment of patients with schizophrenia, Schizophrenia Research, 90, 186–97, 2007.CrossRefGoogle ScholarPubMed
Lako, I.M., Taxis, K., Bruggerman, R., et al., The course of depressive symptoms and prescribing patterns of antidepressants in schizophrenia in a one year follow-up study, European Psychiatry, 27, 240–4, 2012.CrossRefGoogle Scholar
Sands, J.R. and Harrow, M., Depression during the longitudinal course of schizophrenia, Schizophrenia Bulletin, 25, 157–71, 1999.CrossRefGoogle ScholarPubMed
Cohen, C.I. and Ryu, H.H., A longitudinal study of the outcome and associated factors of subsyndromal and syndromal depression in community-dwelling older adults with schizophrenia spectrum disorder, American Journal of Geriatric Psychiatry, 23, 925–33, 2015.CrossRefGoogle ScholarPubMed
Tsoutsoulas, C., Mulsant, B.H., Kalache, S.M., et al., The influence of medical burden severity and cognition on functional competence in older community-dwelling individuals with schizophrenia, Schizophrenia Research, 170, 330–5, 2016.CrossRefGoogle ScholarPubMed
Szoke, A., Trandafir, A., Dupont, M.-E., et al., A systematic review of longitudinal outcome studies of first-episode psychosis, British Journal of Psychiatry, 192, 248–57, 2008.Google Scholar
Keefe, R.S., A longitudinal course of cognitive impairment in schizophrenia: an examination of data from premorbid through posttreatment phases of illness, Journal of Clinical Psychiatry, 75, Suppl 2, 813, 2014.CrossRefGoogle Scholar
Thompson, W.K., Savla, G.N., Vahia, I.V., et al., Characterizing trajectories of cognitive functioning in older adults with schizophrenia: does method matter? Schizophrenia Research, 143, 90–6, 2013.CrossRefGoogle ScholarPubMed
Cohen, C.I. and Murante, T., A prospective analysis of the role of cognition in three models of aging and schizophrenia, Schizophrenia Research, 196, 22–8, 2018.CrossRefGoogle ScholarPubMed
Bergh, S., Hjorthoj, C., Sorensen, H. J., et al., Predictors and longitudinal course of cognitive functioning in schizophrenia spectrum disorder, 10 years after baseline: the OPUS study, Schizophrenia Research, 175, 5763, 2016.CrossRefGoogle Scholar
Green, M.F., Kern, R.S., and Heaton, R.K., Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS, Schizophrenia Research, 72, 4151, 2004.CrossRefGoogle ScholarPubMed
Velthorst, E., Fett, A.J., Reichenberg, A., et al., The 20-year longitudinal trajectories of social functioning in individuals with psychotic disorders, American Journal of Psychiatry, 174, 1075–85, 2017.CrossRefGoogle ScholarPubMed
Diaz-Caneja, C.M., Pina-Camacho, L., Rodriguez-Quiroga, A., et al., Predictors of outcome in early-onset psychosis: a systematic review, NPJ Schizophrenia, 1, 14005, 2015.CrossRefGoogle ScholarPubMed
Menezes, N.M., Arenovich, T., and Zipursky, R.B., A systematic review of longitudinal outcome studies, Psychological Medicine, 36, 1349–62, 2006.CrossRefGoogle ScholarPubMed
Jimenez, C., Ryu, H.H., Garcia-Aracena, E., and Cohen, C.I., Predictors of community integration in older adults with schizophrenia, in American Psychiatric Association Annual Meeting, Philadelphia, PA., 2012, Washington, D.C.: American Psychiatric Association, 2012.Google Scholar
Shmuckler, A.B., Gurovich, I.Y., Agius, M., and Zaytseva, Y., Long-term trajectories of cognitive deficits in schizophrenia: a critical overview, European Psychiatry, 30, 1002–10, 2015.Google Scholar

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