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Section 6 - Mental Health of Men in Later Life

Published online by Cambridge University Press:  10 March 2021

David Castle
Affiliation:
University of Melbourne
David Coghill
Affiliation:
University of Melbourne
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Print publication year: 2021

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References

References

American Psychiatric Association. 2013. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Arlington, VA: American Psychiatric Publishing.Google Scholar
Andersen, K., Launer, L. J., Dewey, M. E., et al. 1999. Gender differences in the incidence of AD and vascular dementia: The EURODEM Studies. Neurology, 53, 1992–7.Google Scholar
Anstey, K. J., Eramudugolla, R., Hosking, D. E., et al. 2015. Bridging the translation gap: from dementia risk assessment to advice on risk reduction. Journal of Prevention of Alzheimers Disease, 2, 189–98.Google Scholar
Ashby-Mitchell, K., Burns, R., Shaw, J., and Anstey, K. 2017. Proportion of dementia in Australia explained by common modifiable risk factors. Alzheimer’s Research and Therapy, 9, 11.Google Scholar
Bedard, M., Kuzik, R., Chambers, L. et al. 2005. Understanding burden differences between men and women caregivers: the contribution of care–recipient problem behaviors. International Psychogeriatrics, 17, 99118.Google Scholar
Booth, M. L., Owen, N., Bauman, A., Clavisi, O., and Leslie, E. 2000. Social-cognitive and perceived environment influences associated with physical activity in older Australians. Preventive Medicine, 31, 1522.Google Scholar
Canevelli, M., Quarata, F., Remiddi, F., et al. 2017. Sex and gender differences in the treatment of Alzheimer’s disease: a systematic review of randomized controlled trials. Pharmacological Research, 115, 218–23.Google Scholar
Chong, T. W. H., Loi, S. M., Lautenschlager, N. T., and Ames, D. A. 2016. Therapeutic advances and risk factor management: our best chance to tackle dementia? Medical Journal of Australia, 204, 91–2.Google Scholar
Curran, E., Chong, T., and Lautenschlager, N. 2018. Dementia – how to reduce the risk and impact. Medicine Today, 19, 1423.Google Scholar
Fauth, E. B. and Gibbons, A. 2014. Which behavioral and psychological symptoms of dementia are the most problematic? Variability by prevalence, intensity, distress ratings, and associations with caregiver depressive symptoms. International Journal of Geriatric Psychiatry, 29, 263–71.Google Scholar
Grasset, L., Brayne, C., Joly, P., et al. 2016. Trends in dementia incidence: Evolution over a 10-year period in France. Alzheimer’s and Dementia, 12, 272–80.Google Scholar
Guariguata, L., Whiting, D. R., Hambleton, I., et al. 2013. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Research and Clinical Practice, 103, 137–49.Google Scholar
Jones, S. A. V. and O’Brien, J. T. 2014. The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies. Psychological Medicine, 44, 673–83.Google Scholar
Kalaria, R. N., Maestre, G. E., Arizaga, R., et al. 2008. Alzheimer’s disease and vascular dementia in developing countries: prevalence, management, and risk factors. Lancet Neurology, 7, 812–26.Google Scholar
Keadle, S. K., McKinnon, R., Graubard, B. I., and Troiano, R. P. 2016. Prevalence and trends in physical activity among older adults in the United States: a comparison across three national surveys. Preventive Medicine, 89, 3743.Google Scholar
Laver, K., Cumming, R. G., Dyer, S. M., et al. 2016. Clinical practice guidelines for dementia in Australia. Medical Journal of Australia, 204, 191–3.Google Scholar
Livingston, G., Sommerlad, A., Orgeta, V., et al. 2017. Dementia prevention, intervention, and care. Lancet, 390, 2673–734.CrossRefGoogle ScholarPubMed
Livingston, G., Huntley, J., Sommerlad, A., et al. 2020. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet, 396, 413–46.Google Scholar
Loi, S., Chong, T., and Ames, D. 2017. Cognitive Screening for Dementia. In: Lautenbacher, S. and Gibson, S.J. (eds.) Pain in Dementia. Philadelphia: Wolters Kluwer Health.Google Scholar
Lovheim, H. Sandman, P., Karlsson, S., and Gustafson, Y. 2009. Sex difference in the prevalence of behavioral and psychological symptoms of dementia. International Psychogeriatrics, 21, 469–75.Google Scholar
Matthews, F. E., Arthur, A., Barnes, L. E., et al. 2016. A two-decade comparison of prevalence of dementia in individual aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II. Lancet, 382, 1405–12.Google Scholar
McKeith, I. G., Boeve, B. F., and Dickson, D. W. 2017. Diagnosis and management of dementia with Lewy bodies. Neurology, 89, 88100.Google Scholar
Mielke, M. M., Ferretti, M. T., Iulita, M. F., Hayden, K., and Khachaturian, A. S. 2018. Sex and gender in Alzheimer’s disease – does it matter? Alzheimer’s and Dementia, 14, 1101–3.Google Scholar
Mielke, M. M., Vemuri, P., and Rocca, W. A. 2014. Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences. Clinical Epidemiology, 6, 3748.Google Scholar
Neary, D., Snowden, J., and Mann, D. 2005. Frontotemporal dementia. Lancet Neurology, 4, 771–80.Google Scholar
Nebel, R. A., Aggarwal, N. T., Barnes, L. L., et al. 2018. Understanding the impact of sex and gender in Alzheimer’s disease: a call to action. Alzheimer’s and Dementia, 14, 1171–83.Google Scholar
Ng, M., Fleming, T., Robinson, M., et al. 2014. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet, 384, 766–81.Google Scholar
Norton, S., Matthews, F. E., Barnes, D. E., et al. 2014. Potential for primary prevention of Alzheimer’s disease: an analysis of population-based data. Lancet Neurology, 13, 788–94.Google Scholar
Perry-Young, L., Owen, G., Kelly, S., and Owens, C. 2018. How people came to recognise a problem and seek medical help for a person showing early signs of dementia: a systematic review and meta-ethnography. Dementia, 17, 3460.Google Scholar
Pillemer, S., Davis, J., and Tremont, G. 2018. Gender effects on components of burden and depression among dementia caregivers. Aging and Mental Health, 22(9), 1156–61.Google Scholar
Prince, M., Wimo, A., Guerchet, M., et al. 2015. World Alzheimer report 2015. The global impact of dementia: an analysis of incidence, prevalence, cost and trends. London: Alzheimer’s Disease International. Available at www.alz.co.uk/research/WorldAlzheimerReport2015.pdf (accessed September 2015).Google Scholar
Ridley, N. J., Draper, B., and Whithall, A. 2013. Alcohol-related dementia: an update of the evidence. Alzheimer’s Research and Therapy, 5, 3.Google Scholar
Rocca, W. A., Mielke, M. M., Vemuri, P., and Miller, V. M. 2014. Sex and gender differences in the causes of dementia: a narrative review. Maturitas, 79, 196201.Google Scholar
Satizabal, C. L., Beiser, A. S., Chouraki, V., et al. 2016. Incidence of dementia over three decades in the Framingham Heart Study. New England Journal of Medicine, 374, 523–32.Google Scholar
Schneider, L. S., Mangialasche, F., Andreasen, N., et al. 2014. Clinical trials and late-stage drug development for Alzheimer’s disease: an appraisal from 1984 to 2014. Journal of Internal Medicine, 275, 251–83.Google Scholar
Steel, Z. Marnane, C., Iranpour, C., et al. 2014. The global prevalence of common mental disorders: a systematic review and meta-analysis 1980–2013. International Journal of Epidemiology, 43, 476–93.Google Scholar
Theodore, R. F., Broadbent, J., Nagin, D., et al. 2015. Childhood to early–midlife systolic blood pressure trajectories – Early life predictors, effect modifiers, and adult cardiovascular outcomes. Hypertension, 66, 11081115.Google Scholar
Villemagne, V. L., Burnham, S., Bourgeat, P., et al. 2014. Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer’s disease: a prospective cohort study. Lancet Neurology, 12, 357–67.Google Scholar
World Health Organization. 2019. The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. Geneva: World Health Organization. https://icd.who.int/browse10/2019/en#/F00-F09Google Scholar
Wu, Y., Beiser, A. S., Breteler, M. M. B., et al. 2017. The changing prevalence and incidence of dementia over time – current evidence. Nature Reviews Neurology, 13, 327–40.Google Scholar
Zhao, Q., Tan, L, Wang, H., et al. 2016. The prevalence of neuropsychiatric symptoms in Alzheimer’s disease: a systematic review and meta-analysis. Journal of Affective Disorders, 190, 264–71.Google Scholar

References

Almeida, O. P. 2008. Vascular depression: myth or reality? Int Psychogeriatr, 20, 645–52.Google Scholar
Almeida, O. P. 2014. Prevention of depression in older age. Maturitas, 79, 136–41.Google Scholar
Almeida, O. P., Alfonso, H., Flicker, L., Hankey, G. J., and Norman, P. E. 2012a. Cardiovascular disease, depression and mortality: the Health In Men Study. Am J Geriatr Psychiatry, 20, 433–40.Google Scholar
Almeida, O. P. et al. 2012b. Anxiety, depression, and comorbid anxiety and depression: risk factors and outcome over two years. Int Psychogeriatr, 24, 1622–32.Google Scholar
Almeida, O. P. et al. 2012c. Factors associated with suicidal thoughts in a large community study of older adults. Br J Psychiatry, 201, 466–72.CrossRefGoogle Scholar
Almeida, O. P., Ford, A. H., Hankey, G. J., Yeap, B. B., Golledge, J., and Flicker, L. 2018a. Risk of dementia associated with psychotic disorders in later life: the health in men study (HIMS). Psychol Med, 1–11.Google Scholar
Almeida, O. P., Forstl, H., Howard, R., and David, A. S. 1993. Unilateral auditory hallucinations. Br J Psychiatry, 162, 262–4.Google Scholar
Almeida, O. P. et al. 2011. 24-month effect of smoking cessation on cognitive function and brain structure in later life. Neuroimage, 55, 1480–9.Google Scholar
Almeida, O. P., Hankey, G. J., Yeap, B. B., Golledge, J., and Flicker, L. 2017a. Depression as a modifiable factor to decrease the risk of dementia. Transl Psychiatry, 7, e1117.Google Scholar
Almeida, O. P., Hankey, G. J., Yeap, B. B., Golledge, J., and Flicker, L. 2018b. Older men with bipolar disorder: clinical associations with early and late onset illness. Int J Geriatr Psychiatry, 33(12), 1613–19.Google Scholar
Almeida, O. P., Hankey, G. J., Yeap, B. B., Golledge, J., and Flicker, L. 2018c. Substance use among older adults with bipolar disorder varies according to age at first treatment contact. J Affect Disord, 239, 269–73.Google Scholar
Almeida, O. P., Hankey, G. J., Yeap, B. B., Golledge, J., Hill, K. D., and Flicker, L. 2017b. Depression among nonfrail old men is associated with reduced physical function and functional capacity after 9 years follow-up: the Health in Men Cohort Study. J Am Med Dir Assoc, 18, 65–9.Google Scholar
Almeida, O. P., Hankey, G. J., Yeap, B. B., Golledge, J., Norman, P. E., and Flicker, L. 2014. Mortality among people with severe mental disorders who reach old age: a longitudinal study of a community-representative sample of 37,892 men. PLoS One, 9, e111882.Google Scholar
Almeida, O. P., Hankey, G. J., Yeap, B. B., Golledge, J., Norman, P. E., and Flicker, L. 2015. Depression, frailty, and all-cause mortality: a cohort study of men older than 75 years. J Am Med Dir Assoc, 16, 296300.Google Scholar
Almeida, O. P., Howard, R. J., Levy, R., and David, A. S. 1995. Psychotic states arising in late life (late paraphrenia). The role of risk factors. Br J Psychiatry, 166, 215–28.Google Scholar
Almeida, O. P., Hulse, G. K., Lawrence, D., and Flicker, L. 2002. Smoking as a risk factor for Alzheimer’s disease: contrasting evidence from a systematic review of case-control and cohort studies. Addiction, 97, 1528.Google Scholar
Almeida, O. P., McCaul, K., Hankey, G. J., Yeap, B. B., Golledge, J., and Flicker, L. 2016a. Affective disorders, psychosis and dementia in a community sample of older men with and without Parkinson’s disease. PLoS One, 11, e0163781.Google Scholar
Almeida, O. P., McCaul, K., Hankey, G. J., Yeap, B. B., Golledge, J., and Flicker, L. 2016b. Risk of dementia and death in community-dwelling older men with bipolar disorder. Br J Psychiatry, 209, 121–6.CrossRefGoogle ScholarPubMed
Almeida, O. P., McCaul, K., Hankey, G. J., Yeap, B. B., Golledge, J., and Flicker, L. 2016c. Suicide in older men: the Health in Men Cohort Study (HIMS). Prev Med, 93, 33–8.Google Scholar
Almeida, O. P., McCaul, K., Hankey, G. J., Yeap, B. B., Golledge, J., and Flicker, L. 2017c. Excessive alcohol consumption increases mortality in later life: a genetic analysis of the health in men cohort study. Addict Biol, 22, 570578.Google Scholar
Almeida, O. P. et al. 2016d. Duration of diabetes and its association with depression in later life: The Health in Men Study (HIMS). Maturitas, 86, 39.Google Scholar
Almeida, O. P. et al. 2012d. A randomized trial to reduce the prevalence of depression and self-harm behavior in older primary care patients. Ann Fam Med, 10, 347–56.Google Scholar
Almeida, O. P., and Xiao, J. 2007. Mortality associated with incident mental health disorders after stroke. Aust N Z J Psychiatry, 41, 274–81.Google Scholar
Almeida, O. P., Yeap, B. B., Hankey, G. J., Jamrozik, K., and Flicker, L. 2008. Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men. Arch Gen Psychiatry, 65, 283–9.Google Scholar
Australian Institute of Health and Welfare. 2017. Older Australia at a glance. Canberra: Australian Institute of Health and Welfare and the Dept. of Health and Ageing. www.aihw.gov.au › older-peopleGoogle Scholar
Ayerbe, L., Ayis, S., Wolfe, C. D., and Rudd, A. G. 2013. Natural history, predictors and outcomes of depression after stroke: systematic review and meta-analysis. Br J Psychiatry, 202, 1421.Google Scholar
Beekman, A. T., et al. 2002. The natural history of late-life depression: a 6-year prospective study in the community. Arch Gen Psychiatry, 59, 605–11.Google Scholar
Beer, C. et al. 2011. Quality use of medicines and health outcomes among a cohort of community dwelling older men: an observational study. Br J Clin Pharmacol, 71, 592–9.Google Scholar
Bosboom, P. R., Alfonso, H., and Almeida, O. P. 2013. Determining the predictors of change in quality of life self-ratings and carer-ratings for community-dwelling people with Alzheimer disease. Alzheimer Dis Assoc Disord, 27, 363–71.Google Scholar
Bostwick, J. M., Pabbati, C., Geske, J. R., and McKean, A. J. 2016. Suicide attempt as a risk factor for completed suicide: even more lethal than we knew. Am J Psychiatry, 173, 10941100.Google Scholar
Buchtemann, D., Luppa, M., Bramesfeld, A., and Riedel-Heller, S. 2012. Incidence of late-life depression: a systematic review. J Affect Disord, 142, 172–9.Google Scholar
Calof, O. M. et al. 2005. Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials. J Gerontol A Biol Sci Med Sci, 60, 1451–7.Google Scholar
Chi, S., Wang, C., Jiang, T., Zhu, X. C., Yu, J. T., and Tan, L. 2015. The prevalence of depression in Alzheimer’s disease: a systematic review and meta-analysis. Curr Alzheimer Res, 12, 189–98.Google Scholar
Coryell, W., Fiedorowicz, J., Solomon, D., and Endicott, J. 2009. Age transitions in the course of bipolar I disorder. Psychol Med, 39, 1247–52.Google Scholar
Cuijpers, P., and Smit, F. 2002. Excess mortality in depression: a meta-analysis of community studies. J Affect Disord, 72, 227–36.Google Scholar
Cuijpers, P., van Straten, A.,, Andersson, G. and van Oppen, P. 2008. Psychotherapy for depression in adults: a meta-analysis of comparative outcome studies. J Consult Clin Psychol, 76, 909–22.Google Scholar
Cuijpers, P., van Straten, A., and Warmerdam, L. 2007. Behavioral activation treatments of depression: a meta-analysis. Clin Psychol Rev, 27, 318–26.Google Scholar
Cusack, K. et al. 2016. Psychological treatments for adults with posttraumatic stress disorder: a systematic review and meta-analysis. Clin Psychol Rev, 43, 128–41.Google Scholar
Djernes, J. K. 2006. Prevalence and predictors of depression in populations of elderly: a review. Acta Psychiatr Scand, 113, 372–87.Google Scholar
Ford, A. H. et al. 2016. Prospective longitudinal study of testosterone and incident depression in older men: The Health in Men Study. Psychoneuroendocrinology, 64, 5765.Google Scholar
GBD Causes of Death Collaborators. 2017. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet, 390, 11511210.Google Scholar
Geduldig, E. T., and Kellner, C. H. 2016. Electroconvulsive therapy in the elderly: new findings in geriatric depression. Curr Psychiatry Rep, 18, 40.Google Scholar
Gilbody, S. et al. 2017. Effect of collaborative care vs usual care on depressive symptoms in older adults with subthreshold depression: the CASPER Randomized Clinical Trial. JAMA, 317, 728–37.Google Scholar
Goncalves, D. C., and Byrne, G. J. 2012. Interventions for generalized anxiety disorder in older adults: systematic review and meta-analysis. J Anxiety Disord, 26, 111.Google Scholar
Hackett, M. L., Anderson, C. S., House, A., and Halteh, C. 2008a. Interventions for preventing depression after stroke. Cochrane Database Syst Rev, CD003689.Google Scholar
Hackett, M. L., Anderson, C. S., House, A., and Xia, J. 2008b. Interventions for treating depression after stroke. Cochrane Database Syst Rev, CD003437.Google Scholar
Hackett, M. L., Kohler, S., O’Brien, J. T., and Mead, G. E. 2014. Neuropsychiatric outcomes of stroke. Lancet Neurol, 13, 525–34.CrossRefGoogle ScholarPubMed
Hegeman, J. M., Kok, R. M., van der Mast, R. C., and Giltay, E. J. 2012. Phenomenology of depression in older compared with younger adults: meta-analysis. Br J Psychiatry, 200, 275–81.Google Scholar
Howard, R. et al. 2018. Antipsychotic treatment of very late-onset schizophrenia-like psychosis (ATLAS): a randomised, controlled, double-blind trial. Lancet Psychiatry, 5, 553–63.Google Scholar
Jamrozik, K. et al. 2011. Women who smoke like men die like men who smoke: findings from two Australian cohort studies. Tob Control, 20, 258–65.Google Scholar
Katzman, M. A., et al. 2014. Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders. BMC Psychiatry, 14 (suppl. 1), S1.Google Scholar
Kuerbis, A., Sacco, P., Blazer, D. G., and Moore, A. A. 2014. Substance abuse among older adults. Clin Geriatr Med, 30, 629–54.Google Scholar
Lawrence, D., Almeida, O. P., Hulse, G. K., Jablensky, A. V., and Holman, C. D. 2000. Suicide and attempted suicide among older adults in Western Australia. Psychol Med, 30, 813–21.Google Scholar
Mitchell, A. J., Vaze, A., and Rao, S. 2009. Clinical diagnosis of depression in primary care: a meta-analysis. Lancet, 374, 609–19.Google Scholar
Mottram, P., Wilson, K., and Strobl, J. 2006. Antidepressants for depressed elderly. Cochrane Database Syst Rev, CD003491.Google Scholar
Norton, S., Matthews, F. E., Barnes, D. E., Yaffe, K., and Brayne, C. 2014. Potential for primary prevention of Alzheimer’s disease: an analysis of population-based data. Lancet Neurol, 13, 788–94.Google Scholar
O’Connell, H., Chin, A. V., Cunningham, C., and Lawlor, B. 2003. Alcohol use disorders in elderly people – redefining an age old problem in old age. BMJ, 327, 664–7.Google Scholar
Perugi, G., Medda, P., Toni, C., Mariani, M. G., Socci, C., and Mauri, M. 2017. The role of electroconvulsive therapy (ect) in bipolar disorder: effectiveness in 522 patients with bipolar depression, mixed-state, mania and catatonic features. Curr Neuropharmacol, 15, 359–71.CrossRefGoogle ScholarPubMed
Pirkis, J. et al. 2009. The community prevalence of depression in older Australians. J Affect Disord, 115, 5461.Google Scholar
Pope, H. G. Jr., Cohane, G. H., Kanayama, G., Siegel, A. J., and Hudson, J. I. 2003. Testosterone gel supplementation for men with refractory depression: a randomized, placebo-controlled trial. Am J Psychiatry, 160, 105–11.Google Scholar
Prince, M., et al. 2007. No health without mental health. Lancet, 370, 859–77.Google Scholar
Reynolds, K., Pietrzak, R. H., El-Gabalawy, R., Mackenzie, C. S., and Sareen, J. 2015. Prevalence of psychiatric disorders in U.S. older adults: findings from a nationally representative survey. World Psychiatry, 14, 7481.Google Scholar
Sajatovic, M., Blow, F. C., Ignacio, R. V., and Kales, H. C. 2004. Age-related modifiers of clinical presentation and health service use among veterans with bipolar disorder. Psychiatr Serv, 55, 1014–21.Google Scholar
Sajatovic, M., et al. 2015. A report on older-age bipolar disorder from the International Society for Bipolar Disorders Task Force. Bipolar Disord, 17, 689704.Google Scholar
Scott, J., Greenwald, B. S., Kramer, E., and Shuwall, M. 2011. Atypical (second generation) antipsychotic treatment response in very late-onset schizophrenia-like psychosis. Int Psychogeriatr, 23, 742–8.Google Scholar
Sheeran, T., Greenberg, R. L., Davan, L. A., Dealy, J. A., Young, R. C., and Bruce, M. L. 2012. A descriptive study of older bipolar disorder residents living in New York City’s adult congregate facilities. Bipolar Disord, 14, 756–63.Google Scholar
Shores, M. M., Kivlahan, D. R., Sadak, T. I., Li, E. J., and Matsumoto, A. M. 2009. A randomized, double-blind, placebo-controlled study of testosterone treatment in hypogonadal older men with subthreshold depression (dysthymia or minor depression). J Clin Psychiatry, 70, 1009–16.Google Scholar
Snowdon, J., and Baume, P. 2002. A study of suicides of older people in Sydney. Int J Geriatr Psychiatry, 17, 261269.Google Scholar
Snowdon, J., Draper, B., and Wyder, M. 2011. Age variation in the prevalence of DSM-IV disorders in cases of suicide of middle-aged and older persons in Sydney. Suicide Life Threat Behav, 41, 465–70.Google Scholar
Snyder, P. J. et al. 2016. Effects of testosterone treatment in older men. N Engl J Med, 374, 611–24.Google Scholar
Stringhini, S. et al. 2017. Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1.7 million men and women. Lancet, 389, 1229–37.Google Scholar
Taylor, M. H., and Grossberg, G. T. 2012. The growing problem of illicit substance abuse in the elderly: a review. Prim Care Companion CNS Disord, 14.Google Scholar
Tham, A., Jonsson, U., Andersson, G., Soderlund, A., Allard, P., and Bertilsson, G. 2016. Efficacy and tolerability of antidepressants in people aged 65 years or older with major depressive disorder – a systematic review and a meta-analysis. J Affect Disord, 205, 112.Google Scholar
United Nations. 2015. Department of Economic and Social Affairs. Population Division. World population ageing 2015. New York: United Nations, Dept. of Economic and Social Affairs, Population Division.Google Scholar
United Nations. 2017. Department of Economic and Social Affairs. Population Division. World Population Prospects: The 2017 Revision – Key Findings and Advance Tables. Working Paper No. ESA/P/WP/248. New York: United Nations, Dept. of Economic and Social Affairs, Population Division.Google Scholar
van Grootheest, D. S., Beekman, A. T., Broese van Groenou, M. I., and Deeg, D. J. 1999. Sex differences in depression after widowhood. Do men suffer more? Soc Psychiatry Psychiatr Epidemiol, 34, 391–8.Google Scholar
West, N. A., Severtson, S. G., Green, J. L., and Dart, R. C. 2015. Trends in abuse and misuse of prescription opioids among older adults. Drug Alcohol Depend, 149, 117–21.Google Scholar
Wolitzky-Taylor, K. B., Castriotta, N., Lenze, E. J., Stanley, M. A., and Craske, M. G. 2010. Anxiety disorders in older adults: a comprehensive review. Depress Anxiety, 27, 190211.Google Scholar
Xu, L., Freeman, G., Cowling, B. J., and Schooling, C. M. 2013. Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials. BMC Med, 11, 108.Google Scholar
Young, R. C. et al. 2017. GERI-BD: a randomized double-blind controlled trial of lithium and divalproex in the treatment of mania in older patients with bipolar disorder. Am J Psychiatry, 174, 1086–93.Google Scholar

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