Lesbian, gay, bisexual, trans, and intersex persons are at particular risk of being targeted because of their gender or sexual preference. Discrimination against LGBTI persons may be based on sexual orientation, gender identity, gender expression, or sex characteristics. The chapter looks first at the right to life of LGBTI persons under global standards. This comprises extrajudicial executions by State agents, the failure to exercise due diligence in protecting LGBTI persons, and the imposition of the death penalty for homosexual activity. In nine States, the penal code prescribes the death penalty as a possible judicial sanction for same-sex sexual activity.