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Chapter 6 - The Fault in Our Models

Published online by Cambridge University Press:  29 June 2020

Alberto Espay  and
Benjamin Stecher
Alberto Espay
Affiliation:
University of Cincinnati
Benjamin Stecher
Affiliation:
Educational Consultant and Healthcare Advocate
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Summary

Aggregated brain proteins are enshrined in a century-old model of disease, the clinico-pathology model. The clinico part includes the diversity of symptoms and signs that are the expression of many types of abnormalities of brain aging: stooped posture, memory difficulties, problems with urination, depression. The pathology part is what we assume brings it all together. If a brain after death is seeded by plaques containing beta-amyloid and neurons filled with tangles of tau, these clinical signs can be safely assumed to belong to one disease: Alzheimer’s.

Type
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Brain Fables
The Hidden History of Neurodegenerative Diseases and a Blueprint to Conquer Them
 , pp. 57 - 70
Publisher: Cambridge University Press
Print publication year: 2020

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