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Debate 44A - What is the Best Management Option for Young Women with Stage IB2 Cervical Cancer Who Wish to Preserve Fertility?

Abdominal Radical Trachelectomy

from Section V - Cervical Cancer

Published online by Cambridge University Press:  20 July 2023

Dennis S. Chi
Affiliation:
Memorial Sloan-Kettering Cancer Center, New York
Nisha Lakhi
Affiliation:
Richmond University Medical Center, Staten Island
Nicoletta Colombo
Affiliation:
University of Milan-Bicocca
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Summary

The radical trachelectomy procedure is now recognized as a “standard of care” option for young women with early-stage cervical cancer who wish to preserve fertility. However, the oncologic safety of this approach has mostly been validated for small lesions measuring <2 cm. The optimal management for patients with larger lesions who wish to preserve fertility remains unsettled and there is currently no standard of care. There are essentially two alternatives: either to proceed with upfront radical trachelectomy or neo-adjuvant chemotherapy (NACT) followed by fertility-sparing surgery (FSS). The balance between oncologic outcomes and surgical morbidity versus fertility and obstetrical outcomes need to be carefully balanced and addressed. We wish to present to the readers with arguments for and against both options in the hopes that it will help clinicians decide which is the best option for their individual patients.

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Publisher: Cambridge University Press
Print publication year: 2023

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References

Roy, M, et al. Pregnancies after radical vaginal trachelectomy for early-stage cervical cancer, Am J Obstet Gynecol 1998;179:14911496.CrossRefGoogle ScholarPubMed
Bhosale, PR, et al. Is MRI helpful in assessing the distance of the tumour from the internal os in patients with cervical cancer below FIGO Stage IB2? Clin Radiol 2016;71:515522.CrossRefGoogle ScholarPubMed
van Kol KGG, et al. Abdominal radical trachelectomy versus chemotherapy followed by vaginal radical trachelectomy in stage 1B2 (FIGO 2018) cervical cancer. A systematic review on fertility and recurrence rates. Gynecol Oncol 2019;155:515521.Google Scholar
Burnett, AF. Radical trachelectomy with laparoscopic lymphadenectomy: review of oncologic and obstetrical outcomes, Curr Opin Obstet Gynecol 2006;18:813.CrossRefGoogle ScholarPubMed
Plante, M, et al. FIGO 2018 stage IB2 (2–4 cm) Cervical cancer treated with Neo-adjuvant chemotherapy followed by fertility Sparing Surgery (CONTESSA); Neo-Adjuvant Chemotherapy and Conservative Surgery in Cervical Cancer to Preserve Fertility (NEOCON-F). A PMHC, DGOG, GCIG/CCRN and multicenter study. Int J Gynecol Cancer 2019;29:969975.CrossRefGoogle Scholar

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