Book contents
- Infertility in the Male
- Infertility in the Male
- Copyright page
- Contents
- Contributors
- Foreword
- Abbreviations
- Introduction
- Section 1 Scientific Foundations of Male Infertility
- Section 2 Clinical Evaluation of the Infertile Male
- Section 3 Laboratory Diagnosis of Male Infertility
- Section 4 Treatment of Male Infertility
- Section 5 Health Care Systems and Culture
- Chapter 28 Mental Health and Male Reproduction
- Chapter 29 Legal Issues and Male Reproduction
- Chapter 30 Male Reproduction in the Transgender Patient
- Chapter 31 Global and Cultural Aspects of Male Reproductive Care
- Index
- References
Chapter 30 - Male Reproduction in the Transgender Patient
from Section 5 - Health Care Systems and Culture
Published online by Cambridge University Press: 08 July 2023
Book contents
- Infertility in the Male
- Infertility in the Male
- Copyright page
- Contents
- Contributors
- Foreword
- Abbreviations
- Introduction
- Section 1 Scientific Foundations of Male Infertility
- Section 2 Clinical Evaluation of the Infertile Male
- Section 3 Laboratory Diagnosis of Male Infertility
- Section 4 Treatment of Male Infertility
- Section 5 Health Care Systems and Culture
- Chapter 28 Mental Health and Male Reproduction
- Chapter 29 Legal Issues and Male Reproduction
- Chapter 30 Male Reproduction in the Transgender Patient
- Chapter 31 Global and Cultural Aspects of Male Reproductive Care
- Index
- References
Summary
Male-to-female transgenderism is defined as identification as female, given one’s natal or biological sex as male [1]. Recent studies have shown that there is an increase in the number of people who identify as transgender [2]. As both the prevalence and insurance coverage have increased, more patients are having gender-affirming surgery (GAS). Both hormonal therapy and surgery can significantly impact future fertility. Medical providers should be aware of treatment impact, fertility preservation (FP) options, and barriers that may prevent infertility.
- Type
- Chapter
- Information
- Infertility in the Male , pp. 525 - 533Publisher: Cambridge University PressPrint publication year: 2023
References
Li, K, Rodriguez, D, Gabrielsen, JS, Centola, GM, Tanrikut, C. Sperm cryopreservation of transgender individuals: trends and findings in the past decade. Andrology 2018;6:860–4.Google Scholar
FLores, AR, Herman, JL, Gates, GL, Brown, TNT. How many adults identify as transgender in the United States? 2016. Available from: williamsinstitute.law.ucla.edu/publications/trans-adults-united-states/.Google Scholar
Pan, S, Honig, SC. Gender-affirming surgery: current concepts. Curr Urol Rep 2018;19:62.Google Scholar
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-5, 5th ed. Washington, DC: American Psychiatric Association, 2013.Google Scholar
Coleman, E, Bockting, W, Botzer, M, et al. Standards of care for the health of transexual transgender and gender nonconforming people, version 7. International Journal of Transgenderism 2012;13:165–232.Google Scholar
FLores, AR, Herman, JL, Gates, GL, Brown, TNT. How many adults identify as transgender in the United States? 2016. Available from: williamsinstitute.law.ucla.edu/publications/trans-adults-united-states/.Google Scholar
Van Beijsterveldt, CEM, Hudziak, JJ, Boomsma, DI. Genetic and environmental influences on cross-gender behavior and relation to behavior problems: a study of Dutch twins at ages 7 and 10 years. Arch Sex Behav 2006;35:647–58.Google Scholar
Shields, JP, Cohen, R, Glassman, JR, Whitaker, K, Franks, H, Bertolini, I. Estimating population size and demographic characteristics of lesbian, gay, bisexual, and transgender youth in middle school. J Adolesc Health 2013;52:248–50.Google Scholar
Dhejne, C, Oberg, K, Arver, S, Landen, M. An analysis of all applications for sex reassigment surgery in Sweden, 1960–2010: prevalence, incidence, and regrets. Arch Sex Behav 2014;43:1535–45.Google Scholar
Cohen, W, Sangalang, A, Dalena, M, Avyala, H, Keith, J. Navigating insurance policies in the United States for gender-affirming surgery. Plast Reconstr Surg Glob Open 2019;7:e2564.Google Scholar
Canner, JK, Harfouch, H, Kodadek, LM, Pelaez, D, Coon, D, Offodile, AC. Temporal trends in gender-affirming surgery among transgender patients in the United States. JAMA Surg 2018;153:609–16.Google Scholar
Pan, S, Honig, SC. Gender-affirming surgery: current concepts. Curr Urol Rep 2018;19:62.Google Scholar
Garcia, M TP, Nim, C, et al. Genital gender affirming surgery for transgender patients. AUA Update Series 2017.2017;36:43–54.Google Scholar
Netto, RR, Hintz, F, Krege, S, Rubben, H, Vom Dorp, F. Gender reassignment surgery-a 13 year review of surgical outcomes. Int Braz J Urol 2012;38:97–107.CrossRefGoogle Scholar
Rehman, J, Melman, A. Formation of neoclitoris from glans penis by reduction glansplasty with preservation of neurovascular bundle in male-to-female gender surgery: functional and cosmetic outcome. J Urol 1999;161:200–6.Google Scholar
Rude, T. V9–06: robotic assisted penile inversion vaginoplasty: a novel technique. J Urol 2017;4:e1058.Google Scholar
Jacoby, A, Maliha, M, Granieri, MA, Cohen, O, Dy, GW, Blubond-Langner, R, Zhao, LC. Robotic Davydov peritoneal flap vaginoplasty for augmentation of vaginal depth in feminizing vaginoplasty. J Urol.2019;6:1171–6.Google Scholar
Bouman, MB, van der Sluis, WB, Hamstra, LE, et al. Patient-reported esthetic and functional outcomes of priamry total laparoscopic intestinal vaginoplasty in transgender women with penoscrotal hypoplasia. J Sex Med 2016;13:1438–44.Google Scholar
Gaither, TW, Awad, MA, Osterberg, CE, et al. Postoeprative complications folllowing primary penile inversion vaginoplasty among 330 male to female transgender patients. J Urol 2018;199:760–5.Google Scholar
Hembree, WC, Cohen-Kettenis, PT, Gooren, L, et al. Endocrine treatment of gender-dysphoric/gender-incongruent persons: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2017;102:3869–903.Google Scholar
Mattawanon, N, Spencer, JB, Schirmer, DA, Tangpricha, V. Fertility preservation option in transgender people: a review. Rev Endocr Metab Disord 2018;19:231–42.Google Scholar
Martinez, F; International Society for Fertility Preservation–ESHRE–ASRM Expert Working Group. Update on fertility preservation from the Barcelona International Society for Fertility Preservation–ESHRE–ASRM 2015 expert meeting: indications, results and future perspectives. Fertil Steril 2017;108:407–15.Google Scholar
Tornello, SL, Bos, H. Parenting intentions among transgender individuals. LGBT Health 2016;4:115–20.Google Scholar
Wierckx, K, Caenegem, EV, Pennings, G, et al. Reproductive wish in transsexual men. Hum Reprod 2012;27:483–7.Google Scholar
Wierckx, K, Stuyver, I, Weyers, S, et al. Sperm freezing in transsexual women. Arch Sex Behav 2012;41:1069–71.Google Scholar
Nahata, L, Tishelman, AC, Caltabellotta, NM, Quinn, GP. Low fertility preservation utilization among transgender youth. J Adolesc Health 2017;61:40–4.Google Scholar
Chen, D, Simons, L, Johnson, EK, Lockart, BA, Finlayson, C. Fertility preservation for transgender adolescents. J Adolesc Health 2017;61:120–3.Google Scholar
Mattawanon, N, Spencer, JB, Schirmer, DA, Tangpricha, V. Fertility preservation options in transgender people: a review. Rev Endocr Metab Disord 2018;19:231–42.Google Scholar
Linde, R, Doelle, GC, Alexander, N, et al. Reversible inhibition of testicular steroidogenesis and spermatogenesis by potent gonadotropin releasing hormone agonists in normal men: an approach toward the development of a male contraceptive. N Engl J Med 305:663–7.Google Scholar
Behre, HM, Nashan, D, Hubert, W, Nieschlag, E. Depot gonadotropin-releasing hormone agonist blunts the androgen induced supression of spermatogenesis in a clinical trial of male contraception. J Clin Endocrinol Metab 1992;74:84–90.Google Scholar
Schneider, F, Kliesch, S, Schlatt, S, Neuhaus, N. Andrology of male to female transsexuals:influence of cross sex hormone therapy on testicular function. Andrology 5:873–80.Google Scholar
Meriggiola, MC, Bremner, WJ, Costantino, A, Di Cintio, G, Flamigni, C. Low dose of cyproterone acetate and testosterone enanthate for contraception in men. Hum Reprod 1998;13:1225–9.Google Scholar
Corvol, P, MEnard, J, Freifeld, M, Mahoudeau, J. Antiandrogenic effect of spironolactone: mechanisms of action. Endocrinology 1975;97:52–8.Google Scholar
Kose, MG, Peskircioglu, CL, Caylak, B. Effects of angiogenesis inhibition by spironolactone on isolated vas deferens contractility in experimental varicoele rat models in rats. Urology 2012;80:816–21.Google Scholar
Tangpricha, V. Oestrogen and antoandrogen therapy in transgender women. Lancet 2017;5:291–300.Google Scholar
Kaushik, MC, Sehgal, N, Nandan, D. AR versus ER (alpha) expression in the testis and pituitary following chronic estrogen administration in adult rat. Syst Biol Reprod Med 2010;56:420–30.Google Scholar
Thiagaraj, D, Loganath, A, Peh, KL, Kottegoda, SR, Ratnam, SS. Histopathology of the testes from male transsexuals on estrogen therapy. Ann Acad Med Singap 1987;16:347–8.Google Scholar
Hamada, A, Wierckx, K, T’Sjoen, G, et al. Semen characteristics of transgender women referred for sperm banking before sex transition: a case series. Andrologia 2015;47:832–8.Google Scholar
Li, K, Rodriguez, D, Gabrielsen, JS, Centola, GM, Tanrikut, C. Sperm cryopreservation of transgender individuals: trends and findings in the past decade. Andrology 2018;6:860–4.Google Scholar
Marsh, C, Gray, M, Nangia, A, Gay, J, Roby, KF. Low total motile sperm in transgender women seeking hormone therapy. J Assist Reprod Genet 2019;36:1639–48.Google Scholar
Adeleye, AJ, Kao, CN, Mok-Lin, E, Smith, JF. Semen parameters among transgender women with a history of hormonal treatment. Urology 2020;124:136–41.Google Scholar
Alford, A, Kim, N, Bodie, J, Pariser, J. Successful ejaculatory sperm cryopreservation after cessation of long-term estrogen therapy in a transgender female. Urology 2020;136:e48–50.Google Scholar
Schulze, C. Response of the human testis to long-term estrogen treatment: morphology of Sertoli cells, Leydig cells and spermatogonial stem cells. Cell Tissue Res 251:31–43.Google Scholar
Rajfer, J, Heber, DM. Testicular histology following chronic gonadotropin-releasing hormone agonist treatment. Fertil Steril 1984;42:765–71.Google Scholar
Smith, JA Jr. Testicular histology after prolonged treatment with a gonadotropin-releasing hormone analogue. J Urol 133:612–14.Google Scholar
Giberti, C, Martorana, G, Truini, M, Franceschini, R, Rolandi, E, Giuliani, L. Hormonal pattern and testicular histology in patients with prostatic cancer after long-term treatment with a gonadotropin-releasing hormone agonist analogue. Eur Urol 1988:125–7.Google Scholar
Schneider, F, Wistuba, J, Zitzmann, M, et al. Testicular functions and clinical characterization of patients with cender dysphoria (GD) undergoing sex reassignment surgery (SRS). J Sex Med 2015;12:2190–200.Google Scholar
Lao, M, Honig, S. Evaluation of testicular sperm extraction and testis histology in gender affirming surgery patients. J Urol 2018;199:e226.Google Scholar
Kent, MA, Winoker, JS, Grotas, AB. Effects of feminizing hormones on sperm production and malignant changes: microscopic examination of post orchiectomy specimens in transwomen. Urology 2018;121:93–6.Google Scholar
Jiang, DD, Mason, M, Turner, KR, Dugi, DD, Hedges, JC, Hecht, SL. Effects of estrogen on spermatogenesis in transgender women. Urology 2019;132:117–22.Google Scholar
Picton, HM, Anderson, RA, Goossens, E, et al. A European perspective on testicular tissue cryoprervation for fertility preservation in prepubertal and adolescent boys. Hum Reprod 2015;30:2463–75.Google Scholar
Ma, HM, Chen, RM, Zhu, C, et al. Pubertal development timing in urban Chinese boys. Int J Andol 2011;34:435–45.Google Scholar
Duadin, M, Walschaerts, M, Drouineaud, V, et al. Sperm cryopreservation in adolescent and young adults with cancer: results of French national sperm banking network (CECOS). Fertil Steril 2015;103:478–86.Google Scholar
Bertelooni, S, Ferdeghini, M, Menchini-Fabris, F, Saggese, G. Final height, gonadal function and bone mineral density of adolescent males with central precocious puberty after therapy with gonadotropin-releasing hormone analogues. Eur J Pediatr 2000;159:369–74.Google Scholar