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Chapter 17 - Vascular Endothelial Growth Factor Gene Therapy in the Management of Cardiovascular Problems in Pregnancy

from Section 4 - Cardiovascular Therapies

Published online by Cambridge University Press:  28 April 2018

Christoph Lees
Affiliation:
Imperial College London
Wilfried Gyselaers
Affiliation:
Hasselt Universiteit, Belgium
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Maternal Hemodynamics , pp. 171 - 180
Publisher: Cambridge University Press
Print publication year: 2018

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References

Charnock-Jones, DS, Kaufmann, P, Mayhew, TM. Aspects of human fetoplacental vasculogenesis and angiogenesis. I. Molecular regulation. Placenta 2004;25:103–13.Google ScholarPubMed
Konje, JC, Howarth, ES, Kaufmann, P, Taylor, DJ. Longitudinal quantification of uterine artery blood volume flow changes during gestation in pregnancies complicated by intrauterine growth restriction. BJOG. 2003;110(3):301–5.CrossRefGoogle ScholarPubMed
Ferrara, N, Gerber, HP, Le Couter, J. The biology of VEGF and its receptors. Nat Med 2003;9:669–76.CrossRefGoogle ScholarPubMed
Holmes, DI, Zachary, I. The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease. Genome Biol. 2005;6:209.Google Scholar
Zachary, I. Neuropilins: role in signalling, angiogenesis and disease. Chem Immunol Allergy. 2014;99: 3770.CrossRefGoogle ScholarPubMed
Binder, NK, Evans, J, Gardner, DK, Salamonsen, LA, Hannan, NJ. Endometrial signals improve embryo outcome: functional role of vascular endothelial growth factor isoforms on embryo development and implantation in mice. Hum Reprod. 2014;29(10):2278–86.CrossRefGoogle ScholarPubMed
Carmeliet, P, Ferreira, V, Breier, G, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996;380:435–9.CrossRefGoogle ScholarPubMed
Kaufmann, P, Mayhew, TM, Charnock-Jones, DS. Aspects of human fetoplacental vasculogenesis and angiogenesis. II. Changes during normal pregnancy. Placenta. 2004;25(2–3):114–26.CrossRefGoogle ScholarPubMed
Andraweera, PH, Dekker, GA, Roberts, CT. The vascular endothelial growth factor family in adverse pregnancy outcomes. Hum Reprod Update. 2012;18(4):436–57.Google Scholar
Romero, R, Nien, JKEspinoza, J, et al. A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonateJ. Matern. Fetal Neonatal Med2008;21:923.Google Scholar
Jain, RK. Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia. Cancer Cell. 2014;26(5):605–22.Google Scholar
Martin, DF, Maguire, MG. Treatment choice for diabetic macular edema. N Engl J Med. 2015 Mar 26;372(13):1260–1.Google Scholar
Baumgartner, I, Pieczek, A, Manor, O, et al. Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation. 1998;97(12):1114–23.CrossRefGoogle ScholarPubMed
Sanada, F, Taniyama, Y, Kanbara, Y, et al. Gene therapy in peripheral artery disease. Expert Opin Biol Ther 2015;15(3):381–90.CrossRefGoogle ScholarPubMed
Banai, S, Shweiki, D, Pinson, A, et al. Upregulation of vascular endothelial growth factor expression induced by myocardial ischaemia: implications for coronary angiogenesis. Cardiovasc Res 1994;28:1176–9.CrossRefGoogle ScholarPubMed
Henry, TD, Annex, BH, McKendall, GR, et al. VIVA Investigators The VIVA trial: vascular endothelial growth factor in ischemia for vascular angiogenesis. Circulation 2003;107:1359–65Google Scholar
Rubanyi, GM. Identifying and overcoming obstacles in angiogenic gene therapy for myocardial ischemia. J Cardiovasc Pharmacol 2014;64 (2):109–19.CrossRefGoogle ScholarPubMed
Spencer, RN, Carr, DJ, David, AL. Treatment of poor placentation and the prevention of associated adverse outcomes – what does the future hold? Prenat Diagn, 2014;34:677–84.Google Scholar
Baschat, AA, Cosmi, E, Bilardo, CM, et al. Predictors of neonatal outcome in early-onset placental dysfunction. Obstet Gynecol. 2007;109(2 Pt 1):253–61.CrossRefGoogle ScholarPubMed
Spencer, R, Carr, DJ, David, A. Gene therapy for obstetric conditions. Fetal Matern Med Rev, 2015;25(3–4):147–77.Google Scholar
David, AL, Torondel, B, Zachary, I, et al. Local delivery of VEGF adenovirus to the uterine artery increases vasorelaxation and uterine blood flow in the pregnant sheep. Gene Ther 2008;15:1344–50.Google Scholar
Mehta, V, Abi-Nader, KN, Shangaris, P, et al. Local over-expression of VEGF-DΔNΔC in the uterine arteries of pregnant sheep results in long-term changes in uterine artery contractility and angiogenesis. PLoS One, 2014;99.(6):e100021CrossRefGoogle Scholar
Mehta, V, Abi-Nader, K, Peebles, D, et al. Long-term increase in uterine blood flow is achieved by local overexpression of VEGF-A(165) in the uterine arteries of pregnant sheep. Gene Ther 2011;September: 8696.Google Scholar
Wallace, JM, Luther, JS, Milne, JS, et al. Nutritional modulation of adolescent pregnancy outcome – a review. Placenta. 2006; 27 Suppl A: S618.CrossRefGoogle ScholarPubMed
Carr, DJ, Aitken, RP, Milne, JS, David, AL, Wallace, JM. Ultrasonographic assessment of growth and estimation of birthweight in late gestation fetal sheep. Ultrasound Med Biol. 2011; 37(10):1588–95.Google Scholar
Smith, GC, Smith, MF, McNay, MB, Fleming, JE. The relation between fetal abdominal circumference and birthweight: findings in 3512 pregnancies. BJOG. 1997; 104(2):186–90.CrossRefGoogle ScholarPubMed
Carr, DJ, Wallace, JM, Aitken, RP, et al. Uteroplacental adenovirus vascular endothelial growth factor gene therapy increases fetal growth velocity in growth-restricted sheep pregnancies. Hum. Gene Ther 2014;25:375–84.Google Scholar
Carr, DJ, Wallace, JM, Aitken, R, et al. Peri- and postnatal effects of prenatal adenoviral VEGF gene therapy in growth-restricted sheep. Biol. Reprod 2016;9: 142.Google Scholar
Swanson, AM, Mehta, V, Ofir, K, et al. The use of ultrasound to assess fetal growth in a guinea pig model of fetal growth restriction. Lab. Anim. Apr 26. pii: 0023677216637506Google Scholar
Carter, AM. Animal models of human placentation–a review. Placenta. 2007;28 Suppl A:S417.CrossRefGoogle ScholarPubMed
Swanson, A, Rossi, C, Ofir, K, et al. Maternal uterine artery gene therapy with Ad.VEGF-A165 increases weight at term in a guinea pig model of fetal growth restriction. Hum Gene Ther 2015;26:A14.Google Scholar
Feldman, LJ, Pastore, CJ, Aubailly, N., et al. Improved efficiency of arterial gene transfer by use of poloxamer 407 as a vehicle for adenoviral vectors. Gene Ther 1997;4(3):189–98.CrossRefGoogle ScholarPubMed
Pelage, JP, Dref, O, Le Mateo, J, et al. Life-threatening primary postpartum hemorrhage: treatment with emergency selective arterial embolization. Radiology 1998;208:359–62.Google Scholar
Angstmann, T, Gard, G, Harrington, T, Ward, E, Thomson, A, Giles, W. Surgical management of placenta accreta: a cohort series and suggested approach. Am J Obstet Gynecol 2010;202(1):38.e1–9.CrossRefGoogle ScholarPubMed
Sheppard, MK, David, AL, Spencer, R, Ashcroft, R. Consortium, E, Ethics and ethical evaluation of a proposed clinical trial with maternal uterine artery vascular endothelial growth factor gene therapy to treat severe early onset fetal growth restriction in pregnant. Hum. Gene Ther 2014;25:A98.Google Scholar
Senger, DR, Asch, BB, Smith, BD, Perruzzi, CA, Dvorak, HF. A secreted phosphoprotein marker for neoplastic transformation of both epithelial and fibroblastic cells. Nature. 1983 Apr 21;302(5910):714–5.CrossRefGoogle ScholarPubMed

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