Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-7479d7b7d-t6hkb Total loading time: 0 Render date: 2024-07-11T05:25:32.082Z Has data issue: false hasContentIssue false

Chapter 14 - The Use of LH Supplements to Improve the Response to Ovarian Stimulation

from Section 3 - Supplements to Improve Oocytes

Published online by Cambridge University Press:  04 January 2019

By
Rachael Rodgers  and
William Ledger
Edited by
Gabor Kovacs ,
Anthony Rutherford  and
David K. Gardner
Gabor Kovacs
Affiliation:
Monash University, Victoria
Anthony Rutherford
Affiliation:
University of Leeds
David K. Gardner
Affiliation:
University of Melbourne
Get access

Summary

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Chapter
Information
How to Prepare the Egg and Embryo to Maximize IVF Success , pp. 167 - 181
Publisher: Cambridge University Press
Print publication year: 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Choi, J, Smitz, J. Luteinizing hormone and human chorionic gonadotropin: origins of difference. Molecular and Cellular Endocrinology 2014; 383: 203–213.Google Scholar
Talmadge, K, Vamvakopoulos, NC, Fiddes, JC. Evolution of the genes for the b subunits of human chorionic gonadotropin and luteinizing hormone. Nature 1984; 307: 37–40.CrossRefGoogle Scholar
Menon, KMJ, Menon, B. Structure, function and regulation of gonadotropin receptors – a perspective. Molecular and Cellular Endocrinology 2012; 356: 88–97.Google Scholar
Fevold, HL. Synergism of the follicle stimulating and luteinizing hormones in producing estrogen secretion. Endocrinology 1941; 28: 33–36.Google Scholar
Garzo, VG, Dorrington, JH. Aromatase activity in human granulosa cells during follicular development and the modulation by follicle-stimulating hormone and insulin. American Journal of Obstetrics & Gynecology 1984; 148: 657–662.Google Scholar
Steinkampf, MP, Mendelson, CR, Simpson, ER. Regulation by follicle-stimulating hormone of the synthesis of aromatase cytochrome P-450 in human granulosa cells. Molecular Endocrinology 1987; 1: 465–471.CrossRefGoogle ScholarPubMed
Cole, LA. Biological functions of hCG and hCG-related molecules. Reproductive Biology and Endocrinology 2010; 8: 102.Google Scholar
Casarini, L, Lispi, M, Longobardi, S et al. LH and hCG action on the same receptor results in quantitatively and qualitatively different intracellular signalling. PLoS One 2012; 7(10): e46682, 1–15.Google Scholar
Humaidan, P, Bungum, L, Bungum, M, Andersen, CY. Ovarian response and pregnancy outcome related mid-follicular LH levels in women undergoing assisted reproduction with GnRH agonist down-regulation and recombinant FSH stimulation. Human Reproduction 2002; 17: 2016–2021.CrossRefGoogle ScholarPubMed
Westergaard, LG, Laursen, SB, Andersen, CY. Increased risk of early pregnancy loss by profound suppression of luteinizing hormone during ovarian stimulation in normogonadotropic women undergoing assisted reproduction. Human Reproduction 2000; 15: 1003–1008.Google Scholar
Fleming, R, Rehka, P, Deshpande, N et al. Suppression of LH during ovarian stimulation: effects differ in cycles stimulated with purified urinary FSH and recombinant FSH. Human Reproduction 2000; 15: 1440–1445.Google Scholar
Esteves, SC, Alviggi, C. The role of LH in controlled ovarian stimulation. In Ghuman, S (ed), Principles and Practice of Controlled Ovarian Stimulation in ART, 2015; Springer.Google Scholar
Shoham, Z, Smith, H, Teko, T et al. Recombinant LH (lutropin alfa) for the treatment of hypogonadotropic women with profound LH deficiency: a randomized, double-blind, placebo-controlled, proof-of-efficacy study. Clinical Endocrinology 2008; 69: 471–478.Google Scholar
Ganirelix Dose-finding Study Group. A double-blind, randomized, dose-finding study to assess the efficacy of the gonadotropin-releasing hormone antagonist ganirelix (Org 37462) to prevent premature luteinizing hormone surges in women undergoing ovarian stimulation with recombinant follicle stimulating hormone (Puregon). Human Reproduction 1998; 13: 3023–3031.Google Scholar
Chappel, SC, Howles, C. Reevaluation of the roles of luteinizing hormone and follicle-stimulating hormone in the ovulatory process. Human Reproduction 1991; 6:1206–1212.CrossRefGoogle ScholarPubMed
Doody, K, Devroey, P, Gordon, K, Witjes, H, Mannaerts, B. LH concentrations do not correlate with pregnancy in rFSH/GnRH antagonist cycles. Reproductive BioMedicine Online 2010; 20:565–567.Google Scholar
Baruffi, RLR, Mauri, AL, Petersen, CG et al. Recombinant LH supplementation to recombinant FSH during induced ovarian stimulation in the GnRH-antagonist protocol: a meta-analysis. RBM Online 2007; 14: 14–25.Google Scholar
Kolibianakis, EM, Kalogeropoulou, L, Griesinger, G et al. Among patients treated with FSH and GnRH analogues for in vitro fertilization, is the addition of recombinant LH associated with the probability of live birth? A systematic review and meta-analysis. Human Reproduction Update 2007; 13: 445–452.Google Scholar
Mochtar, MH, Van der, Veen, Ziech, M, van Wely, M. Recombinant luteinizing hormone (rLH) for controlled ovarian hyperstimulation in assisted reproductive cycles. Cochrane Database of Systematic Reviews 2007; 18(2): CD005070.Google Scholar
Oliveira, JBA, Mauri, AL, Petersen, CG et al. Recombinant luteinizing hormone supplementation to recombinant follicle-stimulation hormone during induced ovarian stimulation in the GnRH-agonist protocol: a meta-analysis. Journal of Assisted Reproduction and Genetics 2007; 24: 67–75.Google Scholar
Sills, ES, Levy, DP, Moomjy, M, McGee, M, Rosenwaks, Z. A prospective, randomized comparison of ovulation induction using highly purified follicle stimulating hormone alone and with recombinant human luteinizing hormone in in-vitro fertilization. Human Reproduction 1999; 14: 2230–2235.Google Scholar
Tarlatzis, B, Tavmergen, E, Szamatowicz, M et al. The use of recombinant human LH (lutropin alfa) in the late stimulation phase of assisted reproduction cycles: a double-blind, randomized, prospective study. Human Reproduction 2006; 21: 90–94.CrossRefGoogle ScholarPubMed
Balasch, J, Miro, F, Burzaco, I et al. The role of luteinizing hormone in human follicle development and oocyte fertility: evidence from in-vitro fertilization in a woman with long-standing hypogonadotropic hypogonadism and using recombinant human follicle stimulating hormone. Human Reproduction 1995; 10: 1678–1683.Google Scholar
European Recombinant Human LH Study Group. Recombinant human luteinizing hormone (LH) to support recombinant human follicle-stimulating hormone (FSH)-induced follicular development in LH- and FSH-deficient anovulatory women: a dose finding study. Journal of Clinical Endocrinology and Metabolism 1998; 83: 1507–1514.Google Scholar
Polyzos, NP, Devroey, P. A systematic review of randomized trials for the treatment of poor ovarian responders: is there any light at the end of the tunnel? Fertility and Sterility 2011; 96: 1058–1061.Google Scholar
Ferrareti, AP, La Marca, A, Fauser, BCJM et al. ESHRE consensus on the definition of “poor response” to ovarian stimulation for in vitro fertilization: the Bologna criteria. Human Reproduction 2011; 26(7): 1616–1624.Google Scholar
Papathanasiou, A. Implementing the ESHRE “poor responder” criteria in research studies: methodological implications. Human Reproduction 2014; 29: 1835–1838.Google Scholar
Musters, AM, van Wely, M, Mastenbroek, S et al. The effect of recombinant LH on embryo quality: a randomized controlled trial in women with poor ovarian reserve. Human Reproduction 2012; 27: 244–250.CrossRefGoogle ScholarPubMed
Bosch, E, Labarta, E, Crespo, J et al. Impact of luteinizing hormone administration on gonadotropin-releasing hormone antagonist cycles: an age-adjusted analysis. Fertility and Sterility 2011; 95: 1031–1036.CrossRefGoogle ScholarPubMed
De Placido, G, Alviggi, C, Perino, A et al. Recombinant human LH supplementation versus recombinant human FSH (rFSH) step-up protocol during controlled ovarian stimulation in normogonadotropic women with initial inadequate ovarian response to rFSH. A multicentre, prospective, randomized controlled trial. Human Reproduction 2005; 20: 390–396.Google Scholar
Berkkanoglu, M, Isikoglu, M, Aydin, D, Ozgur, K. Clinical effects of ovulation induction with recombinant follicle-stimulating hormone supplemented with recombinant luteinizing hormone or low-dose recombinant human chorionic gonadotropin in the midfollicular phase in microdose cycles in poor responders. Fertility and Sterility 2007; 88: 665–669.Google Scholar
Barrenetxea, G, Agirregoikoa, JA, Jimenez, MR et al. Ovarian response and pregnancy outcome in poor-responder women: a randomized controlled trial on the effect of luteinizing hormone supplementation on in vitro fertilization cycles. Fertility and Sterility 2008; 89: 546–553.Google Scholar
Humaidan, P, Chin, W, Rogoff, D et al. Efficacy and safety of follitropin alfa/lutropin alfa in ART: a randomized controlled trial in poor ovarian responders. Human Reproduction 2017; 32: 544–555.Google Scholar
Lehert, P, Kolibianakis, EM, Venetis, C et al. Recombinant human follicle-stimulating hormone (rhFSH) plus recombinant luteinizing hormone versus r-hFSH alone for ovarian stimulation during assisted reproductive technology: systematic review and meta-analysis. Reproductive Biology and Endocrinology 2014; 12: 17.Google Scholar
Fan, W, Li, S, Chen, Q et al. Recombinant luteinizing hormone supplementation in poor responders undergoing IVF: a systematic review and meta-analysis. Gynecological Endocrinology 2013; 29(4): 278–284.Google Scholar
Vuong, TNL, Phung, HT, Ho, MT. Recombinant follicle-stimulating hormone and recombinant luteinizing hormone versus recombinant follicle-stimulating hormone alone during GnRH antagonist ovarian stimulation in patients aged >=35 years: a randomized controlled trial. Human Reproduction 2015; 30: 1188–1195.Google Scholar
Behre, HM, Howles, CM, Longobardi, S. Randomized trial comparing luteinizing hormone supplementation timing strategies in older women undergoing ovarian stimulation. Reproductive BioMedicine Online 2015; 31: 339–346.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×