Following the birth of a depressed newborn, the infant's caretakers are involved in providing appropriate resuscitative techniques, stabilizing the infant's biochemical and physiological abnormalities, and evaluating the infant's response to these measures. The caretakers must also ascertain the cause of the infant's depression, attempt to determine when the event or events leading to the depression occurred, and develop a plan for follow-up evaluation and treatment that will be required. The determination of causation and timing not only has medical–legal implications, but is becoming extremely important in order to evaluate the types of therapy that may be utilized to mitigate the effects of a hypoxic–ischemic event. If the infant had suffered significant damage days or weeks prior to birth, then these rescue forms of therapy will have little, if any, beneficial effect on the infant's eventual outcome. In many situations, this determination is very difficult to make as there may be a myriad of events that could have occurred prior to the time of birth, and overlapping of significant problems makes this exercise an almost impossible task at times.

When an acute or sentinel event has taken place, such as a readily recognized prolapsed cord, an abruptio placentae, a ruptured uterus, or a disorder leading to acute and profound blood loss in the fetus, the timing of the event can be ascertained with a reasonable degree of accuracy.