Book contents
- Frontmatter
- Contents
- List of contributors
- Preface: Focus on the serotonin transporter
- 1 Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake
- 2 Cellular and molecular alterations in animal models of serotonin transporter disruption: a comparison between developmental and adult stages
- 3 Developmental roles for the serotonin transporter
- 4 SERT models of emotional dysregulation
- 5 The serotonin transporter and animal models of depression
- 6 The serotonin transporter knock-out rat: a review
- 7 Wistar–Zagreb 5HT rats: a rodent model with constitutional upregulation/downregulation of serotonin transporter
- 8 The role of the serotonin transporter in reward mechanisms
- 9 Modeling SERT × BDNF interactions in brain disorders: single BDNF gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities in serotonin transporter knock-out mice
- 10 Primate models in serotonin transporter research
- 11 The role of serotonin transporter in modeling psychiatric disorders: focus on depression, emotion regulation, and the social brain
- Index
- Plate section
- References
4 - SERT models of emotional dysregulation
Published online by Cambridge University Press: 06 July 2010
- Frontmatter
- Contents
- List of contributors
- Preface: Focus on the serotonin transporter
- 1 Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake
- 2 Cellular and molecular alterations in animal models of serotonin transporter disruption: a comparison between developmental and adult stages
- 3 Developmental roles for the serotonin transporter
- 4 SERT models of emotional dysregulation
- 5 The serotonin transporter and animal models of depression
- 6 The serotonin transporter knock-out rat: a review
- 7 Wistar–Zagreb 5HT rats: a rodent model with constitutional upregulation/downregulation of serotonin transporter
- 8 The role of the serotonin transporter in reward mechanisms
- 9 Modeling SERT × BDNF interactions in brain disorders: single BDNF gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities in serotonin transporter knock-out mice
- 10 Primate models in serotonin transporter research
- 11 The role of serotonin transporter in modeling psychiatric disorders: focus on depression, emotion regulation, and the social brain
- Index
- Plate section
- References
Summary
ABSTRACT
The serotonin system plays a key modulatory role in central nervous system processes that appear to be dysregulated in psychiatric disorders. Specifically, the serotonin transporter (SERT) is thought to be critical to many aspects of emotional dysregulation and has been a successful target for medications that treat several psychiatric disorders. Here, we narrowly focused on two psychiatric conditions; anxiety and depression, for which mice with SERT genetic manipulations have provided insight. Specifically, we suggest that dissecting syndromes according to a trait and state perspective may help us understand the complex and at times contradictory rodent results. The most compelling reason for this approach is provided by human studies, in which increased trait-neuroticism and stress-mediated vulnerability to develop depression were reported for subjects carrying the 5-HTTLPR s/s allele of the SERT gene, and thus placing the contribution of SERT to mood disorders in a gene × environment and trait/state context. Accordingly, current behavioral results in SERT knock-out (KO) mice are consistent with both increased trait and state anxiety-like behaviors, while evidence in support of a trait-based model of depression in SERT KO mice are inconsistent and mostly based on tests with limited relevance to human depression. However, comorbid symptoms associated with a wider definition of depression, such as altered gastrointestinal functions, lower pain threshold, and greater sensitivity to stress, have been reported in SERT KO mice, suggesting the presence of a pro-depressive state resulting from low SERT.
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- Chapter
- Information
- Experimental Models in Serotonin Transporter Research , pp. 105 - 134Publisher: Cambridge University PressPrint publication year: 2010
References
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