The Milky Way is largely empty. Stars are separated by some 2 pc in the solar neighborhood (ρ⋆ = 6 × 10−2 pc−3). If we take our Solar System as a measure, with a heliosphere radius of ≃235 AU, stars and their associated planetary systems fill about 3 × 10−10 of the available space. This book deals with what is in between these stars: the interstellar medium (ISM). The ISM is filled with a tenuous hydrogen and helium gas and a sprinkling of heavier atoms. These elements can be neutral, ionized, or in molecular form and in the gas phase or in the solid state. This gas and dust is visibly present in a variety of distinct objects: HII regions, reflection nebulae, dark clouds, and supernova remnants. In a more general sense, the gas is organized in phases – cold molecular clouds, cool HI clouds, warm intercloud gas, and hot coronal gas – of which those objects are highly visible manifestations. This gas and dust is heated by stellar photons, originating from many stars (the so-called average interstellar radiation field), cosmic rays (energetic [∼GeV] protons), and X-rays (emitted by local, galactic, and extragalactic hot gas). This gas and dust cools through a variety of line and continuum processes and the spectrum will depend on the local physical conditions. Surveys in different wavelength regions therefore probe different components of the ISM. This first chapter presents an inventory of the ISM with an emphasis on prominent objects in the ISM and the global structure of the ISM.