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Modifiable health behaviours, including suboptimal dietary patterns, contribute to the global burden of disease. Messaging to raise awareness about health and nutrition behaviours is an important first step toward behaviour change and promotion of healthy dietary patterns. The aim of this rapid review was to systematically identify best practice recommendations and evidence for the development and characteristics of persuasive health and nutrition messages for awareness raising among adults. Academic reviews and grey literature reports published in English after 2010 that focused on the development or characteristics of general health or nutrition-specific messaging for awareness raising were eligible. MEDLINE Complete, CINHAL, Global Health, Embase and websites of public health organisations were searched between April-July 2024. Data was synthesised narratively. From 12,507 records, 31 were included (27 reviews, 4 reports). There was consistent support for an audience-centred approach to messaging, including audience segmentation, message tailoring and testing with target audiences. It was recommended that messages be disseminated through multiple channels, including mass and social media to facilitate repeat exposure. Message characteristics including use of narratives, simple language, keeping messages short, conveying the general gist rather than detailed information and utilising imagery were considered best practice for persuasive messaging. Nutrition messages that are audience-centred, tailored, thoroughly tested and incorporate elements such as narratives, imagery and simple language are likely to be accepted and persuasive among adults. Findings can be used to inform effective nutrition messaging for awareness raising in research and nutrition promotion settings.
We consider the problem of a cylindrical (quasi-two-dimensional) droplet impacting on a hard surface. Cylindrical droplet impact can be engineered in the laboratory, and a theoretical model of the system can also be used to shed light on various complex experiments involving the impact of liquid sheets. We formulate a rim-lamella model for the droplet-impact problem. Using Gronwall’s inequality applied to the model, we establish theoretical bounds for the maximum spreading radius $\mathcal{R}_{\textit{max}}$ in droplet impact, specifically $k_1 {\textit{Re}}^{1/3}-k_2(1-\cos \vartheta _a)^{1/2}({\textit{Re}}/{\textit{We}})^{1/2}\leq \mathcal{R}_{\textit{max}}/R_0\leq k_1{\textit{Re}}^{1/3}$, valid for ${\textit{Re}}$ and ${\textit{We}}$ sufficiently large. Here, ${\textit{Re}}$ and ${\textit{We}}$ are the Reynolds and Weber number based on the droplet’s pre-impact velocity and radius $R_0$, $\vartheta _a$ is the advancing contact angle (assumed constant in our simplified analysis) and $k_1$ and $k_2$ are constants. We perform several campaigns of simulations using the volume of fluid method to model the droplet impact, and we find that the simulation results fall within the theoretical bounds.
There is now an abundance of literature pointing to the relationship between the escalating global impacts of climate change and the adverse effects of irreversible ecological destruction on the emotional worlds of children and young people. Contextualised to Manitoba, Canada, this article is positioned as a call for a more relationally accountable and response-able engagement with climate change and (child/youth) emotions, supporting curricular and pedagogical enactments in (western) education to grapple more ethically with social and ecological threats and injustices of these times. Through an anticolonial and posthumanist self-study in collaboration with a middle-years classroom, this article experiments with climate anxiety as anticolonial activism. Such a move seeks to generate different types of relations with Indigenous peoples, Land, and multispecies kin; and (re)imagine curricular and pedagogical enactments that usher open-ended, ambiguous, and indefinite engagement with the emotional politics of settler-colonialism.
Outpatient parenteral antimicrobial therapy (OPAT) is a mainstay of clinical infectious diseases practice, and OPAT-related publications continue to be prominent in journals. The objective of this article is to summarize ten clinically important OPAT-related publications from 2024.
Design:
Narrative review.
Methods:
Eighty-one articles were found in a literature search, and 56 met inclusion criteria. A survey containing 25 articles was sent to an email listserv of clinicians with OPAT experience.
Results:
This article summarizes the top 10 OPAT articles published in 2024, based on those survey results.
Conclusions:
Common themes from the top 10 OPAT articles published in 2024 included OPAT clinician workload, patient perspectives of OPAT, tools for OPAT work, and dalbavancin use.
Psychosis is a severe mental health condition that often remains untreated in low- and middle-income countries (LMICs), leading to significant health and societal costs. Early intervention in psychosis (EIP) reduces hospitalisation rates, improves treatment adherence, and preserves functional abilities. However, challenges in LMICs, such as resource constraints, reliance on traditional healers, and limited mental health literacy, hinder effective care. Proposed strategies include developing context-specific guidelines, expanding access to care, addressing stigma, fostering community engagement, and investing in workforce training. Implementing EIP in LMICs is a crucial step toward reducing the treatment gap and improving long-term outcomes for affected individuals.
We described a 14-year-old boy who underwent catheter ablation for atrial tachycardia that had difficulty in creating the whole circuit of 3D map due to widely spread scar after repeated surgery for multivalvular heart disease. The classical atrial entrainment method was very effective in planning the catheter ablation for the invisible circuit of the atrial tachycardia.
Pulmonary valve or main pulmonary artery infective endocarditis is rare in children and is associated with high morbidity and mortality. Fungal infective endocarditis, most commonly caused by Candida species, is particularly aggressive and often requires a combination of antifungal therapy and surgical intervention. We report two infants who developed Candida endocarditis following pulmonary artery banding.
In the first case, a female infant developed persistent candidemia after pulmonary artery banding, with echocardiography revealing a mobile mass at the pulmonary bifurcation and computed tomography angiography demonstrating a mycotic pseudoaneurysm. Blood cultures confirmed Candida albicans. She underwent debanding and main pulmonary artery reconstruction, later requiring pacemaker implantation, and recovered without relapse. In the second case, a female infant presented with fever and candidaemia after pulmonary artery banding. Echocardiography identified a distal main pulmonary artery vegetation, and cultures grew Candida parapsilosis. She received amphotericin B–based induction therapy followed by fluconazole step-down after surgical source control, achieving clinical cure at follow-up.
These cases highlight the diagnostic and therapeutic challenges of Candida endocarditis after right-sided palliation. Early multimodality imaging, species-directed antifungal therapy, and timely surgery are critical to optimise outcomes in this rare but life-threatening complication.
Cognitive and behavioral symptoms of major depressive disorder (MDD) are linked to aberrant changes in the controllability of brain networks. However, previous studies examined network controllability using white matter tractography, neglecting the contributions of gray matter. We aimed to examine differences in the controllability of morphometric networks between patients with MDD and demographic-matched healthy controls and identify the associated neurobiological signatures.
Methods
Based on the structural and diffusion MRI data from two independent cohorts, we calculated the controllability of morphometric similarity networks for each participant. A generalized additive model was used to investigate the case–control differences in regional controllability and their cognitive and behavioral associations. We investigated the associations between imaging-derived controllability and neurotransmitters, brain metabolism, and gene transcription profiles using multivariate linear regression and partial least squares regression analyses.
Results
In both cohorts, depression-related abnormalities of morphometric network controllability were primarily located in the prefrontal, cingulate, and visual cortices, contributing to memory, sensation, and perception processes. These abnormalities in network controllability were spatially aligned with the distributions of serotonergic transmission pathways as well as with altered oxygen and glucose metabolism. In addition, these abnormalities spatially overlapped with differentially expressed genes enriched in annotations related to protein catabolism and mitochondria in neuronal cells and were disproportionately located on chromosome 22.
Conclusions
Collectively, neuroimaging evidence revealed aberrant morphometric network controllability underlying MDD-related cognitive and behavioral deficits, and the associated genetic and molecular signatures may help identify the neurobiological mechanisms underlying MDD and provide feasible therapeutic targets.
This article explores the ninth-century embassy to India purportedly sent by King Alfred, examining the evidence for this voyage, as well as its context, feasibility and credibility. It is argued that India, rather than Judea, was the intended destination of the alms dispatched to St Thomas and St Bartholomew in 883, given contemporary Anglo-Saxon knowledge of the lives of these two saints, and that such a destination would fit with the intellectual climate of Alfred’s court and be a suitable symbolic gesture. A journey to India would have a good context in the evidence for both a Syriac Christian community and a significant shrine of St Thomas in southern India that people from early medieval Europe might visit, with the likely location of the shrine being investigated. The archaeological and documentary evidence for the availability of early medieval trade routes to India is also analysed, as are the identities of Alfred’s emissaries.
Some of the most interesting insights into solar physics and space weather come from studying radio emissions associated with solar activity, which remain inherently unpredictable. Hence, a real-time triggering system is needed for solar observations with the versatile new-generation radio telescopes to efficiently capture these episodes of solar activity with the precious and limited solar observing time. We have developed such a system, Solar Triggered Observations of Radio bursts using MWA and Yamagawa (STORMY) for the Murchison Widefield Array (MWA), the precursor for the low frequency telescope of upcoming Square Kilometre Array Observatory (SKAO). It is based on near-real-time data from the Yamagawa solar spectrograph, located at a similar longitude to the MWA. We have devised, implemented, and tested algorithms to perform an effective denoising of the data to identify signatures of solar activity in the Yamagawa data in near real-time. End-to-end tests of triggered observations have been successfully carried out at the MWA. STORMY is operational at the MWA for the routine solar observations, a timely development in the view of the ongoing solar maximum. We present this new observing framework and discuss how it can enable efficient capturing of event-rich solar data with existing instruments, like the LOw Frequency ARray (LOFAR), Owens Valley Radio Observatory - Long Wavelength Array (OVRO-LWA) etc., and pave the way for triggered observing with the SKAO, especially the SKA-Low.
Elk Ridge was the largest pueblo in the northern Mimbres River Valley during the Classic Mimbres period. Data from the pueblo and surrounding sites indicate that it was the economic and ritual center of a larger community. Here, we use multiple lines of evidence—including survey data, ceramics, architecture, and faunal remains—to reconstruct the extent and structure of the Elk Ridge community. We see social interaction as the basis for community development, with (1) community members interacting to negotiate access to land, resources, and labor; and (2) communal rituals serving to reinforce cooperation and cohesion. The Elk Ridge community produced ceramics and raised turkeys that were traded to other Classic Mimbres communities, and these exchange networks created social ties between communities. Data from Elk Ridge also document interaction with non-Mimbres communities to the north, revealing a network of cultural interaction across the region. This study illustrates how landscape, location, kin relations, exchange networks, and ritual activities translate into a social community, similar to those we see throughout the US Southwest and elsewhere in the Neolithic world.
This single center retrospective observational study of serial plasma metagenomic next-generation sequencing testing shows that >95% of serial testing was without meaningful clinical impact. Only 5/173 cases were adjudicated as having significant clinical impact.
The Linear Pottery Culture site of Eilsleben, Germany, is the earliest potential fortified settlement in the borderland between the Early Neolithic world and Late Mesolithic populations. Building on extensive excavations and new fieldwork, an interdisciplinary programme investigates models of interaction between early farmers and Mesolithic hunter-gatherers in this region.
Irrigation can enhance yields and serve as a climate adaptation strategy. In the Southeastern U.S., where water resources are relatively abundant, irrigation has experienced significant growth. However, despite the region’s capacity for further expansion, irrigation adoption rates remain low. This study estimates the influence of peer effects on farmers’ decisions to adopt irrigation in South Carolina, using a unique parcel-level dataset on irrigation withdrawals. We find that adoption increases as farmers observe more peer adopting irrigation – social interactions – and as peers’ pumping increases, such as during drought periods, when the benefits of irrigation become more visible, facilitating social learning.
System components usually attain marginal lifetimes with stochastic dependence in the context of load-sharing reliability structures. This study deals with the load-sharing parallel systems of two components. We prove that two marginal lifetimes are positively quadrant dependent when component lifetimes have continuous probability distributions, and such a stochastic dependence is upgraded to the total positive of order 2 in the setting of component lifetimes having an exponential distribution. In addition, we discuss how these findings shed light on related results for the load-sharing Ross model, the conditional residual lifetime, and the conditional inactivity time.
The locus of nonsimple abelian varieties in the moduli space of principally polarized abelian varieties gives rise to Noether-Lefschetz cycles. We study their intersection theoretic properties using the tautological projection constructed in [4], and show that projection defines a homomorphism when restricted to cycles supported on that locus. Using Hecke correspondences and the pullback by Torelli we prove that $[\mathcal {A}_1 \times \mathcal A_{g-1}]$ is not tautological in the sense of [38] for $g=12$ and $g\geq 16$ even. We also explore the connections between Noether-Lefschetz cycles and the Gromov-Witten theory of a moving elliptic curve.
This article provides an account of Henry Sidgwick’s theory of representative government as presented in The Elements of Politics. It explains the relationship between many of Sidgwick’s substantive commitments on the matter to the growing conflict within British liberalism that resulted in the foundation of the Liberal Unionist Party, the breakaway faction of liberals committed to keeping Ireland in the British Empire and under the rule of the Westminster parliament. Despite important internal divisions within Liberal Unionism, this article argues that Sidgwick presents something close to a Liberal Unionist political theory. His theory of representative government attempted to reconcile two competing ideals of liberal governance: the desire for intellectual and economic elites to govern without being too constrained by partisanship or the public on the one hand, and, on the other, the belief that the liberal cause required mass support to be successful. Managing these competing ideals would prove to be the main challenge for the Liberal Unionist Party.