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The INECO Frontal Screening for the Evaluation of Executive Dysfunction in Cerebral Small Vessel Disease: Evidence from Quantitative MRI in a CADASIL Cohort from Colombia

Published online by Cambridge University Press:  03 June 2020

Dorothee Schoemaker ,
Yesica Zuluaga ,
Anand Viswanathan ,
Markus Shrimer ,
Heirangi Torrico-Teave ,
Lina Velilla ,
Carolina Ospina ,
Gloria Garcia Ospina ,
Francisco Lopera  and
Joseph F. Arboleda-Velasquez
...Show all authors
Dorothee Schoemaker
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
Yesica Zuluaga
Affiliation:
Grupo de Neurociencias, Universidad de Antioquia, Medellín 1226, Colombia
Anand Viswanathan
Affiliation:
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Markus Shrimer
Affiliation:
Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich 81377, Germany
Heirangi Torrico-Teave
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Lina Velilla
Affiliation:
Grupo de Neurociencias, Universidad de Antioquia, Medellín 1226, Colombia
Carolina Ospina
Affiliation:
Grupo de Neurociencias, Universidad de Antioquia, Medellín 1226, Colombia
Gloria Garcia Ospina
Affiliation:
Grupo de Neurociencias, Universidad de Antioquia, Medellín 1226, Colombia
Francisco Lopera
Affiliation:
Grupo de Neurociencias, Universidad de Antioquia, Medellín 1226, Colombia
Joseph F. Arboleda-Velasquez
Affiliation:
Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
Yakeel T. Quiroz*
Affiliation:
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA Grupo de Neurociencias, Universidad de Antioquia, Medellín 1226, Colombia Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
*
*Correspondence and reprint requests to: Yakeel T. Quiroz, PhD, Assistant Professor, Harvard Medical School, Departments of Psychiatry and Neurology, Massachusetts General Hospital, 39 1st Avenue, Suite 101, Boston, MA 02129, USA. E-mail: yquiroz@mgh.harvard.edu
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Abstract

Objectives:

Executive dysfunction is a predominant cognitive symptom in cerebral small vessel disease (SVD). The Institute of Cognitive Neurology Frontal Screening (IFS) is a well-validated screening tool allowing the rapid assessment of multiple components of executive function in Spanish-speaking individuals. In this study, we examined performance on the IFS in subjects with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), an inherited condition leading to the early onset of SVD. We further explored associations between performance on the IFS and magnetic resonance imaging (MRI) markers of SVD.

Methods:

We recruited 24 asymptomatic CADASIL subjects and 23 noncarriers from Colombia. All subjects underwent a research MRI and a neuropsychological evaluation, including the IFS. Structural MRI markers of SVD were quantified in each subject, together with an SVD Sum Score representing the overall burden of cerebrovascular alterations. General linear model, correlation, and receiver operating characteristic curve analyses were used to explore group differences on the IFS and relationships with MRI markers of SVD.

Results:

CADASIL subjects had a significantly reduced performance on the IFS Total Score. Performance on the IFS correlated with all quantified markers of SVD, except for brain atrophy and perivascular spaces enlargement. Finally, while the IFS Total Score was not able to accurately discriminate between carriers and noncarriers, it showed adequate sensitivity and specificity in detecting the presence of multiple MRI markers of SVD.

Conclusions:

These results suggest that the IFS may be a useful screening tool to assess executive function and disease severity in the context of SVD.

Keywords

Executive functionScreening toolQuantitative magnetic resonance imagingWhite matter hyperintensityLacunesCerebral microbleedsEnlarged perivascular spacesNOTCH3Spanish
Type
Regular Research
Information
Journal of the International Neuropsychological Society , Volume 26 , Issue 10 , November 2020 , pp. 1006 - 1018
Copyright
Copyright © INS. Published by Cambridge University Press, 2020

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