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Comparison of performance and intestinal morphology of broilers using step-down supplementation with a mannan-rich fraction versus bacitracin methylene disalicylate

Published online by Cambridge University Press:  17 June 2014

K.M. Brennan ,
M.A. Paul ,
R.S. Samuel ,
B. Lumpkins ,
J.L. Pierce ,
S.R. Collett  and
G.F. Mathis
K.M. Brennan*
Affiliation:
Alltech Inc., 3031 Catnip Hill Road, Nicholasville, KY 40356
M.A. Paul
Affiliation:
Alltech Inc., 3031 Catnip Hill Road, Nicholasville, KY 40356
R.S. Samuel
Affiliation:
Alltech Inc., 3031 Catnip Hill Road, Nicholasville, KY 40356
B. Lumpkins
Affiliation:
Southern Poultry Research, Inc., 96 Roguemore Road, Athens, GA 30607-2762
J.L. Pierce
Affiliation:
Alltech Inc., 3031 Catnip Hill Road, Nicholasville, KY 40356
S.R. Collett
Affiliation:
Poultry Diagnostic and Research Center, 953 College Station Road, Athens, GA 30602-4875
G.F. Mathis
Affiliation:
Southern Poultry Research, Inc., 96 Roguemore Road, Athens, GA 30607-2762
*
*Corresponding author: KBrennan@alltech.com
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Summary

Two experiments were conducted to compare effects of utilising step-down dosing of a mannan-rich fraction (MRF) of yeast cell wall or the antimicrobial growth promoter (AGP) bacitracin methylene disalicylate (BMD) when chicks were raised on built-up litter. Chicks were randomly assigned to one of three treatment groups (12 pen replicates; 50 birds per pen): basal diet (control) or basal diet plus MRF (Actigen™; Alltech Inc., Nicholasville, KY) or BMD (Alpharma Inc., Fort Lee, NJ). In experiment two, intestinal morphology and litter scores were determined on d 42. In experiment one, MRF and BMD increased BW gain at d 21 and d 42 compared with control (P ≤ 0.05) and d 42 BW was greater in BMD birds than controls (P ≤ 0.05). Adjusted FCRs were lower in MRF and BMD birds from d 0 to d 42 (P = 0.06). In experiment two, there was no effect of treatment on d 21 BW, but MRF and BMD improved adjusted FCR (P = 0.02) compared with control. By d 35, both MRF and BMD birds had greater BWs than controls (P = 0.04). At d 42, MRF-supplemented birds had greater BW than controls (P ≤ 0.05). D 35 and d 42 FCR improved with MRF or BMD compared with control (P ≤ 0.01). Litter conditions improved (P ≤ 0.05) when birds were fed diets with BMD and MRF compared with control-fed birds. Jejunal morphology, including villi height (P ≤ 0.05), villi height: crypt depth ratio (P ≤ 0.05), and goblet cell numbers (P ≤ 0.05) improved with MRF and BMD compared with control. Both MRF and BMD improved broiler performance, potentially related to the improvements observed in intestinal morphology. In conclusion, step-down supplementation with MRF may offer a potential alternative to AGP to improve performance in broilers raised in commercial settings.

Keywords

broilermannan-rich fractionActigengut morphology
Type
Original Article
Information
Journal of Applied Animal Nutrition , Volume 2 , 2013 , e12
Copyright
Copyright © Cambridge University Press and Journal of Applied Animal Nutrition Ltd. 2014 

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References

Agricultural Research Service. (1972) Antibiotics in animal and poultry feeds-a critical review of the research. (USDA, ARS, Washington, DC).Google Scholar
Baurhoo, B., Ferket, P.R. and Zhao, X. (2009) Effects of diets containing different concentrations of mannanoligosaccharide or antibiotics on growth performance, intestinal development, cecal and litter microbial populations, and carcass parameters of broilers. Poultry Science, 88: 2262–2272.Google Scholar
Baurhoo, B., Phillip, L. and Ruiz-Feria, C.A. (2007) Effects of purified lignin and mannan oligosaccharides on intestinal integrity and microbial populations in the ceca and litter of broiler chickens. Poultry Science, 86: 1070–1078.Google Scholar
Belley, A., Keller, K., Gottke, M. and Chadee, K. (1999) Intestinal mucins in colonisation and host defense against pathogens. American Journal of Tropical Medicine and Hygiene, 60: 10–15.Google Scholar
Brennan, K.M., Ao, T. and Pierce, J.L. (2010) Effects of Actigen™ supplementation on mRNA levels of mucin and markers of gut health in the jejunum of broiler chicks. Journal of Animal Science, 88 (E-Suppl 2): 650.Google Scholar
Brennan, K.M., Graugnard, D.E., Xiao, R., Spry, M.L., Pierce, J.L., Lumpkins, B. and Mathis, G.F. (2013) Comparison of gene expression profiles of the jejunum of broilers supplemented with a yeast cell wall-derived mannan oligosaccharide versus bacitracin methylene disalicylate. British Poultry Science, 54: 238–246.Google Scholar
Chee, S.H., Iji, P.A., Choct, M., Mikkelsen, L.L. and Kocher, A. (2010a) Characterisation and response of intestinal microflora and mucins to manno-oligosaccharide and antibiotic supplementation in broiler chickens. British Poultry Science, 51: 368–380.Google Scholar
Chee, S.H., Iji, P.A., Choct, M., Mikkelsen, L.L. and Kocher, A. (2010b) Functional interactions of manno-oligosaccharides with dietary threonine in chicken gastrointestinal tract. II. Mucosal development, mucin dynamics and nutrient utilisation. British Poultry Science, 51: 667–676.Google Scholar
Cobb-Vantress. (2002) Cobb 500 Breeder Management Guide. Blueprint for Success. Cobb-Vantress, Siloam Springs, AR.Google Scholar
Collett, S.R. (2012) Nutrition and wet litter problems in poultry. Animal Feed Science and Technology, 173: 65–75.Google Scholar
Cressman, M.D., Yu, Z., Nelson, M.C., Moeller, S.J., Lilbum, M.S. and Zerby, H.N. (2010) Interrelations between the microbiotas in the litter and in the intestines of commercial broiler chickens. Applied and Environmental Microbiology, 76: 6572–6582.Google Scholar
Davis, M.E., Maxwell, C.V., Brown, D.C., De Rodas, B.Z., Johnson, Z.B., Kegley, E.B., Hellwig, D.H. and Dvorak, R.A. (2002) Effect of dietary mannan oligosaccharides and (or) pharmacological additions of copper sulfate on growth performance and immunocompetence of weanling and growing/finishing pigs. Journal of Animal Science, 80: 2887–2894.Google Scholar
Dibner, J.J. and Richards, J.D. (2005) Antibiotic growth promoters in agriculture: history and mode of action. Poultry Science, 84: 634–643.Google Scholar
Dimitroglou, A., Merrifield, D.L., Moate, R., Davies, S.J., Spring, P., Sweetman, J. and Bradley, G. (2009) Dietary mannan oligosaccharide supplementation modulates intestinal microbial ecology and improves gut morphology of rainbow trout, Oncorhynchus mykiss (Walbaum). Journal of Animal Science, 87: 3226–3234.Google Scholar
Hooge, D.M. (2004) Meta-analysis of broiler chicken pen trials evaluating dietary mannan oligosaccharide. International Journal of Poultry Sciences, 3: 163–174.Google Scholar
Kim, G.B., Seo, Y.M., Kim, C.H. and Paik, I.K. (2011) Effect of dietary prebiotic supplementation on the performance, intestinal microflora, and immune response of broilers. Poultry Science, 90: 75–82.Google Scholar
Lea, H., Spring, P., Taylor-Pickard, J. and Burton, E. (2013) A natural carbohydrate fraction Aticgen™ from Saccharomyces cerevisiae cell wall: effects on goblet cells, gut morphology and performance of broiler chickens. Journal Applied Animal Nutrition, 1 e9; page 1 of 7.Google Scholar
Mack, D.R., Michail, S., Wei, S., McDougall, L. and Hollingsworth, M.A. (1999) Probiotics inhibit enteropathogenic E. coli adherence in vitro by inducing intestinal mucin gene expression. American Journal of Physiology, 276: G941–950.Google ScholarPubMed
Mathis, G.F.Lumpkins, B., Pierce, J.L. and Hooge, D.M. (2012) Effects of dietary antibiotics, Actigen® yeast cell wall derivative, or both on broiler chicken live performance in a fifty-two day pen trial on built-up litter. Journal of Poultry Science, 49: 313–318.Google Scholar
National Research Council. (1994) Nutrient Requirements of Poultry, 9th rev. ed. (Washington, DC, National AcademyPress).Google Scholar
Newman, K.E. (1994) Mannan-oligosaccharides: Natural polymers with significant impact on the gastrointestinal microflora and the immune system in Biotechnology in the Feed Industry, Proceedings of Alltech's 10th Annual Symposium (Nottingham University Press, Nottingham, UK)Google Scholar
Owens, B. and McCracken, K.J. (2007) A comparison of the effects of different yeast products and antibiotic on broiler performance. British Poultry Science, 48: 49–54.Google Scholar
Oyofo, B.A., Deloach, J.R., Corrier, D.E., Norman, J.O., Ziprin, R.L. and Mollenhauer, H.H. (1989a) Effect of carbohydrates on Salmonella typhimurium colonisation in broiler chickens. Avian Diseases, 33: 531–534.Google Scholar
Oyofo, B.A., Droleskey, R.E., Norman, J.O., Mollenhauser, H.H., Ziprin, R.L., Corrier, D.E. and Deloach, J.R. (1989b) Inhibition by mannose of in vitro colonisation of chicken small intestine by Salmonella typhimurium. Poultry Science, 68: 1351–1356.Google Scholar
Rosen, G.D. (2007) Holo-analysis of the efficacy of Bio-Mos in broiler nutrition. British Poultry Science, 48: 21–26.Google Scholar
Ruttanavut, J. and Yamauchi, K. (2010) Growth performance and histological alterations of intestinal villi in broilers fed dietary mixed minerals. Asian Journal of Animal Science, 4: 96–106.Google Scholar
Sajjan, S.U. and Forstner, J.F. (1990) Role of the putative “link” glycopeptide of intestinal mucin in binding of piliated Escherichia coli serotype O157:H7 strain CL-49. Infection and Immunity, 58: 868–873.Google Scholar
Shen, Y.B., Piao, X.S., Kim, S.W., Wang, L., Liu, P., Yoon, I. and Zhen, Y.G. (2009) Effects of yeast culture supplementation on growth performance, intestinal health, and immune response of nursery pigs. Journal of Animal Science, 87: 2614–2624.Google Scholar
Sims, M.D., Dawson, K.A., Newman, K.E., Spring, P. and Hoogell, D.M. (2004) Effects of dietary mannan oligosaccharide, bacitracin methylene disalicylate, or both on the live performance and intestinal microbiology of turkeys. Poultry Science, 83: 1148–1154.Google Scholar
Slavin, G., Sowter, C., Robertson, K., McDermott, S. and Paton, K. (1980) Measurement in jejunal biopsies by computer-aided microscopy. Journal of Clinical Pathology, 33: 254–261.Google Scholar
Smith, D.L., Johnson, J.A., Harris, A.D., Furuno, J.P., Perencevich, E.N. and Morris, J.G. Jr. (2003) Assessing risks for a pre-emergent pathogen: virginiamycin use and the emergence of streptogramin resistance in Enterococcus faecium. The Lancet Infectious Diseases, 3: 241–249.Google Scholar
Sohail, M.U., Hume, M.E., Byrd, J.A., Nisbet, D.J., Ijaz, A., Sohail, A.Shabbir, M.Z. and Rehman, H. (2012) Effect of supplementation of prebiotic mannan-oligosaccharides and probiotic mixture on growth performance of broilers subjected to chronic heat stress. Poultry Science, 91: 2235–2240.Google Scholar
Spring, P., Wenk, C., Dawson, K.A. and Newman, K.E. (2000) The effects of dietary mannaoligosaccharides on cecal parameters and the concentrations of enteric bacteria in the ceca of salmonella-challenged broiler chicks. Poultry Science, 79: 205–211Google Scholar
Torok, V.A., Hughes, R.J., Ophel-Keller, K., Ali, M. and Macalpine, R. (2009) Influence of different litter materials on cecal microbiota colonisation in broiler chickens. Poultry Science, 88: 2474–2481.Google Scholar
Tufarelli, V., Desantis, S., Zizza, S. and Laudadio, V. (2010) Performance, gut morphology and carcass characteristics of fattening rabbits as affected by particle size of pelleted diets. Archives of Animal Nutrition, 64: 373–382.Google Scholar
Van Beers-Schreurs, H.M., Nabuurs, M.J., Vellenga, L., Kalsbeek-Van Der Valk, H.J., Wensing, T. and Breukink, H.J. (1998)Weaning and the weanling diet influence the villous height and crypt depth in the small intestine of pigs and alter the concentrations of short-chain fatty acids in the large intestine and blood. Journal of Nutrition, 128: 947–953.Google Scholar
Van Nevel, C.J., Decuypere, J.A., Dieric, N.A. and Moll, K. (2005) Incorporation of galactomannans in the diet of newly weaned piglets: Effect on bacteriological and some morphological characteristics of the small intestine. Archives of Animal Nutrition, 59: 123–138.Google Scholar
Wang, J.X. and Peng, K.M. (2008) Developmental morphology of the small intestine of African ostrich chicks. Poultry Science, 87: 2629–2635.CrossRefGoogle ScholarPubMed
Yang, Y., Iji, P.A., Kocher, A., Mikkelsen, L.L. and Choct, M. (2008) Effects of dietary mannanoligosaccharide on growth performance, nutrient digestibility and gut development of broilers given different cereal-based diets. Journal of Animal Physiology and Animal Nutrition (Berl), 92: 650–659.Google Scholar
Zhao, P.Y., Jung, J.H. and Kim, I.H. (2012) Effect of mannan oligosaccharides and fructan on growth performance, nutrient digestibility, blood profile, and diarrhea score in weanling pigs. Journal of Animal Science, 90: 833–839.Google Scholar