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Chapter 2 - Red Cell Production

from Section 1 - The Normal Human Red Blood Cell

Published online by Cambridge University Press:  18 April 2018

Edward J. Benz, Jr.
Affiliation:
Dana Farber Cancer Institute
Nancy Berliner
Affiliation:
Brigham and Women's Hospital, Boston
Fred J. Schiffman
Affiliation:
Children's Hospital, Boston
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Summary

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Type
Chapter
Information
Anemia
Pathophysiology, Diagnosis, and Management
, pp. 14 - 18
Publisher: Cambridge University Press
Print publication year: 2017

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References

Schrier, SL. What does the spleen see? Blood. 2012 Jul 12; 120(2):242243.Google Scholar
Sieff, CA, Zon, LI. Anatomy and physiology of hematopoiesis. In: Orkin, SH, Nathan, DG, et al., eds. Nathan and Oski’s Hematology of Infancy and Childhood Edition 7. Philadelphia, Saunders Elsevier Press; 2009: 195273.Google Scholar
Adolfsson, J, Mansson, R, Buza-Vidas, N, et al. Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell. 2005 Apr 22; 121(2):295606.Google Scholar
Dore, LC and Crispino, JD. Transcription factor networks in erythroid cell and megakaryocyte development. Blood. 2011 Jul 14; 118(2):231239.CrossRefGoogle ScholarPubMed
Zhang, L, Sankaran, VG, Lodish, HF. MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment. Leukemia. 2012 Nov; 26(11):23102316.CrossRefGoogle ScholarPubMed
Hollanda, LM, Lima, CS, Cunha, AF, et al. An inherited mutation leading to production of only the short isoform of GATA-1 is associated with impaired erythropoiesis. Nat Genet. 2006; 38(7):807812.Google Scholar
Sankaran, VG, Ghazvinian, R, Do, R, et al. Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. J Clin Invest. 2012; 122(7):24392443.CrossRefGoogle ScholarPubMed
Welch, JJ, Watts, JA, Vakoc, CR, et al. Global regulation of erythroid gene expression by transcription factor GATA-1. Blood. 2004 Nov 15; 104(10):31363147.Google Scholar
Gregory, GD, Miccio, A, Bersenev, A, et al. FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment. Blood. 2010 Mar 18; 115(11):21562166.CrossRefGoogle ScholarPubMed
Jacobs, K, Shoemaker, C, Rudersdorf, R, et al. Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature. 1985 Feb 28–Mar 6; 313(6005):806810.CrossRefGoogle ScholarPubMed
Lin, FK, Suggs, S, Lin, CH, et al. Cloning and expression of the human erythropoietin gene. Proc Natl Acad Sci USA. 1985 Nov; 82(22):75807584.Google Scholar
Bunn, HF. Erythropoietin. Cold Spring Harb Perspect Med. 2013 Mar 1; 3:a011619.CrossRefGoogle ScholarPubMed
Franke, K, Gassman, M, Wielockx, B. Erythrocytosis: the HIF pathway in control. Blood. 2013 Aug 15; 122(7):11221128.CrossRefGoogle ScholarPubMed
Flygare, J, Rayon, Estrada V, Shin, C, et al. HIF1alpha synergizes with glucocorticoids to promote BFU-E progenitor self-renewal. Blood. 2011 Mar 24; 117(12):34353444.Google Scholar
Palis, J. Primitive and definitive erythropoiesis in mammals. Front Physiol. 2014 Jan 28; 5:3. eCollection 2014.Google Scholar
Broxmeyer, HE. Erythropoietin: multiple targets, actions, and modifying influences for biological and clinical consideration. J Exp Med. 2013 Feb 11; 210(2):205208.CrossRefGoogle ScholarPubMed
Hu, J, Liu, J, Xue, F, et al. Isolation and functional characterization of human erythroblasts at distinct stages: implications for understanding of normal and disordered erythropoiesis in vivo. Blood. 2013 Apr 18; 121(16):32463253.CrossRefGoogle ScholarPubMed
Migliaccio, AR and Papayannopoulou, . Erythropoiesis and the normal red cell. In: Warrel, DA, Cox, TM, and Firth, JD, eds. Oxford Textbook of Medicine. Oxford: Oxford University Press; 2012.Google Scholar
Ganz, T. Hepcidin and iron regulation, 10 years later. Blood. 2011 Apr 28; 117(17):44254433.Google Scholar
Wilkinson, N, Pantapoulos, K. IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation. Blood. 2013 Aug 29; 122(9):16581668.CrossRefGoogle ScholarPubMed
Chen, JJ. Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias. Blood. 2007 Apr 1; 109(7):26932699.Google Scholar
Chasis, JA, Mohandas, N. Erythroblastic islands: niches for erythropoiesis. Blood. 2008 Aug 1; 112(3):470478.CrossRefGoogle ScholarPubMed
Ney, PA. Normal and disordered reticulocyte maturation. Curr Opin Hematol. 2011 May; 18(3):152157.CrossRefGoogle ScholarPubMed
Salomao, M, Zhang, X, Yang, Y, et al. Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane. Proc Natl Acad Aci USA. 2008 Jun 10; 105(23):80268031.Google Scholar

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