Book contents
- Frontmatter
- Contents
- List of Abbreviations
- Dedication
- Preface
- A Change in Posture
- Acid-Base
- Action Potentials
- Adrenal Cortex I
- Adrenal Cortex II – Clinical Disorders
- Adrenal Medulla
- Arterial Pressure
- Autonomic Nervous System (ANS)
- Carbon Dioxide Transport
- Cardiac Cycle
- Cardiac Output (CO)
- Cell Signalling
- Cerebrospinal Fluid (CSF) and Cerebral Blood Flow
- Colon
- Control of Ventilation
- Coronary Circulation
- Fetal Circulation
- Glomerular Filtration and Renal Clearance
- Immobilization
- Liver
- Mechanics of Breathing I – Ventilation
- Mechanics of Breathing II – Respiratory Cycle
- Mechanics of Breathing III – Compliance and Elastance
- Mechanics of Breathing IV – Airway Resistance
- Microcirculation I
- Microcirculation II
- Micturition
- Motor Control
- Muscle I – Skeletal and Smooth Muscle
- Muscle II – Cardiac Muscle
- Nutrition: Basic Concepts
- Pancreas I – Endocrine Functions
- Pancreas II – Exocrine Functions
- Potassium Balance
- Proximal Tubule and Loop of Henle
- Pulmonary Blood Flow
- Renal Blood Flow (RBF)
- Respiratory Function Tests
- Small Intestine
- Sodium Balance
- Sodium and Water Balance
- Starvation
- Stomach I
- Stomach II – Applied Physiology
- Swallowing
- Synapses I – The Neuromuscular Junction (NMJ)
- Synapses II – Muscarinic Pharmacology
- Synapses III – Nicotinic Pharmacology
- Thyroid Gland
- Valsalva Manoeuvre
- Venous Pressure
- Ventilation/Perfusion Relationships
Immobilization
Published online by Cambridge University Press: 06 January 2010
- Frontmatter
- Contents
- List of Abbreviations
- Dedication
- Preface
- A Change in Posture
- Acid-Base
- Action Potentials
- Adrenal Cortex I
- Adrenal Cortex II – Clinical Disorders
- Adrenal Medulla
- Arterial Pressure
- Autonomic Nervous System (ANS)
- Carbon Dioxide Transport
- Cardiac Cycle
- Cardiac Output (CO)
- Cell Signalling
- Cerebrospinal Fluid (CSF) and Cerebral Blood Flow
- Colon
- Control of Ventilation
- Coronary Circulation
- Fetal Circulation
- Glomerular Filtration and Renal Clearance
- Immobilization
- Liver
- Mechanics of Breathing I – Ventilation
- Mechanics of Breathing II – Respiratory Cycle
- Mechanics of Breathing III – Compliance and Elastance
- Mechanics of Breathing IV – Airway Resistance
- Microcirculation I
- Microcirculation II
- Micturition
- Motor Control
- Muscle I – Skeletal and Smooth Muscle
- Muscle II – Cardiac Muscle
- Nutrition: Basic Concepts
- Pancreas I – Endocrine Functions
- Pancreas II – Exocrine Functions
- Potassium Balance
- Proximal Tubule and Loop of Henle
- Pulmonary Blood Flow
- Renal Blood Flow (RBF)
- Respiratory Function Tests
- Small Intestine
- Sodium Balance
- Sodium and Water Balance
- Starvation
- Stomach I
- Stomach II – Applied Physiology
- Swallowing
- Synapses I – The Neuromuscular Junction (NMJ)
- Synapses II – Muscarinic Pharmacology
- Synapses III – Nicotinic Pharmacology
- Thyroid Gland
- Valsalva Manoeuvre
- Venous Pressure
- Ventilation/Perfusion Relationships
Summary
1. Which systems of the body show physiologic changes following prolonged immobilization?
The musculoskeletal system
Cardiovascular system
Autonomic nervous system
The extra-cellular fluid compartment
There are also changes in overall body composition of fat and protein
2. What are these changes in the overall body composition that you have mentioned?
Reduction in the lean body mass: this is seen as an increase in the excretion of nitrogen after the 5th day of bed rest. The level of protein catabolism falls after several weeks, but is still higher than normal
Increase of adipose tissue deposition: as a replacement for loss of muscle mass
Increased potassium excretion: since this is the major intracellular cation and especially rich in muscle, loss of potassium is an indicator of loss of total body lean tissue mass
3. How long after continued bed rest are cardiovascular changes seen?
About three weeks.
4. What are these changes?
Increase in heart rate: after three weeks, the rate increases about half a beat per minute per day of immobilization
Reduction of stroke volume: this is associated with a measure of cardiac atrophy
CO and arterial pressure are maintained: owing to the conflicting changes above
Adaptations to postural changes are impaired: this is because of impairment of the inotropic and CO response to a fall in the arterial pressure, despite an exaggerated peripheral vascular response. There is also a reduction in the overall activity of the ANS, leading to a blunting of cardiovascular responses
5. What happens to the musculoskeletal system following three weeks of bed rest?
- Type
- Chapter
- Information
- Applied Surgical Physiology Vivas , pp. 65 - 66Publisher: Cambridge University PressPrint publication year: 2004