Skip to main content Accessibility help
×
Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-22T23:45:57.263Z Has data issue: false hasContentIssue false

7 - Phage evolution

from Part II - Phage evolutionary biology

Published online by Cambridge University Press:  29 September 2009

Stephen T. Abedon
Affiliation:
Ohio State University
Get access

Summary

INTRODUCTION

Bacteriophages have a long history as objects of biological study. They were discovered about 90 years ago and have engaged biologists ever since, initially for their potential in combating human disease through phage therapy. Later, phages served as arguably the most important model systems in the development of the discipline of molecular biology and the associated explosion of knowledge about the detailed workings of genes and cells. Yet it is only in very recent years that the study of phage evolution has attracted the attention of more than a handful of individuals. The primary reasons for the current increased interest in phage evolution, I would suggest, are two: discovery, over the past 20 years, of astonishingly high phage population numbers in the natural environment, and improved, low-cost methods of phage genotypic analysis, especially DNA sequencing. In this chapter I discuss the abundance and diversity of the global phage population, with an emphasis on what we are learning from comparative genomic studies about the mechanisms by which it has evolved to its current state.

Chapter 6 provides an introduction to basic evolutionary mechanisms of phage evolution. See Hendrix (2003), Casjens (2005), and Brüssow and Desiere (2006) for additional reviews of phage evolution from the perspective of genomic studies.

Type
Chapter
Information
Bacteriophage Ecology
Population Growth, Evolution, and Impact of Bacterial Viruses
, pp. 177 - 194
Publisher: Cambridge University Press
Print publication year: 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×