The relationship of Catholic hierarchies with the medium of printing has always been multifarious, and even in early modern times it was far more complex than most current studies maintain. This chapter attempts to draw a concise and unbiased picture of the papacy’s publishing and censoring practices from the 1460s to the 1630s. It starts with the arrival of the first printers in Italy on the outskirts of Rome and ends with the Galileo Galilei affair, analyzing all intervening attempts to use moveable type in support of papal policy and the development of the Index of Forbidden Books. Highlighting the interconnections between prohibition and promotion, it proposes a unified interpretation of these two lines of action rather than present them in opposition, as is often the case.