CBT is, without a doubt, the most familiar psychological intervention. Nevertheless, it is not a unitary treatment. This is evidenced by the variability of CBT protocols used across clinical settings, which can vary in treatment components’ duration and format of delivery. This chapter outlines and focuses upon the diversity of interventions and approaches that fall under the category of CBTx as a system of therapeutics. It also provides rationale for why, given the variety of therapeutic interventions available, CBTx is well suited to a personalised medicine approach to ensure patients are getting the most appropriate treatment for their clinical presentation.