This chapter uses the learnings from Chapter 4’s examples to create the Analysis Rubric, which consists of seven major considerations for determining data science’s applicability to a proposed application. While these considerations may not be fully understood at a project’s inception, there needs to be a belief that answers will be forthcoming prior to completion. Three of these address requirements-oriented aspects (“For What or Why”) of data science applications, and three address implementation-oriented aspects (“How To”). The seventh addresses legal, societal, and ethical implications (ELSI). Collectively, these considerations, or Analysis Rubric elements, cover the complex trade-offs needed to achieve practical, valuable, legal, and ethical results. The chapter concludes by applying the Analysis Rubric to the previous chapter’s examples.