Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2025-01-03T15:30:18.163Z Has data issue: false hasContentIssue false

3 - MHC class I and II pathways for presentation and cross-presentation of bacterial antigens

from I - Dendritic cells and their role in immunity

Published online by Cambridge University Press:  12 August 2009

By
Laurence Bougnères-Vermont  and
Pierre Guermonprez
Edited by
Maria Rescigno
Maria Rescigno
Affiliation:
European Institute of Oncology, Milan
Get access

Summary

DENDRITIC CELLS PRIME ANTI-BACTERIAL CD4+ AND CD8+ T CELLS IN VIVO

It is now widely accepted that dendritic cells (DCs) are crucially required for the priming of T cell responses. Major histo-compatibility complex (MHC) class I and class II presentation pathways ensure the priming of CD8+ and CD4+ T cell, respectively. They thus represent major checkpoints for the induction of adaptative protective immunity toward intracellular bacteria. In this chapter, we will focus on the basic cell biology and physiological regulation of these pathways in the context of bacterial infection. In accordance with the literature, we will refer to “cross presentation” for MHC class I pathways involved in the presentation of non cytosolic antigens.

Listeria, Mycobacteria and Salmonella were shown to actually infect DCs in situ. Some studies have addressed the capacity of DCs purified from infected animals to activate in vitro T cells specific for bacteria-encoded antigens. Intravenous infection of mice with Salmonella and with Mycobacterium bovis BCG (bacillus Calmette-Guérin) leads to the infection of both spleen DC subsets (CD8α− CD11c+ and CD8α+ CD11c+). Both subsets display some MHC class I and II complexes formed after the processing of bacteria-encoded antigens. Bacterial infection may also promote apoptosis, resulting in the delivery of bacterial antigens to DCs upon the phagocytosis of infected apoptotic bodies (see Section 3.5).

Whatever may be the mechanism (infection or dead cells cross presentation), the absolute requirement of DCs to induce anti-bacterial T cell priming was elegantly demonstrated in the Listeria model.

Type
Chapter
Information
Dendritic Cell Interactions with Bacteria , pp. 51 - 78
Publisher: Cambridge University Press
Print publication year: 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Banchereau, J.et al. (1998). Nature 392(6673), 245–52CrossRef
Guermonprez, P.et al. (2002). Ann. Rev. Immunol. 20, 620–67CrossRef
Kolb-Maurer, A.et al. (2000). Infect Immun. 68(6), 3680–8CrossRef
Pron, B.et al. (2001). Cell Microbiol. 3(5), 331–40CrossRef
Bodnar, K. A.et al. (2001). Infect. Immun. 69(2), 800–9CrossRef
Tailleux, L.et al. (2003). J. Exp. Med. 197(1), 121–7CrossRef
Jiao, X.et al. (2002). J. Immunol. 168(3), 1294–301CrossRef
Hopkins, S. A.et al. (2000). Cell Microbiol. 2(1), 59–68CrossRef
Niedergang, F.et al. (2000). Proc. Natl Acad. Sci. U S A 97(26), 14650–5CrossRef
Yrlid, U.et al. (2002). J. Immunol. 169(1), 108–16CrossRef
Svensson, M.et al. (2000). Infect. Immun. 68(11), 6311–20CrossRef
Johansson, C.et al. (2004). J. Immunol. 172(4), 2496–503CrossRef
Yrlid, B. U.et al. (2000). J. Exp. Med. 191(4), 613–24CrossRef
Lenz, L. L.et al. (2000). J. Exp. Med. 192(8), 1135–42CrossRef
Jung, S.et al. (2002). Immunity 17(2), 211–20CrossRef
Yewdell, J. W.et al. (2003). Nat. Rev. Immunol. 3(12), 952–61CrossRef
Rock, K. L.et al. (2004). Nat. Immunol. 5(7), 670–7CrossRef
Kloetzel, P. M. (2004). Nat. Immunol. 5(7), 661–9CrossRef
Cresswell, P. (2000). Traffic 1(4), 301–5CrossRef
Macagno, A.et al. (1999). Eur. J. Immunol. 29(12), 4037–423.0.CO;2-T>CrossRef
Lelouard, H.et al. (2002). Nature 417(6885), 177–82CrossRef
Lelouard, H.et al. (2004). J. Cell Biol. 164(5), 667–75CrossRef
Canadien, V.et al. (2005). J. Immunol. 174(5), 2471–5CrossRef
Gil-Torregrosa, B. C.et al. (2004). Eur. J. Immunol. 34(2), 398–407CrossRef
Ackerman, A. L.et al. (2003). J. Immunol. 170(8), 4178–88CrossRef
Cella, M.et al. (1999). J. Exp. Med. 189(5), 821–9CrossRef
Rescigno, M.et al. (1998). Proc. Natl Acad. Sci. U S A 95(9), 5229–34CrossRef
Delamarre, L.et al. (2003). J. Exp. Med. 198(1), 111–22CrossRef
Pamer, E. G. (2004). Nat. Rev. Immunol. 4(10), 812–23CrossRef
Pamer, E. G.et al. (1997). Immunol. Rev. 158, 129–36CrossRef
Villanueva, M. S.et al. (1994). Immunity 1(6), 479–89CrossRef
Villanueva, M. S.et al. (1995). J. Immunol. 155(11), 5227–33
Princiotta, M. F.et al. (2003). Immunity 18(3), 343–54CrossRef
Sijts, A. J.et al. (1997). J. Biol. Chem. 272(31), 19261–8CrossRef
Shen, H.et al. (1998). Cell 92(4), 535–45CrossRef
Nakagawa, I.et al. (2004). Science 306(5698), 1037–40CrossRef
Ogawa, M.et al. (2005). Science 307(5710), 727–31CrossRef
Rich, K. A.et al. (2003). Cell Microbiol. 5(7), 455–68CrossRef
Portnoy, D. A.et al. (1989). J. Exp. Med. 170(6), 2141–6CrossRef
Tvinnereim, A. R.et al. (2004). J. Immunol. 173(3), 1994–2002CrossRef
Higgins, D. E.et al. (1999). Mol. Microbiol. 31(6), 1631–41CrossRef
Hess, J.et al. (1998). Proc. Natl Acad. Sci. U S A 95(9), 5299–304CrossRef
Russmann, H.et al. (1998). Science 281(5376), 565–8
Guermonprez, P.et al. (1999). J. Immunol. 162(4), 1910–16
Pfeifer, J. D.et al. (1993). Nature 361(6410), 359–62CrossRef
Cheadle, E. J.et al. (2005). Infect. Immun. 73(2), 784–94CrossRef
Winter, N.et al. (1995). Vaccine 13(5), 471–8CrossRef
Faassen, H.et al. (2004). J. Immunol. 172(6), 3491–500CrossRef
Dudani, R.et al. (2002). J. Immunol. 168(11), 5737–45CrossRef
Wick, M. J.et al. (1996). Eur. J. Immunol. 26(11), 2790–9CrossRef
Shen, L.et al. (2004). Immunity 21(2), 155–65CrossRef
Harding, C. V.et al. (1994). J. Immunol. 153(11), 4925–33
Song, R.et al. (1996). J. Immunol. 156(11), 4182–90
Chefalo, P. J.et al. (2003). J. Immunol. 170(12), 5825–33CrossRef
Chefalo, P. J.et al. (2001). J. Immunol. 167(3), 1274–82CrossRef
MacAry, P. A.et al. (2001). Proc. Natl Acad. Sci. U S A 98(7), 3982–7CrossRef
Kleijmeer, M. J.et al. (2001). Traffic 2(2), 124–37CrossRef
Turley, S. J.et al. (2000). Science 288(5465), 522–7CrossRef
Lizee, G.et al. (2003). Nat. Immunol. 4(11), 1065–73CrossRef
McCluskey, J.et al. (1986). EMBO J. 5(10), 2477–83
Vega, M. A.et al. (1989). Proc. Natl Acad. Sci. U S A 86(8), 2688–92CrossRef
Kleijmeer, M.et al. (2001). J. Cell Biol. 155(1), 53–63CrossRef
Chow, A.et al. (2002). Nature 418(6901), 988–94CrossRef
Boes, M.et al. (2002). Nature 418(6901), 983–8CrossRef
Svensson, M.et al. (1999). Eur. J. Immunol. 29(1), 180–83.0.CO;2-W>CrossRef
Brumell, J. H.et al. (2002). Curr. Biol. 12(1), R15–17CrossRef
Stamm, L. M.et al. (2003). J. Exp. Med. 198(9), 1361–8CrossRef
McDonough, K. A.et al. (1993). Infect. Immun. 61(7), 2763–73
Roy, D.et al. (2004). Science 304(5676), 1515–18CrossRef
Beuzon, C. R.et al. (2000). EMBO. J. 19(13), 3235–49CrossRef
Teitelbaum, R.et al. (1999). Proc. Natl Acad. Sci. U S A 96(26), 15190–5CrossRef
Kovacsovics-Bankowski, M.et al. (1995). Science 267(5195), 243–6CrossRef
Sousa, C. Reis eet al. (1995). J. Exp. Med. 182(3), 841–51CrossRef
Oh, Y. K.et al. (1997). Vaccine 15(5), 511–18CrossRef
Norbury, C. C.et al. (1995). Immunity 3(6), 783–91CrossRef
Norbury, C. C.et al. (1997). Eur. J. Immunol. 27(1), 280–8CrossRef
Rodriguez, A.et al. (1999). Nat. Cell Biol. 1(6), 362–8CrossRef
West, M. A.et al. (2004). Science 305(5687), 1153–7CrossRef
Blander, J. M.et al. (2004). Science 304(5673), 1014–18CrossRef
Shiratsuchi, A.et al. (2004). J. Immunol. 172(4), 2039–47CrossRef
Gagnon, E.et al. (2002). Cell 110(1), 119–31CrossRef
Garin, J.et al. (2001). J. Cell Biol. 152, 165–80CrossRef
Guermonprez, P.et al. (2003). Nature 425(6956), 397–402CrossRef
Ackerman, A. L.et al. (2003). Proc. Natl Acad. Sci. USA 100(22), 12889–94CrossRef
Tsai, B.et al. (2002). Nat. Rev. Mol. Cell Biol. 3(4), 246–55CrossRef
Tortorella, D.et al. (2000). Annu. Rev. Immunol. 18, 861–926CrossRef
Wiertz, E. J.et al. (1996). Nature 384(6608), 432–8CrossRef
Tirosh, B.et al. (2003). J. Biol. Chem. 278(9), 6664–72CrossRef
Lilley, B. N.et al. (2004). Nature 429(6994), 834–40CrossRef
Ye, Y.et al. (2004). Nature 429(6994), 841–7CrossRef
Ye, Y.et al. (2001). Nature 414(6864), 652–6CrossRef
Houde, M.et al. (2003). Nature 425(6956), 402–6CrossRef
Ackerman, A. L.et al. (2005). Nat. Immunol. 6(1), 107–13CrossRef
Roy, C. R. (2005). Proc. Natl Acad. Sci. U S A 102(5), 1271–2CrossRef
Celli, J.et al. (2003). J. Exp. Med. 198(4), 545–56CrossRef
Celli, J.et al. (2004). Curr. Opin. Microbiol. 7(1), 93–7CrossRef
Nagai, H.et al. (2002). Science 295(5555), 679–82CrossRef
Kagan, J. C.et al. (2004). J. Exp. Med. 199(9), 1201–11CrossRef
McNew, J. A.et al. (2000). Nature 407(6801), 153–9
Becker, T.et al. (2005). Proc. Natl Acad. Sci. U S A 102(11), 4022–6CrossRef
Trombetta, E. S.et al. (2005). Annu. Rev. Immunol. 23, 975–1028CrossRef
Wilson, N. S.et al. (2005). Adv. Immunol. 86, 241–305CrossRef
Lutz, M. B.et al. (1997). J. Immunol. 159(8), 3707–16
Pierre, P.et al. (1998). Cell 93(7), 1135–45CrossRef
Trombetta, E. S.et al. (2003). Science 299(5611), 1400–3CrossRef
Wilson, N. S.et al. (2004). Blood 103(6), 2187–95CrossRef
Delamarre, L.et al. (2005). Science 307(5715), 1630–4CrossRef
Ramachandra, L.et al. (1999). J. Immunol. 162(6), 3263–72
Ramachandra, L.et al. (2000). J. Immunol. 164(10), 5103–12CrossRef
Ramachandra, L.et al. (2001). J. Exp. Med. 194(10), 1421–32CrossRef
Geginat, G.et al. (2001). J. Immunol. 166(3), 1877–84CrossRef
Skoberne, M.et al. (2002). J. Immunol. 168(4), 1854–60CrossRef
Skoberne, M.et al. (2002). J. Immunol. 169(3), 1410–18CrossRef
Tewari, M. K.et al. (2005). Nat. Immunol. 6(3), 287–94CrossRef
Dani, A.et al. (2004). J. Cell Sci. 117(Pt 18), 4219–30CrossRef
Cuervo, A. M.et al. (1998). J. Mol. Med. 76(1), 6–12CrossRef
Zhou, D.et al. (2005). Immunity 22(5), 571–81CrossRef
Paludan, C.et al. (2005). Science 307(5709), 593–6CrossRef
Dengjel, J.et al. (2005). Proc. Natl Acad. Sci. U S A 102(22), 7922–7CrossRef
Yoshimori, T. (2004). Biochem. Biophys. Res. Commun. 313(2), 453–8CrossRef
Macpherson, A. J.et al. (2004). Science 303(5664), 1662–5CrossRef
Macpherson, A. J.et al. (2000). Science 288(5474), 2222–6CrossRef
Garcia-Del Portillo, F.et al. (2000). Infect. Immun. 68(5), 2985–91CrossRef
Scott, C. C.et al. (2003). J. Membr. Biol. 193(3), 137–52CrossRef
Sturgill-Koszycki, S.et al. (1994). Science 263(5147), 678–81CrossRef
Vergne, I.et al. (2004). Annu. Rev. Cell Dev. Biol. 20, 367–94CrossRef
Fratti, R. A.et al. (2001). J. Cell Biol. 154(3), 631–44CrossRef
Fratti, R. A.et al. (2003). Proc. Natl Acad. Sci. U S A 100(9), 5437–42CrossRef
Vergne, I.et al. (2003). J. Exp. Med. 198(4), 653–9CrossRef
Vergne, I.et al. (2005). Proc. Natl Acad. Sci. U S A 102(11), 4033–8CrossRef
Gordon, A. H.et al. (1994). Infect. Immun. 62(10), 4650–1
Harding, C. V.et al. (2003). Curr. Opin. Immunol. 15(1), 112–19CrossRef
Ramachandra, L.et al. (2005). Infect. Immun. 73(2), 1097–105CrossRef
Hmama, Z.et al. (1998). J. Immunol. 161(9), 4882–93
Chan, J.et al. (2004). Clin. Immunol. 110(1), 2–12CrossRef
Jantsch, J.et al. (2003). Cell Microbiol. 5(12), 933–45CrossRef
Cheminay, C.et al. (2005). J. Immunol. 174(5), 2892–9CrossRef
Tobar, J. A.et al. (2004). J. Immunol. 173(6), 4058–65CrossRef
Tailleux, L.et al. (2003). J. Immunol. 170(4), 1939–48CrossRef
Neild, A. L.et al. (2003). Immunity 18(6), 813–23CrossRef
Bevan, M. J. (1976). J. Exp. Med. 143(5), 1283–8CrossRef
Heath, W. R.et al. (2004). Immunol. Rev. 199, 9–26CrossRef
Yewdell, J. W.et al. (2005). Annu. Rev. Immunol. 23, 651–82CrossRef
Ramirez, M. C.et al. (2002). J. Immunol. 169(12), 6733–42CrossRef
Fonteneau, J. F.et al. (2003). Blood 102(13), 4448–55CrossRef
Guermonprez, P.et al. (2005). Springer Semin. Immunopathol. 26(3), 257–71CrossRef
Shen, L.et al. (2004). Proc. Natl Acad. Sci. U S A 101(9), 3035–40CrossRef
Wolkers, M. C.et al. (2004). Science 304(5675), 1314–17CrossRef
Norbury, C. C.et al. (2004). Science 304(5675), 1318–21CrossRef
Blachere, N. E.et al. (2005). PLoS Biol. 3(6), e185.CrossRef
Binder, R. J.et al. (2005). Nat. Immunol. 6(6), 593–9CrossRef
Srivastava, P. (2002). Nat. Rev. Immunol. 2(3), 185–94CrossRef
Tobian, A. A.et al. (2004). J. Immunol. 172(9), 5277–86CrossRef
Schaible, U. E.et al. (2003). Nat. Med. 9(8), 1039–46CrossRef
Wijburg, O. L.et al. (2002). J. Immunol. 169(6), 3275–83CrossRef
Wong, P.et al. (2003). Immunity 18(4), 499–511CrossRef
Janda, J.et al. (2004). J. Immunol. 173(9), 5644–51CrossRef

Save book to Kindle

To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×