Skip to main content Accessibility help
×
Hostname: page-component-cd9895bd7-gvvz8 Total loading time: 0 Render date: 2024-12-24T03:20:32.534Z Has data issue: false hasContentIssue false

Chapter 8.2 - Fetal dysrhythmias

Clinical management

from Section 2 - Fetal disease

Published online by Cambridge University Press:  05 February 2013

Mark D. Kilby
Affiliation:
Department of Fetal Medicine, University of Birmingham
Anthony Johnson
Affiliation:
Baylor College of Medicine, Texas
Dick Oepkes
Affiliation:
Department of Obstetrics, Leiden University Medical Center
Get access

Summary

Introduction

Assessment of fetal heart rate (FHR) and its regularity is part of clinical management of all pregnancies during routine antenatal visits. By simple auscultation of the fetal heart, doctors and midwives can promptly detect abnormal patterns (“fetal dysrhythmia”) and therefore, bradycardias, tachycardias, and irregular rhythms are easily recognized.

However, whilst identifying a dysrhythmia should prompt further assessment in all cases, having a basic understanding of the various diagnostic possibilities leading to rhythm disturbances is important. Establishing a local protocol to guide referral may be the first step to manage the rhythm abnormality in a timely and safe manner. This way, most families can be appropriately reassured and the fewer cases for whom fetal monitoring and therapy may be indicated can be seen by a specialist without delay.

At specialist level, accurate assessment of the rhythm abnormality, its hemodynamic consequences and assessment of fetal well-being will determine the need for fetal intervention. In this chapter, we aim to provide a logical approach to diagnosis (primarily based on ultrasound) and discuss current management of fetal dysrhythmias.

Type
Chapter
Information
Fetal Therapy
Scientific Basis and Critical Appraisal of Clinical Benefits
, pp. 87 - 99
Publisher: Cambridge University Press
Print publication year: 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Glickstein, JS, Buyon, J, Friedman, D. Pulsed Doppler echocardiographic assessment of the fetal PR interval. Am J Cardiol 2000;86(2):236–9.Google Scholar
Fouron, JC, Fournier, A, Proulx, F, et al. Management of fetal tachyarrhythmia based on superior vena cava/aorta Doppler flow recordings. Heart 2003;89(10):1211–16.Google Scholar
Carvalho, JS, Prefumo, F, Ciardelli, V, et al. Evaluation of fetal arrhythmias from simultaneous pulsed wave Doppler in pulmonary artery and vein. Heart 2007;93(11):1448–53.Google Scholar
Rein, AJ, O’Donnell, C, Geva, T, et al. Use of tissue velocity imaging in the diagnosis of fetal cardiac arrhythmias. Circulation 2002;106(14):1827–33.Google Scholar
Chia, EL, Ho, TF, Rauff, M, et al. Cardiac time intervals of normal fetuses using noninvasive fetal electrocardiography. Prenat Diagn 2005;25(7):546–52.Google Scholar
Strasburger, JF, Wakai, RT. Fetal cardiac arrhythmia detection and in utero therapy. Nat Rev Cardiol 2010;7(5):277–90.Google Scholar
Rasiah, SV, Ewer, AK, Miller, P, et al. Prenatal diagnosis, management and outcome of fetal dysrhythmia: a tertiary fetal medicine centre experience over an eight-year period. Fetal Diagn Ther 2011;30(2):122–7.Google Scholar
Fouron, JC. Fetal arrhythmias: the Saint-Justine hospital experience. Prenat Diagn 2004;24(13):1068–80.Google Scholar
Copel, JA, Liang, RI, Demasio, K, et al. The clinical significance of the irregular fetal heart rhythm. Am J Obstet Gynecol 2000;182(4):813–17.Google Scholar
Simpson, JL, Yates, RW, Sharland, GK. Irregular heart rate in the fetus: not always benign. Cardiol Young 1996;6:28–31.Google Scholar
Cuneo, BF, Strasburger, JF, Wakai, RT, et al. Conduction system disease in fetuses evaluated for irregular cardiac rhythm. Fetal Diagn Ther 2006;21(3):307–13.Google Scholar
Srinivasan, S, Strasburger, J. Overview of fetal arrhythmias. Curr Opin Pediatr 2008;20(5):522–31.Google Scholar
Eliasson, H, Wahren-Herlenius, M, Sonesson, SE. Mechanisms in fetal bradyarrhythmia: 65 cases in a single center analyzed by Doppler flow echocardiographic techniques. Ultrasound Obstet Gynecol 2011;37(2):172–8.Google Scholar
Krapp, M, Kohl, T, Simpson, JM, et al. Review of diagnosis, treatment, and outcome of fetal atrial flutter compared with supraventricular tachycardia. Heart 2003;89(8):913–17.Google Scholar
Jaeggi, ET, Carvalho, JS, De Groot, E, et al. Comparison of transplacental treatment of fetal supraventricular tachycardia with digoxin, flecainide and sotalol: results of a non-randomised multicenter study. Circulation 2011;124(16):1747–54.Google Scholar
Kleinman, CS, Nehgme RA. Cardiac arrhythmias in the human fetus. Pediatr Cardiol 2004;25(3):234–51.Google Scholar
Kleinman, CS, Copel, JA. Electrophysiological principles and fetal antiarrhythmic therapy. Ultrasound Obstet Gynecol 1991;1(4):286–97.Google Scholar
Gembruch U. Fetal tachyarrhythmia. In: Yagel, S, Silverman, NH, Gembruch, U, eds. Fetal Cardiology, 2nd edn. New York, Informa Healthcare. 2009; 461–81.
Strasburger, JF. Prenatal diagnosis of fetal arrhythmias. Clin Perinatol 2005;32(4):891–912Google Scholar
Oudijk, MA, Stoutenbeek, P, Sreeram, N, et al. Persistent junctional reciprocating tachycardia in the fetus. J Matern Fetal Neonatal Med 2003;13(3):191–6.Google Scholar
Jaeggi, E, Fouron, JC, Drblik, SP. Fetal atrial flutter: diagnosis, clinical features, treatment, and outcome. J Pediatr 1998;132(2):335–9.Google Scholar
Jaeggi, ET, Nii, M. Fetal brady- and tachyarrhythmias: new and accepted diagnostic and treatment methods. Semin Fetal Neonatal Med 2005;10(6):504–14.Google Scholar
Simpson, JM, Sharland, GK. Fetal tachycardias: management and outcome of 127 consecutive cases. Heart 1998;79(6):576–81.Google Scholar
Hansmann, M, Gembruch, U, Bald, R, et al. Fetal tachyarrhythmias: transplacental and direct treatment of the fetus – a report of 60 cases. Ultrasound Obstet Gynecol 1991; 1(3);162–8.Google Scholar
Strasburger, JF, Cuneo, BF, Michon, MM, et al. Amiodarone therapy for drug-refractory fetal tachycardia. Circulation 2004;109(3):375–9.Google Scholar
Jouannic, JM, Delahaye, S, Fermont, L, et al. Fetal supraventricular tachycardia: a role for amiodarone as second-line therapy? Prenat Diagn 2003;23(2):152–6.Google Scholar
Allan, LD, Chita, SK, Sharland, GK, et al. Flecainide in the treatment of fetal tachycardias. Br Heart J 1991;65(1):46–8.Google Scholar
American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 106: Intrapartum fetal heart rate monitoring: nomenclature, interpretation, and general management principles. Obstet Gynecol 2009;114(1):192–202.Google Scholar
Serra, V, Bellver, J, Moulden, M, et al. Computerized analysis of normal fetal heart rate pattern throughout gestation. Ultrasound Obstet Gynecol 2009;34(1):74–9.Google Scholar
Baruteau, AE, Schleich, JM. Antenatal presentation of congenital long QT syndrome: a prenatal diagnosis not to be missed. Pediatr Cardiol 2008;29(6):1131–2.Google Scholar
Berg, C, Geipel, A, Kohl, T, et al. Atrioventricular block detected in fetal life: associated anomalies and potential prognostic markers. Ultrasound Obstet Gynecol 2005;26(1):4–15.Google Scholar
Glatz, AC, Gaynor, JW, Rhodes, LA, et al. Outcome of high-risk neonates with congenital complete heart block paced in the first 24 hours after birth. J Thorac Cardiovasc Surg 2008;136(3):767–73.Google Scholar
Lopes, LM, Tavares, GM, Damiano, AP, et al. Perinatal outcome of fetal atrioventricular block: one-hundred-sixteen cases from a single institution. Circulation 2008;118(12):1268–75.Google Scholar
Baruteau, A-E, Schott, J-J, Villain, E, et al. Non-immune isolated atrioventricular block in childhood: a French multicentric study [Abstract AB19–1]. Heart Rhythm 2009;6(5, Supplement 1):S39.Google Scholar
Eliasson, H, Sonesson, SE, Sharland, G, et al. Isolated atrioventricular block in the fetus: a retrospective multinational, multicentre study of 175 patients. Circulation 2011;124(18):1919–26.Google Scholar
Moak, JP, Barron, KS, Hougen, TJ, et al. Congenital heart block: development of late-onset cardiomyopathy, a previously underappreciated sequela. J Am Coll Cardiol 2001;37(1):238–42.Google Scholar
Buyon, JP, Hiebert, R, Copel, J, et al. Autoimmune-associated congenital heart block: demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry. J Am Coll Cardiol 1998;31(7):1658–66.Google Scholar
Schmidt, KG, Ulmer, HE, Silverman, NH, et al. Perinatal outcome of fetal complete atrioventricular block: a multicenter experience. J Am Coll Cardiol 1991;17(6):1360–6.Google Scholar
Groves, AM, Allan, LD, Rosenthal, E. Outcome of isolated congenital complete heart block diagnosed in utero. Heart 1996;75(2):190–4.Google Scholar
Friedman, DM, Kim, MY, Copel, JA, et al. Utility of cardiac monitoring in fetuses at risk for congenital heart block. The PR Interval and Dexamethasone Evaluation (PRIDE) prospective study. Circulation 2008;117:485–93.Google Scholar
Jaeggi, E, Laskin, C, Hamilton, R, et al. The importance of the level of maternal anti-Ro/SSA antibodies as a prognostic marker of the development of cardiac neonatal lupus erythematosus: a prospective study of 186 antibody-exposed fetuses and infants. J Am Coll Cardiol 2010;55(24):2778–84.Google Scholar
Saleeb, S, Copel, J, Friedman, D, et al. Comparison of treatment with fluorinated glucocorticoids to the natural history of autoantibody-associated congenital heart block: retrospective review of the research registry for neonatal lupus. Arthritis Rheum 1999;42(11):2335–45.Google Scholar
Jaeggi, ET, Fouron, JC, Silverman, ED, et al. Transplacental fetal treatment improves the outcome of prenatally diagnosed complete atrioventricular block without structural heart disease. Circulation 2004;110(12):1542–8.Google Scholar
Groves, AM, Allan, LD, Rosenthal, E. Therapeutic trial of sympathomimetics in three cases of complete heart block in the fetus. Circulation 1995;92(12):3394–6.Google Scholar
Cuneo, BF, Zhao, H, Strasburger, JF, et al. Atrial and ventricular rate response and patterns of heart rate acceleration during maternal-fetal terbutaline treatment of fetal complete heart block. Am J Cardiol 2007;100(4):661–5.Google Scholar
Pisoni, CN, Brucato, A, Ruffatti, A, et al. Failure of intravenous immunoglobulin to prevent congenital heart block: findings of a multicenter, prospective, observational study. Arthritis Rheum 2010;62(4):1147–52.Google Scholar
Friedman, DM, Llanos, C, Izmirly, PM, et al. Evaluation of fetuses in a study of intravenous immunoglobulin as preventive therapy for congenital heart block: results of a multicenter, prospective, open-label clinical trial. Arthritis Rheum 2010;62(4):1138–46.Google Scholar
Miyakata, S, Takeuchi, K, Yamaji, K, et al. Therapeutic plasmapheresis for the prevention of congenital complete heart block associated with anti-SS-A/Ro antibody and anti-SS-B/La antibody. Ryumachi 2001;41(4):726–35.Google Scholar
Assad, RS, Zielinsky, P, Kalil, R, et al. New lead for in utero pacing for fetal congenital heart block. J Thorac Cardiovasc Surg 2003;126(1):300–2.Google Scholar
Boudjemline, Y, Rosenblatt, J, de La Villeon, G, et al. Development of a new lead for in utero fetal pacing. Prenat Diagn 2010;30(2):122–6.Google Scholar
Hutter, D, Silverman, ED, Jaeggi, ET. The benefits of transplacental treatment of isolated congenital complete heart block associated with maternal anti-Ro/SSA antibodies: a review. Scand J Immunol 2010;72(3):235–41.Google Scholar
Matsushita, H, Higashino, M, Sekizuka, N, et al. Successful prenatal treatment of congenital heart block with ritodrine administered transplacentally. Arch Gynecol Obstet 2002;267(1):51–3.Google Scholar
Friedman, DM, Kim, MY, Copel, JA, et al. Prospective evaluation of fetuses with autoimmune-associated congenital heart block followed in the PR Interval and Dexamethasone Evaluation (PRIDE) Study. Am J Cardiol 2009;103(8):1102–6.Google Scholar
Rein, AJ, Mevorach, D, Perles, Z, et al. Early diagnosis and treatment of atrioventricular block in the fetus exposed to maternal anti-SSA/Ro-SSB/La antibodies. A prospective, observational, fetal kinetocardiogram-based study. Circulation 2009;119:1867–72.Google Scholar
Jaeggi, ET, Silverman, ED, Laskin, C, et al. Prolongation of the atrioventricular conduction in fetuses exposed to maternal anti-Ro/SSA and anti-La/SSB antibodies did not predict progressive heart block. A prospective observational study on the effects of maternal antibodies on 165 fetuses. J Am Coll Cardiol 2011;57(13):1487–92.Google Scholar
Sonesson, SE, Salomonsson, S, Jacobsson, LA, et al. Signs of first-degree heart block occur in one-third of fetuses of pregnant women with anti-SSA/Ro 52-kd antibodies. Arthritis Rheum 2004;50(4):1253–61.Google Scholar
Rein, AJ, Mevorach, D, Perles, Z, et al. Fetal first-degree heart block, or where to set the confidence limit: comment on the article by Sonesson et al. Arthritis Rheum 2005;52(1):366–8.Google Scholar
Buyon, JP, Askanase, AD, Kim, MY, et al. Identifying an early marker for congenital heart block: when is a long PR interval too long? Comment on the article by Sonesson et al. Arthritis Rheum 2005;52(4):1341–2.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×