Book contents
- The Genetics of African Populations in Health and Disease
- Cambridge Studies in Biological and Evolutionary Anthropology
- The Genetics of African Populations in Health and Disease
- Copyright page
- Contents
- Contributors
- 1 Reflections on Conceptualizing Africa for Biological Studies with a Historical Component
- 2 History and Genetics in Africa
- 3 Disease, Selection, and Evolution in the African Landscape
- 4 Genetic Susceptibility to Visceral Leishmaniasis
- 5 Genetics of Infection in Sub-Saharan Africa
- 6 Pharmacogenomics and Infectious Diseases in Africa
- 7 A Glimpse into Pharmacogenomics in Africa
- 8 Genomics of Cardiometabolic Disorders in Sub-Saharan Africa
- 9 Breast Cancer in African Populations
- 10 Sociobiological Transition and Cancer
- 11 The Genetic Epidemiology of Orphan Diseases in North Africa
- 12 Birth Defects and Genetic Disease in Sub-Saharan Africa
- 13 Neurogenetic Disorders in Africa: Hereditary Spastic Paraplegia
- 14 Enabling Genomic Revolution in Africa
- Index
- References
13 - Neurogenetic Disorders in Africa: Hereditary Spastic Paraplegia
A Case Study
Published online by Cambridge University Press: 02 December 2019
Book contents
- The Genetics of African Populations in Health and Disease
- Cambridge Studies in Biological and Evolutionary Anthropology
- The Genetics of African Populations in Health and Disease
- Copyright page
- Contents
- Contributors
- 1 Reflections on Conceptualizing Africa for Biological Studies with a Historical Component
- 2 History and Genetics in Africa
- 3 Disease, Selection, and Evolution in the African Landscape
- 4 Genetic Susceptibility to Visceral Leishmaniasis
- 5 Genetics of Infection in Sub-Saharan Africa
- 6 Pharmacogenomics and Infectious Diseases in Africa
- 7 A Glimpse into Pharmacogenomics in Africa
- 8 Genomics of Cardiometabolic Disorders in Sub-Saharan Africa
- 9 Breast Cancer in African Populations
- 10 Sociobiological Transition and Cancer
- 11 The Genetic Epidemiology of Orphan Diseases in North Africa
- 12 Birth Defects and Genetic Disease in Sub-Saharan Africa
- 13 Neurogenetic Disorders in Africa: Hereditary Spastic Paraplegia
- 14 Enabling Genomic Revolution in Africa
- Index
- References
Summary
Many regions of Africa, the continent where the sun is always shining, are gradually becoming overwhelmed by genetic disorders, especially where consanguineous marriages are strongly favored over many generations. In this chapter we navigate through the genetic and phenotypic features observed in some African populations, using hereditary spastic paraplegia (HSP) as a model of neurogenetic disorders. Published data and unpublished studies on HSP are starting to disclose criteria that distinguish these populations due to an interesting mixture of environmental factors, traditions, and certain characteristics of African genomes.
- Type
- Chapter
- Information
- The Genetics of African Populations in Health and Disease , pp. 311 - 319Publisher: Cambridge University PressPrint publication year: 2019
References
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