From 1720 to 1722, the French region of Provence and surrounding areas experienced one of the last major epidemics of plague to strike Western Europe. The Plague of Provence (or Great Plague of Marseilles) was a major disaster that left in its wake as many as 126,000 deaths, as well as new understandings about the nature of contagion and how best to manage its threat. Although the infection never left southeastern France, all of Europe, the Mediterranean, the Atlantic, and parts of Asia mobilized against its threat, and experienced its social, commercial, and diplomatic repercussions. Accordingly, this transnational study explores responses to this biological threat in some of the foremost port cities of the eighteenth-century world, including Marseilles, Genoa, London, Cádiz—the principal port for the Carrera de Indias or Route to the Indies – as well as some of the principal colonial towns with which these cities were most closely associated. In this way, this book reveals the ways in which a crisis in one part of the globe can yet transcend geographic and temporal boundaries to influence society, politics, and public health policy in regions far removed from the epicenter of disaster.