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Chapter 25 - Donor Lymphocyte Infusion: Rationale, Benefits, and Limitations

from Section 8 - Prevention, Detection, and Treatment of Relapse after Hematopoietic Cell Transplants

Published online by Cambridge University Press:  24 May 2017

Hillard M. Lazarus
Affiliation:
Case Western Reserve University, Ohio
Robert Peter Gale
Affiliation:
Imperial College London
Armand Keating
Affiliation:
University of Toronto
Andrea Bacigalupo
Affiliation:
Ospedale San Martino, Genoa
Reinhold Munker
Affiliation:
Louisiana State University, Shreveport
Kerry Atkinson
Affiliation:
University of Queensland
Syed Ali Abutalib
Affiliation:
Midwestern Regional Medical Center, Cancer Treatment Centers of America, Chicago
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Chapter
Information
Hematopoietic Cell Transplants
Concepts, Controversies and Future Directions
, pp. 223 - 231
Publisher: Cambridge University Press
Print publication year: 2000

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References

Goldman, JM, Gale, RP, Horowitz, MM, Biggs, JC, Champlin, RE, Gluckman, E, et al. Bone marrow transplantation for chronic myelogenous leukemia in chronic phase. Increased risk for relapse associated with T-cell depletion. Ann Intern Med. 1988;108(6):806–14. PubMed PMID: 3285744.CrossRefGoogle ScholarPubMed
Kolb, HJ, Mittermuller, J, Clemm, C, Holler, E, Ledderose, G, Brehm, G, et al. Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood. 1990;76(12):2462–5. PubMed PMID: 2265242.CrossRefGoogle ScholarPubMed
Dazzi, F, Szydlo, RM, Cross, NC, Craddock, C, Kaeda, J, Kanfer, E, et al. Durability of responses following donor lymphocyte infusions for patients who relapse after allogeneic stem cell transplantation for chronic myeloid leukemia. Blood. 2000;96(8):2712–6. PubMed PMID: 11023502.CrossRefGoogle ScholarPubMed
Craddock, C, Szydlo, RM, Klein, JP, Dazzi, F, Olavarria, E, van Rhee, F, et al. Estimating leukemia-free survival after allografting for chronic myeloid leukemia: a new method that takes into account patients who relapse and are restored to complete remission. Blood. 2000;96(1):8690. PubMed PMID: 10891435.CrossRefGoogle ScholarPubMed
Mackinnon, S, Papadopoulos, EB, Carabasi, MH, Reich, L, Collins, NH, Boulad, F, et al. Adoptive immunotherapy evaluating escalating doses of donor leukocytes for relapse of chronic myeloid leukemia after bone marrow transplantation: separation of graft-versus-leukemia responses from graft-versus-host disease. Blood. 1995;86(4):1261–8. PubMed PMID: 7632930.CrossRefGoogle ScholarPubMed
van Rhee, F, Savage, D, Blackwell, J, Orchard, K, Dazzi, F, Lin, F, et al. Adoptive immunotherapy for relapse of chronic myeloid leukemia after allogeneic bone marrow transplant: equal efficacy of lymphocytes from sibling and matched unrelated donors. Bone Marrow Transplant. 1998;21(10):1055–61. PubMed PMID: 9632281.CrossRefGoogle ScholarPubMed
Simula, MP, Marktel, S, Fozza, C, Kaeda, J, Szydlo, RM, Nadal, E, et al. Response to donor lymphocyte infusions for chronic myeloid leukemia is dose-dependent: the importance of escalating the cell dose to maximize therapeutic efficacy. Leukemia. 2007;21(5):943–8. PubMed PMID: 17361226. Epub 2007/03/16. eng.CrossRefGoogle ScholarPubMed
Dazzi, F, Szydlo, RM, Craddock, C, Cross, NC, Kaeda, J, Chase, A, et al. Comparison of single-dose and escalating-dose regimens of donor lymphocyte infusion for relapse after allografting for chronic myeloid leukemia. Blood. 2000;95(1):6771. PubMed PMID: 10607686.CrossRefGoogle ScholarPubMed
Fozza, C, Szydlo, RM, Abdel-Rehim, MM, Nadal, E, Goldman, JM, Apperley, JF, et al. Factors for graft-versus-host disease after donor lymphocyte infusions with an escalating dose regimen: lack of association with cell dose. Bri J Haematol. 2007;136(6):833–6. PubMed PMID: 17341269. Epub 2007/03/08. eng.Google ScholarPubMed
Ferrara, JL, Levine, JE, Reddy, P, Holler, E. Graft-versus-host disease. Lancet. 2009;373(9674):1550–61. PubMed PMID: 19282026. Pubmed Central PMCID: 2735047. Epub 2009/03/14. eng.CrossRefGoogle ScholarPubMed
Vianello, F, Cannella, L, Coe, D, Chai, JG, Golshayan, D, Marelli-Berg, FM, et al. Enhanced and aberrant T cell trafficking following total body irradiation: a gateway to graft-versus-host disease? Br J Haematol. 2013;162(6):808–18. PubMed PMID: 23855835.CrossRefGoogle ScholarPubMed
Bar, M, Sandmaier, BM, Inamoto, Y, Bruno, B, Hari, P, Chauncey, T, et al. Donor lymphocyte infusion for relapsed hematological malignancies after allogeneic hematopoietic cell transplantation prognostic relevance of the initial CD3+ T cell dose. Biol Blood Marrow Transplant. 2013 19(6):949–57.CrossRefGoogle ScholarPubMed
Schmid, C, Schleuning, M, Hentrich, M, Markl, GE, Gerbitz, A, Tischer, J, et al. High antileukemic efficacy of an intermediate intensity conditioning regimen for allogeneic stem cell transplantation in patients with high-risk acute myeloid leukemia in first complete remission. Bone Marrow Transplant. 2008;41(8):721–7.CrossRefGoogle ScholarPubMed
Schmid, C, Labopin, M, Nagler, A, Bornhauser, M, Finke, J, Fassas, A et al. Donor lymphocyte infusion in the treatment of first hematological relapse after allogeneic stem-cell transplantation in adults with acute myeloid leukemia: a retrospective risk factors analysis and comparison with other strategies by the EBMT Acute Leukemia Working Party. J Clin Oncol. 2007;25:4938–45.CrossRefGoogle ScholarPubMed
Campregher, PV, Gooley, T, Scott, BL, Moravec, C, Sandmaier, B, Martin, PJ, et al. Results of donor lymphocyte infusions for relapsed myelodysplastic syndrome after hematopoietic cell transplantation. Bone Marrow Transplant. 2007;40(10):965–71.CrossRefGoogle ScholarPubMed
Elliott, MA, Tefferi, A, Hogan, WJ, Letendre, L, Gastineau, DA, Ansell, SM, et al. Allogeneic stem cell transplantation and donor lymphocyte infusions for chronic myelomonocytic leukemia. Bone Marrow Transplant. 2006; 37(11):1003–8.CrossRefGoogle ScholarPubMed
Krishnamurthy, P, Potter, VT, Barber, LD, Kulasekararaj, AG, Lim, ZY, Pearce, RM, de Lavallade, H, et al. Outcome of donor lymphocyte infusion after T cell-depleted allogeneic hematopoietic stem cell transplantation for acute myelogenous leukemia and myelodysplastic syndromes. Biol Blood Marrow Transplant. 2013;19(4):562–8.CrossRefGoogle Scholar
Liga, M, Triantafyllou, E, Tiniakou, M, Lambropoulou, P, Karakantza, M, Zoumbos, NC, et al. High alloreactivity of low-dose prophylactic donor lymphocyte infusion in patients with acute leukemia undergoing allogeneic hematopoietic cell transplantation with an alemtuzumab-containing conditioning regimen. Biol Blood Marrow Transplant. 2013;19(1):7581.CrossRefGoogle ScholarPubMed
Schroeder, T, Fröbel, J, Cadeddu, RP, Czibere, A, Dienst, A, Platzbecker, U, et al. Salvage therapy with azacitidine increases regulatory T cells in peripheral blood of patients with AML or MDS and early relapse after allogeneic blood stem cell transplantation. Leukemia. 2013;27(9):1910–3.Google ScholarPubMed
McLornan, DP, Mead, AJ, Jackson, G, Harrison, CN. Allogeneic stem cell transplantation for myelofibrosis in 2012. Br J Haematol. 2012;157(4):413–25.CrossRefGoogle ScholarPubMed
Kröger, N, Alchalby, H, Klyuchnikov, E, Badbaran, A, Hildebrandt, Y, Ayuk, F, et al. JAK2-V617F-triggered preemptive and salvage adoptive immunotherapy with donor-lymphocyte infusion in patients with myelofibrosis after allogeneic stem cell transplantation. Blood. 2009;113(8):1866–8.CrossRefGoogle ScholarPubMed
Yoshimi, A, Bader, P, Matthes-Martin, S, Stary, J, Sedlacek, P, Duffner, U et al. Donor leukocyte infusion after hematopoietic stem cell transplantation in patients with juvenile myelomonocytic leukemia. Leukemia 2005;19:971–7.CrossRefGoogle ScholarPubMed
El-Jurdi, N, Reljic, T, Kumar, A, Pidala, J, Bazarbachi, A, Djulbegovic, B, et al. Efficacy of adoptive immunotherapy with donor lymphocyte infusion in relapsed lymphoid malignancies. Immunotherapy. 2013;5(5):457–66.CrossRefGoogle ScholarPubMed
Bloor, AJ, Thomson, K, Chowdhry, N, Verfuerth, S, Ings, SJ, Chakraverty, R, et al. High response rate to donor lymphocyte infusion after allogeneic stem cell transplantation for indolent non-Hodgkin lymphoma. Biol Blood Marrow Transplant. 2008;14(1):50–8.CrossRefGoogle ScholarPubMed
Thomson, KJ, Morris, EC, Milligan, D, Parker, AN, Hunter, AE, Cook, G, et al. T-cell-depleted reduced-intensity transplantation followed by donor leukocyte infusions to promote graft-versus-lymphoma activity results in excellent long-term survival in patients with multiply relapsed follicular lymphoma. J Clin Oncol. 2010;28(23):3695–700.CrossRefGoogle ScholarPubMed
Peggs, KS, Kayani, I, Edwards, N, Kottaridis, P, Goldstone, AH, Linch, DC et al. Donor lymphocyte infusions modulate relapse risk in mixed chimeras and induce durable salvage in relapsed patients after T-cell-depleted allogeneic transplantation for Hodgkin’s lymphoma. J Clin Oncol. 2011;29(8):971–8.CrossRefGoogle ScholarPubMed
Theurich, S, Malcher, J, Wennhold, K, Shimabukuro-Vornhagen, A, Chemnitz, J, Holtick, U, et al. Brentuximab vedotin combined with donor lymphocyte infusions for early relapse of Hodgkin lymphoma after allogeneic stem-cell transplantation induces tumor-specific immunity and sustained clinical remission. J Clin Oncol. 2013;31(5):e59-63.CrossRefGoogle ScholarPubMed
Sala, E, Crocchiolo, R, Gandolfi, S, Bruno-Ventre, M, Bramanti, S, Peccatori, J, et al. Bendamustine combined with donor lymphocytes infusion in Hodgkin’s lymphoma relapsing after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2014;20(9):1444–7.CrossRefGoogle ScholarPubMed
Richardson, SE, Khan, I, Rawstron, A, Sudak, J, Edwards, N, Verfuerth, S, et al. Risk-stratified adoptive cellular therapy following allogeneic hematopoietic stem cell transplantation for advanced chronic lymphocytic leukaemia. Br J Haematol. 2013;160(5):640–8.CrossRefGoogle ScholarPubMed
Slavin, S, Naparstek, E, Nagler, A, Ackerstein, A, Samuel, S, Kapelushnik, J et al. Allogeneic cell therapy with donor peripheral blood cells and recombinant human interleukin-2 to treat leukemia relapse after allogeneic bone marrow transplantation. Blood 1996; 87:2195–204.CrossRefGoogle ScholarPubMed
Collins, RH Jr., Goldstein, S, Giralt, S, Levine, J, Porter, D, Drobyski, W et al. Donor leukocyte infusions in acute lymphocytic leukemia. Bone Marrow Transplant. 2000;26:511–16.CrossRefGoogle ScholarPubMed
Medd, PG, Peniket, AJ, Littlewood, TJ, Pearce, R, Perry, J, Kirkland, KE et al; British Society of Blood and Marrow Transplantation. Evidence for a GVL effect following reduced-intensity allo-SCT in ALL: a British Society of Blood and Marrow Transplantation study. Bone Marrow Transplant. 2013;48(7):982–7.Google ScholarPubMed
van de Donk, NW, Kröger, N, Hegenbart, U, Corradini, P, San Miguel, JF, Goldschmidt, H, et al. Prognostic factors for donor lymphocyte infusions following non-myeloablative allogeneic stem cell transplantation in multiple myeloma. Bone Marrow Transplant. 2006;37(12):1135–41.CrossRefGoogle ScholarPubMed
Stern, M, de Wreede, LC, Brand, R, van Biezen, A, Dreger, P, Mohty, M, et al. Sensitivity of hematological malignancies to graft-versus-host effects: an EBMT megafile analysis. Leukemia. 2014; Apr 30. [Epub ahead of print]CrossRefGoogle Scholar
Tyler, EM, Jungbluth, AA, O’Reilly, RJ, Koehne, G. WT1-specific T-cell responses in high-risk multiple myeloma patients undergoing allogeneic T cell-depleted hematopoietic stem cell transplantation and donor lymphocyte infusions. Blood. 2013;121(2):308–17.CrossRefGoogle ScholarPubMed
Cooper, N., Rao, K., Goulden, N., Amrolia, P. and Veys, P. Alpha interferon augments the graft-versus-leukaemia effect of second stem cell transplants and donor lymphocyte infusions in high-risk paediatric leukaemias. Br J Haematol. 2012;156:550–2.CrossRefGoogle ScholarPubMed
El-Cheikh, J, Crocchiolo, R, Furst, S, Ladaique, P, Castagna, L, Faucher, C, et al. Lenalidomide plus donor-lymphocytes infusion after allogeneic stem-cell transplantation with reduced-intensity conditioning in patients with high-risk multiple myeloma. Exp Hematol. 2012;40(7):521–7.CrossRefGoogle ScholarPubMed
Rizzieri, DA, Storms, R, Chen, DF, Long, G, Yang, Y, Nikcevich, DA et al. Natural killer cell-enriched donor lymphocyte infusions from A 3–6/6 HLA-matched family member following nonmyeloablative allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2010;16(8):1107–14.CrossRefGoogle ScholarPubMed
Ho, VT, Kim, HT, Kao, G, Cutler, C, Levine, J, Rosenblatt, J, et al. Sequential infusion of donor-derived dendritic cells with donor lymphocyte infusion for relapsed hematologic cancers after allogeneic hematopoietic stem cell transplantation. Am J Hematol. 2014; Aug 13. [Epub ahead of print]CrossRefGoogle Scholar
Wagner, E, Wehler, D, Kolbe, K, Theobald, M, Herr, W and Meyer, R. Impact of Prophylactic CD8-Depleted Donor-Lymphocyte Infusions After Allogeneic Hematopoietic Stem Cell Transplantation and Alemtuzumab Mediated T-Cell Depletion. Abstract 4109. American Society of Hematology Annual Meeting 2013.CrossRefGoogle Scholar
Samarasinghe, S, Mancao, C, Pule, M, Nawroly, N, Karlsson, H, Brewin, J, et al. Functional characterization of alloreactive T cells identifies CD25 and CD71 as optimal targets for a clinically applicable allodepletion strategy. Blood. 2010;115(2):396407.CrossRefGoogle ScholarPubMed
Solomon, SR, Mielke, S, Savani, BN, Montero, A, Wisch, L, Childs, R, et al. Selective depletion of alloreactive donor lymphocytes: a novel method to reduce the severity of graft-versus-host disease in older patients undergoing matched sibling donor stem cell transplantation. Blood. 2005;106(3):1123–9. Epub 2005 Apr 7.CrossRefGoogle ScholarPubMed
Ciceri, F, Bonini, C, Marktel, S, Zappone, E, Servida, P, Bernadi, M et al. Anti-tumor effect of HSV-TK engineered donor lymphocytes after allogeneic stem cell transplantation. Blood. 2007;109:4698–707.CrossRefGoogle Scholar
Ciceri, F, Lupo-Stanghellini, M, Oliveira, G, Greco, R et al. Long-term safety and survival outcomes after TK-expressing donor lymphocyte infusion (TK-DLI) in allogeneic hematopoietic stem cell transplantation (HSCT).J Clin Oncol. 2013;31(Suppl): abstr 7007.CrossRefGoogle Scholar
Di Stasi, A, Tey, SK, Dotti, G, Fujita, Y, Kennedy-Nasser, A, Martinez, C, Vago, L, Bondanzo, A et al. Inducible apoptosis as a safety switch for adoptive cell therapy. N Engl J Med. 2011;365(18):1673–83.CrossRefGoogle ScholarPubMed

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