Book contents
- Frontmatter
- Contents
- List of contributors
- Part I Introduction
- Part II Organization of neuronal activity in neuronal populations
- Part III Neuronal population information coding and plasticity in specific brain areas
- Part IV Functional integration of different brain areas in information processing and plasticity
- Part V Disturbances of population activity as the basis of schizophrenia
- 16 Neural coordination and psychotic disorganization
- 17 The role of synchronous gamma-band activity in schizophrenia
- Part VI Summary, conclusion, and future targets
- Index
- References
16 - Neural coordination and psychotic disorganization
Published online by Cambridge University Press: 14 August 2009
Book contents
- Frontmatter
- Contents
- List of contributors
- Part I Introduction
- Part II Organization of neuronal activity in neuronal populations
- Part III Neuronal population information coding and plasticity in specific brain areas
- Part IV Functional integration of different brain areas in information processing and plasticity
- Part V Disturbances of population activity as the basis of schizophrenia
- 16 Neural coordination and psychotic disorganization
- 17 The role of synchronous gamma-band activity in schizophrenia
- Part VI Summary, conclusion, and future targets
- Index
- References
Summary
Introduction
I am trying to understand how ideas and concepts are generated and manipulated in networks of neurons; I want to understand how we think. You probably share my curiosity and believe that the human brain creates and processes mental objects like the ideas and concepts that make up thoughts. We probably also agree that a key to understanding these mental processes is to understand how neurons represent abstract information.
It is less certain we agree on what to do to discover how neurons represent this sort of information. While I suspect we will get quite far by studying mental processes in animals, I admit that I don't know whether or not animals have ideas, concepts, and thoughts. Such open questions do not invalidate the quest to understand thought because the pursuit is founded on the conviction that mental objects are properties of neural systems and that the neural systems in the human brain are fundamentally similar to the systems in the fascinating brains of lower mammals like the laboratory rat. If we restrict the discussion to the non-moral question of how neurons give rise to thought, then the question of animal mentalism need not be asked, because the answer is not important for directing a rigorous scientific effort to understand the neurophysiology of thought.
- Type
- Chapter
- Information
- Information Processing by Neuronal Populations , pp. 387 - 408Publisher: Cambridge University PressPrint publication year: 2008
References
(1972). Single units and sensation: a neuron doctrine for perceptual psychology?Perception 1:371–394.CrossRefGoogle ScholarPubMed
and (1993). A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31–39.CrossRefGoogle ScholarPubMed
and (1973). Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol (Lond) 232:331–356.CrossRefGoogle ScholarPubMed
, , , , and (1998). A statistical paradigm for neural spike train decoding applied to position prediction from ensemble firing patterns of rat hippocampal place cells. J Neurosci 18:7411–7425.CrossRefGoogle ScholarPubMed
, , , et al. (1997). Dissociation of exteroceptive and idiothetic orientation cues: effect on hippocampal place cells and place navigation. Phil Trans R SocLond B 352:1515–1524.CrossRefGoogle ScholarPubMed
and (1981). Commissural and perforant path interactions in the rat hippocampus: field potentials and unitary activity. Exp Brain Res 43:429–438.Google ScholarPubMed
and (1981). Commissural projection to the dentate gyrus of the rat: evidence for feed-forward inhibition. Brain Res 230:346–350.CrossRefGoogle ScholarPubMed
, , , et al. (2002). Homeostatic maintenance of neuronal excitability by burst discharges in vivo. Cereb Cortex 12:893–899.CrossRefGoogle ScholarPubMed
, , , and (2001). Inactivating one hippocampus impairs avoidance of a stable room-defined place during dissociation of arena cues from room cues by rotation of the arena. Proc Natl Acad Sci USA 98:3531–3536.CrossRefGoogle ScholarPubMed
and (2006). Temporal encoding of place sequences by hippocampal cell assemblies. Neuron 50:145–157.CrossRefGoogle ScholarPubMed
and (2001). Temporal binding and the neural correlates of sensory awareness. Trends Cogn Sci 5:16–25.CrossRefGoogle ScholarPubMed
, , and (1999). Anaesthetic/amnesic agents disrupt beta frequency oscillations associated with potentiation of excitatory synaptic potentials in the rat hippocampal slice. Br J Pharmacol 128:1813–1825.CrossRefGoogle ScholarPubMed
and (1993). Place navigation in rats with unilateral tetrodotoxin inactivation of the dorsal hippocampus: place but not procedural learning can be lateralized to one hippocampus. Behav Neurosci 107:552–564.CrossRefGoogle Scholar
and (2003). Navigation in the moving world. In: The Neurobiology of Spatial Behaviour, ed. Oxford, UK: Oxford University Press.Google Scholar
and (2006). The discharge of hippocampal place cells with overlapping firing fields is coordinated on the timescale of seconds. Soci Neurosci Abstr 36:211.09.Google Scholar
and (1998). Place cell discharge is extremely variable during individual passes of the rat through the firing field. Proc Natl Acad Sci USA 95:3182–3187.CrossRefGoogle ScholarPubMed
, , , and (1995). Interhippocampal synthesis of lateralized place navigation engrams. Hippocampus 5:16–24.CrossRefGoogle ScholarPubMed
, , , and (1998). Both here and there: simultaneous expression of autonomous spatial memories. Proc Natl Acad Sci USA 95:11 493–11 498.CrossRefGoogle ScholarPubMed
, , and . (2006). Phencyclidine impairs cognition if and only if it co-activates initially independently active neurons. Soc Biol Psychiatry Meeting Abstract1477.Google Scholar
, , and , Jr. (1986). Hippocampal theta rhythm and the firing of neurons in walking and urethane anesthetized rats. Exp Brain Res 50:210–220.Google Scholar
, , , et al. (1999). Cerebral microdialysis combined with single neuron and EEG recording in neurosurgical patients. J Neurosurg 91:697–705.CrossRefGoogle ScholarPubMed
, , , and (1999). Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles. Nat Neurosci 2:1120–1124.CrossRefGoogle ScholarPubMed
, , , and (1983). Estrogenic maintenance of lordotic responsiveness: requirement for hypothalamic action potentials. Brain Res 268:67–78.CrossRefGoogle ScholarPubMed
, , , , and (2003). Organization of cell assemblies in the hippocampus. Nature 424:552–556.CrossRefGoogle ScholarPubMed
(1987). Computer simulations of neural information processing and the schizophrenia–mania dichotomy. Arch Gen Psychiat 44:178–188.CrossRefGoogle ScholarPubMed
(2005). Extracellular diffusion is fast and isotropic in the stratum radiatum of hippocampal CA1 region in rat brain slices. Hippocampus 15:441–450.CrossRefGoogle ScholarPubMed
and (2006). Temporal coordination of hippocampal discharge during foraging in two continuously dissociated spaces. Soc Neurosci Abstr 36:211.12.Google Scholar
, , , , and (2004). Increased attention to spatial context increases both place field stability and spatial memory. Neuron 42:283–295.CrossRefGoogle ScholarPubMed
, , , et al. (2003). Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo. Nature 421:844–848.CrossRefGoogle ScholarPubMed
, , and (2005). Tetrodotoxin infusions into the dorsal hippocampus block non-locomotor place recognition. Hippocampus 15:460–471.CrossRefGoogle ScholarPubMed
(1948). Conditioned Reflexes and Neuron Organization. Cambridge, UK: Cambridge University Press.Google Scholar
and (2005). Behavioral evidence that segregation and representation are dissociable hippocampal functions. J Neurosci 25:9205–9212.CrossRefGoogle ScholarPubMed
and (2002). Disruption of prepulse inhibition of startle reflex in a neurodevelopmental model of schizophrenia: reversal by clozapine, olanzapine and risperidone but not by haloperidol. Neuropsychopharmacology 27:1–11.CrossRefGoogle Scholar
, , , , and (2002). Long-term plasticity in hippocampal place cells representation of environmental geometry. Nature 416:90–94.CrossRefGoogle ScholarPubMed
, , , et al. (2002). Protein kinase M zeta is necessary and sufficient for LTP maintenance. Nat Neurosci 5:295–296.CrossRefGoogle Scholar
and , (2000). To model a psychiatric disorder in animals: schizophrenia as a reality test. Neuropsychopharmacology 23:223–239.CrossRefGoogle Scholar
, , , , and (1992). Ibotenic acid lesion of the ventral hippocampus differentially affects dopamine and its metabolites in the nucleus accumbens and prefrontal cortex in the rat. Brain Res 585:1–6.CrossRefGoogle ScholarPubMed
, , and (1993). Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal hippocampal damage: a potential animal model of schizophrenia. Neuropsychopharmacology 9:67–75.CrossRefGoogle ScholarPubMed
, , , , and (2002). Neonatal damage of the ventral hippocampus impairs working memory in the rat. Neuropsychopharmacology 27:47–54.CrossRefGoogle ScholarPubMed
and (1987). The effects of changes in the environment on the spatial firing of hippocampal complex-spike cells. J Neurosci 7:1951–1968.CrossRefGoogle ScholarPubMed
(1976). Place units in the hippocampus of the freely moving rat. Exp Neurol 51:78–109.CrossRefGoogle ScholarPubMed
, , and (2002). Properties of the extra-positional signal in hippocampal place cell discharge derived from the overdispersion in location-specific firing. Neuroscience 111:553–656.CrossRefGoogle ScholarPubMed
, , and (2006). Cognitive disorganization in hippocampus: a physiological model of the disorganization in psychosis. J Neurosci 26:158–168.CrossRefGoogle ScholarPubMed
, , , et al. (2006). Storage of spatial information by the maintenance mechanism of LTP. Science 313:1141–1144.CrossRefGoogle ScholarPubMed
and (2003). Convergence of biological and psychological perspectives on cognitive coordination in schizophrenia. Behav Brain Sci 26:65–82; discussion 82–137.CrossRefGoogle Scholar
and (1997). In search of common foundations for cortical computation. Behav Brain Sci 20:657–683; discussion 683–722.CrossRefGoogle ScholarPubMed
, , and (1997). Neonatal lesions of the rat ventral hippocampus result in hyperlocomotion and deficits in social behaviour in adulthood. Psychopharmacology 132:303–310.CrossRefGoogle ScholarPubMed
, 2nd, , and (2006). Weak pairwise correlations imply strongly correlated network states in a neural population. Nature 440:1007–1012.CrossRefGoogle Scholar
, , , et al. (2004). Neural synchrony indexes disordered perception and cognition in schizophrenia. Proc Natl Acad Sci USA 101:17 288–17 293.CrossRefGoogle ScholarPubMed
, , and (1983). A behavioural analysis of spatial localization following electrolytic, kainate- or colchicine-induced damage to the hippocampal formation in the rat. Behavioral. Brain Res 7:133–153.Google ScholarPubMed
and (2000). Schizophrenia and the mechanisms of conscious integration. Brain Res Brain Res Rev 31:391–400.CrossRefGoogle ScholarPubMed
and (2006). Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology. Neuron 52:155–168.CrossRefGoogle ScholarPubMed
(2001). The hippocampus as an olfacto-motor mechanism: were the classical anatomists right after all?Behav Brain Res 127:25–47.CrossRefGoogle Scholar
and (1994). The behavioral neurobiology of learning and memory: a conceptual reorientation. Brain Res Brain Res Rev 19:264–297.CrossRefGoogle ScholarPubMed
(1981). The Correlation Theory of Brain Function, Technical Report 81–2. Frankfunt, Germany: Biophysical Chemistry, Max Planck Institute.Google Scholar
, , and (2002). Rats can track odors, other rats, and themselves: implications for the study of spatial behavior. Behav Brain Res 131:185–192.CrossRefGoogle Scholar
, , and . (2005). Beyond memory, navigation and inhibition: behavioural evidence for hippocampus-dependent cognitive coordination in the rat. J Neurosci 25:2413–2419.CrossRefGoogle ScholarPubMed
and (1993). Dynamics of the hippocampal ensemble code for space. Science 261:1055–1058.CrossRefGoogle ScholarPubMed
and (1991). Extent of the tetrodotoxin induced blockade examined by pupillary paralysis elicited by intracerebral injection of the drug. Exp Brain Res 83:687–690.CrossRefGoogle ScholarPubMed
, , , , and (2000). Understanding hippocampal activity using purposeful behavior: place navigation induces place cell discharge in both the task-relevant and task-irrelevant spatial reference frames. Proc Natl Acad Sci USA 97:3771–3776.CrossRefGoogle ScholarPubMed
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