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Chapter 27 - Cannabis Withdrawal

from Part VIII - Special Topics

Published online by Cambridge University Press:  12 May 2023

By
Jane Metrik  and
Kayleigh N. McCarty
Edited by
Deepak Cyril D'Souza ,
David Castle  and
Sir Robin Murray
Deepak Cyril D'Souza
Affiliation:
Staff Psychiatrist, VA Connecticut Healthcare System; Professor of Psychiatry, Yale University School of Medicine
David Castle
Affiliation:
University of Tasmania, Australia
Sir Robin Murray
Affiliation:
Honorary Consultant Psychiatrist, Psychosis Service at the South London and Maudsley NHS Trust; Professor of Psychiatric Research at the Institute of Psychiatry
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Summary

Abrupt cessation of chronic and frequent cannabis use is associated with cannabis withdrawal. Cannabis withdrawal syndrome is a clinically significant diagnosis and a criterion of cannabis use disorder (CUD) marked by mood and sleep disturbance symptoms, appetite and/or weight loss and restlessness, and physical symptoms such as abdominal pain, shakiness/tremors, sweating, fever, chills and headaches. The goal of this chapter is to fully characterize the clinical significance, time course, neurological mechanisms and treatment of cannabis withdrawal. The chapter synthesizes studies examining individual difference factors (demographics, cannabis use patterns, genetics and heritability and psychiatric comorbidity) that place some people at disproportionally higher risk for cannabis withdrawal or greater severity of symptoms. The cyclical nature of resuming use due to the inability to cope with the distress of cannabis withdrawal is negatively reinforcing and presents major challenges to individuals trying to abstain from problematic cannabis use. Implications for evidence-based strategies that can help mitigate the psychological and physiological symptoms of cannabis withdrawal are discussed.

Keywords

cannabis withdrawalTHCcannabis use disordercessationtreatmentmoodsleep
Type
Chapter
Information
Marijuana and Madness , pp. 285 - 298
Publisher: Cambridge University Press
Print publication year: 2023

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  • Cannabis Withdrawal
  • Edited by Deepak Cyril D'Souza, Staff Psychiatrist, VA Connecticut Healthcare System; Professor of Psychiatry, Yale University School of Medicine, David Castle, University of Tasmania, Australia, Sir Robin Murray, Honorary Consultant Psychiatrist, Psychosis Service at the South London and Maudsley NHS Trust; Professor of Psychiatric Research at the Institute of Psychiatry
  • Book: Marijuana and Madness
  • Online publication: 12 May 2023
  • Chapter DOI: https://doi.org/10.1017/9781108943246.028
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  • Cannabis Withdrawal
  • Edited by Deepak Cyril D'Souza, Staff Psychiatrist, VA Connecticut Healthcare System; Professor of Psychiatry, Yale University School of Medicine, David Castle, University of Tasmania, Australia, Sir Robin Murray, Honorary Consultant Psychiatrist, Psychosis Service at the South London and Maudsley NHS Trust; Professor of Psychiatric Research at the Institute of Psychiatry
  • Book: Marijuana and Madness
  • Online publication: 12 May 2023
  • Chapter DOI: https://doi.org/10.1017/9781108943246.028
Available formats
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  • Cannabis Withdrawal
  • Edited by Deepak Cyril D'Souza, Staff Psychiatrist, VA Connecticut Healthcare System; Professor of Psychiatry, Yale University School of Medicine, David Castle, University of Tasmania, Australia, Sir Robin Murray, Honorary Consultant Psychiatrist, Psychosis Service at the South London and Maudsley NHS Trust; Professor of Psychiatric Research at the Institute of Psychiatry
  • Book: Marijuana and Madness
  • Online publication: 12 May 2023
  • Chapter DOI: https://doi.org/10.1017/9781108943246.028
Available formats
×