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Selegiline

Published online by Cambridge University Press:  20 February 2025

K. Ray Chaudhuri
Affiliation:
King's College London
Peter Jenner
Affiliation:
King's College London
Valentina Leta
Affiliation:
King's College London
Shelley Jones
Affiliation:
King's College London
Iro Boura
Affiliation:
St. George General Hospital of Chania, Crete, Greece
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Summary

Selegiline hydrochloride ((R)-(–)-N,α-dimethyl-N-2-propynylphenethylamine hydrochloride) and commonly referred to as l-deprenyl, is a white to near-white crystalline powder, freely soluble in water, with a molecular weight of 223.75 and an empirical formula of C13H17N•HCl.

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Publisher: Cambridge University Press
Print publication year: 2025

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References

Suggested Reading

Cereda, E, Cilia, R, Canesi, M, Tesei, S, Mariani, CB, Zecchinelli, AL, Pezzoli, G. Efficacy of rasagiline and selegiline in Parkinson’s disease: a head-to-head 3-year retrospective case-control study. J Neurol 2017; 264(6): 12541263.CrossRefGoogle ScholarPubMed
Fabbrini, G, Abbruzzese, G, Marconi, S, Zappia, M. Selegiline: a reappraisal of its role in Parkinson disease. Clin Neuropharmacol 2012; 35(3): 134140.CrossRefGoogle ScholarPubMed
Mizuno, Y, Hattori, N, Kondo, T, Nomoto, M, Origasa, H, Takahashi, R, Yamamoto, M, Yanagisawa, N. Long-term selegiline monotherapy for the treatment of early Parkinson disease. Clin Neuropharmacol 2019; 42(4): 123130.CrossRefGoogle ScholarPubMed
Tan, Y-Y, Jenner, P, Chen, S-D. Monoamine oxidase-B inhibitors for the treatment of Parkinson’s disease: past, present, and future. J Parkinsons Dis 2022; 12(2): 477493.CrossRefGoogle ScholarPubMed

References

AHFS Drug information, 2012. Bethesda: American Society of Health-System Pharmacists. Accessed on 15 May 2022 via www.medicinescomplete.com.Google Scholar
Binde, CD, Tvete, IF, Gåsemyr, JI, Natvig, B, M Klemp, . Comparative effectiveness of dopamine agonists and monoamine oxidase type-B inhibitors for Parkinson’s disease: a multiple treatment comparison meta-analysis. Eur J Clin Pharmacol 2020; 76(12): 17311743.CrossRefGoogle ScholarPubMed
Deleu, D, Northway, MG, Hanssens, Y. Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson’s disease. Clin Pharmacokinet 2002; 41(4): 261309.CrossRefGoogle ScholarPubMed
Joint Formulary Committee. British National Formulary (online). London: BMJ Group and Pharmaceutical Press. Accessed on 15 May 2022 via www.medicinescomplete.com.Google Scholar
Koschel, J, Chaudhuri, KR, Tönges, L, Thiel, M, Raeder, V, Jost, WH. Implications of dopaminergic medication withdrawal in Parkinson’s disease. J Neural Transm (Vienna), 2022; 129(9): 11691178.CrossRefGoogle ScholarPubMed
Laine, K, Anttila, M, Huopponen, R, Mäki-Ikola, O, Heinonen, E. Multiple-dose pharmacokinetics of selegiline and desmethylselegiline suggest saturable tissue binding. Clin Neuropharmacol 2000; 23(1): 2227.CrossRefGoogle ScholarPubMed
Nagatsu, T, Sawada, M. Molecular mechanism of the relation of monoamine oxidase B and its inhibitors to Parkinson’s disease: possible implications of glial cells. J Neural Transm Suppl 2006; 2006(71): 5365.Google Scholar
Selegiline. In: Brayfield, A (Ed.), Martindale: The Complete Drug Reference. London: The Royal Pharmaceutical Society of Great Britain. Accessed on 15 May 2022 via www.medicinescomplete.com.Google Scholar
Summary of product characteristics – Eldepryl 10 m tablets. Orion Pharma (UK) Ltd. Electronic Medicines Compendium: Eldepryl 10mg tablets – summary of product characteristics (SmPC) – (emc). Accessed on 15 May 2022 via www.medicines.org.uk.Google Scholar
Tábi, T, Szöko˝, E, Vécsei, L, Magyar, K. The pharmacokinetic evaluation of selegiline ODT for the treatment of Parkinson’s disease. Expert Opin Drug Metab Toxicol 2013; 9(5): 629636.CrossRefGoogle ScholarPubMed

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  • Selegiline
  • K. Ray Chaudhuri, King's College London, Peter Jenner, King's College London, Valentina Leta, King's College London, Shelley Jones, King's College London, Iro Boura, St. George General Hospital of Chania, Crete, Greece
  • Book: The Movement Disorders Prescriber's Guide to Parkinson's Disease
  • Online publication: 20 February 2025
  • Chapter DOI: https://doi.org/10.1017/9781009222648.046
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  • Selegiline
  • K. Ray Chaudhuri, King's College London, Peter Jenner, King's College London, Valentina Leta, King's College London, Shelley Jones, King's College London, Iro Boura, St. George General Hospital of Chania, Crete, Greece
  • Book: The Movement Disorders Prescriber's Guide to Parkinson's Disease
  • Online publication: 20 February 2025
  • Chapter DOI: https://doi.org/10.1017/9781009222648.046
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Selegiline
  • K. Ray Chaudhuri, King's College London, Peter Jenner, King's College London, Valentina Leta, King's College London, Shelley Jones, King's College London, Iro Boura, St. George General Hospital of Chania, Crete, Greece
  • Book: The Movement Disorders Prescriber's Guide to Parkinson's Disease
  • Online publication: 20 February 2025
  • Chapter DOI: https://doi.org/10.1017/9781009222648.046
Available formats
×