Published online by Cambridge University Press: 28 January 2023
Premature Ovarian Insufficiency (POI) is defined by follicular depletion that occurs under the age of 40 and is characterised by a gradual fall of hormone production by the ovary, leading to amenorrhoea and infertility. The hallmark for diagnosis is raised follicular stimulating hormone (FSH) above 25 IU/L measured twice, at least 4 weeks apart.
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