Book contents
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Approach to Autopsy of the Perinatal Nervous System
- Ancillary Studies
- Prosection Techniques
- Chapter 9 Brain Prosection
- Chapter 10 Spinal Cord Prosection
- Chapter 11 Neuromuscular Specimens
- Chapter 12 Eye Specimens
- Tissue Selection
- Reporting
- Section 2 Human Nervous System Development
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Section 5 Malformations
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Chapter 11 - Neuromuscular Specimens
from Prosection Techniques
Published online by Cambridge University Press: 07 August 2021
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Approach to Autopsy of the Perinatal Nervous System
- Ancillary Studies
- Prosection Techniques
- Chapter 9 Brain Prosection
- Chapter 10 Spinal Cord Prosection
- Chapter 11 Neuromuscular Specimens
- Chapter 12 Eye Specimens
- Tissue Selection
- Reporting
- Section 2 Human Nervous System Development
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Section 5 Malformations
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Summary
In a routine practice, neuromuscular specimens obtained by biopsy may be analyzed by light and electron microscopy, including enzyme histochemistry, as well as by molecular and biochemical procedures. In all cases, neuromuscular biopsy must be correlated with patient’s clinical history and current neuromuscular exam, including electro-diagnostic findings. Handling of tissue obtained by neuromuscular biopsy is critical for a successful pathological analysis, and thus triaging, orienting, snap-freezing and preserving of specimens need to be clearly specified and performed with great care [1, 2, 3]. In this chapter, we describe recommended steps and procedures for the handling of neuromuscular biopsy specimens in preparation for gross and histopathological analyses, including tips for preventing common artifacts (e.g., formation of ice crystals).
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- Information
- Perinatal Neuropathology , pp. 53 - 55Publisher: Cambridge University PressPrint publication year: 2021