Book contents
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Section 2 Human Nervous System Development
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Cellular Responses
- Gray Matter
- White Matter
- Chapter 34 Periventricular Leukomalacia and Diffuse White Matter Injury
- Germinal Matrix
- Cerebellum
- Section 5 Malformations
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Chapter 34 - Periventricular Leukomalacia and Diffuse White Matter Injury
from White Matter
Published online by Cambridge University Press: 07 August 2021
Book contents
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Section 2 Human Nervous System Development
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Cellular Responses
- Gray Matter
- White Matter
- Chapter 34 Periventricular Leukomalacia and Diffuse White Matter Injury
- Germinal Matrix
- Cerebellum
- Section 5 Malformations
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Summary
Cerebral white matter lesions seen in the perinatal period include periventricular leukomalacia (PVL), historically defined as focal white matter necrosis, and diffuse cerebral white matter gliosis (DWMG), with which PVL is nearly always associated. The first use of the term PVL was by Banker and Larroche in 1962, although the gross and microscopic features had been noted by others (reviewed in Haynes and Folkerth, 2018 [1]). More recently, the broader terms white matter injury (WMI) or diffuse white matter injury (DWMI) have been in use, in part because it refers to the increasingly more common pattern of DWMG, with or without microscopic necroses, reflecting the trend toward decreasing macroscopically visible (or sonographically detectable) “cystic” lesions. This decrease in perinatal brain injury is in turn attributed to improvements in supportive care of preterm neonates, at especial risk for fluctuations of blood pressure (and often cerebral perfusion pressure), and respiration/oxygenation [2].
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- Information
- Perinatal Neuropathology , pp. 183 - 192Publisher: Cambridge University PressPrint publication year: 2021
References
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