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Chapter 2 - From Psychoneuroimmunology to Immunopsychiatry: An Historical Perspective

Published online by Cambridge University Press:  02 September 2021

By
Keith W. Kelley
Edited by
Golam Khandaker ,
Neil Harrison ,
Edward Bullmore  and
Robert Dantzer
Golam Khandaker
Affiliation:
University of Cambridge
Neil Harrison
Affiliation:
Cardiff University Brain Research Imaging Centre (CUBRIC)
Edward Bullmore
Affiliation:
University of Cambridge
Robert Dantzer
Affiliation:
University of Texas, MD Anderson Cancer Center
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Summary

      It was the best of times, it was the worst of times,
      it was the age of wisdom, it was the age of foolishness,
      it was the epoch of belief, it was the epoch of incredulity,
      it was the season of Light, it was the season of Darkness,
      it was the spring of hope, it was the winter of despair …
    Charles Dickens, A Tale of Two Cities, 1859
Following Great Britain’s loss of the American Revolutionary War in 1783, the industrial revolution continued to prop up King George III in London. In Paris, the other major city in Dickens’ novel, it was the best of times for King Louis XVI and his queen, Marie Antoinette. They had a palace at Versailles and enormous wealth. But it soon become the worst of times for them and other bourgeoisie with the beginning of the French Revolution in 1789 and continuing through the Reign of Terror that ended in 1794. Nearly two centuries later in 1989, it was worst of times for the fledging field of psychoneuroimmunology (PNI). But now it is the best of times for this field that emphasizes an integrative physiological approach to biomedical research. This renaissance in PNI has laid a solid brick-and-mortar foundation for the emerging field of immunopsychiatry. Indeed, before one can understand the importance of the emerging field of immunopsychiatry, one must first grasp the historical developments of PNI. The best and worst of times for immunopsychiatry has yet to be written. Laissez les bon temps rouler!

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Chapter
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Textbook of Immunopsychiatry , pp. 25 - 50
Publisher: Cambridge University Press
Print publication year: 2021

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