As we move from Scotus into what is more normally thought of as the early modern period, we will notice five destructive approaches to the Mainline Tradition – often originally developed in more or less separate interests. The first tends to subordinate the search for virtue to the supposedly more basic search for human rights; the second minimizes or eliminates the effects of original sin; the third replaces the concept of soul, with its Christian implications, by that of mind or ‘self’; the fourth limits or eliminates the role of God in human affairs; the fifth moves from discovering and respecting nature’s ‘laws’ to denying final causes and seeking to master the physical universe.