Understanding the correlation between genes and diet holds significance in formulating tailored nutritional guidance and enhancing public health initiatives. Consequently, a thorough examination is undertaken to clarify the interplay between varying nutrient intake, Glutathione S-transferases Mu1 and Theta 1 (GSTM1 & T1) gene variants, and susceptibility to cancer development. In this study, we conducted a comprehensive search on MEDLINE/PubMed, Scopus, and Web of Science databases up to April 30, 2023. The review included observational studies that explored the relationship between dietary consumption of acrylamide, fruits, vegetables, plant-based foods, total meat, red meat, coffee, and green tea, as well as the presence of GSTM1 and T1 gene polymorphisms, and the risk of cancer in adult populations. The review findings indicated that high levels of risk factors, particularly red meat, have been linked to a higher chance of developing colorectal cancer risk among individuals with the GSTM1 null genotype. In contrast, heightened levels of protective factors, such as cruciferous vegetables, green tea, coffee, and fruit, have been associated with a decreased risk of lung cancer, adult leukemia, cutaneous melanoma, and lung cancer in individuals exhibiting GST polymorphisms. There is a scarcity of comprehensive studies examining different types of cancer due to various dietary patterns and genetic variations. Research has illuminated the complex interplay among dietary factors, gene polymorphisms, and cancer risk, further comprehensive studies are needed to understand and validate these findings fully. More robust investigations across diverse populations are crucial to developing personalized nutritional interventions and strengthening public health strategies.

Psoriasis is a chronic immune-inflammatory skin disease. Cross-sectional research examining diet quality indices (DQIs) in psoriasis has focused on the Mediterranean diet and is confined to Mediterranean populations, thereby lacking generalisability to other populations. We explored associations between DQIs and the likelihood of reporting a higher psoriasis severity. This was an online cross-sectional study recruiting adult volunteers with psoriasis (n=257). A 147-item food frequency questionnaire evaluated adherence to the Mediterranean Diet Score (MDS), the Dietary Approaches to Stop Hypertension (DASH) score, and the Plant-based Diet Index (PDI); original (oPDI), healthy (hPDI), and unhealthy (uPDI) subtypes. Psoriasis severity was determined with the self-assessed Simplified Psoriasis Index. When adjusted for age, sex, smoking, alcohol over-consumption, energy intake, and psychological morbidity, multinomial logistic regression analyses revealed an increased likelihood of reporting a higher psoriasis severity in participants with a very low adherence to DASH OR = 3.75, 95% CI 1.313 – 10.700, P = 0.01), and hPDI (OR = 4.04, 95% CI 1.251 – 13.064, P = 0.02) patterns. A reduced likelihood of reporting a higher psoriasis severity was shown in participants with low adherence to the uPDI (OR = 0.25, 95% CI 0.085 – 0.716, P = 0.01). With further adjustment for body mass index (BMI), a very low adherence to the oPDI was significantly associated with an increased likelihood of reporting a higher psoriasis severity (OR = 3.46, 95% CI 1.029 – 11.656, P = 0.05). Dietary interventions and assessment should be introduced in the care-pathway for psoriasis management.

Free sugar intakes are currently higher than recommended for health, yet effective strategies for reducing consumption are yet to be elucidated. This work investigated the effects of different dietary recommendations for reducing free sugar intakes, on relevant outcomes, in UK adults consuming >5% total energy intake (TEI) from free sugars. Using a randomized controlled parallel-group design, 242 adults received nutrient-based (N=61), nutrient- and food-based (N=60), nutrient-, food- and food-substitution-based (N=63) or no (N=58) recommendations for reducing free sugars at a single timepoint, with effects assessed for the following 12 weeks. Primary outcomes were free sugar intakes as a percentage of TEI (%FS) and adherence to the recommendations at week 12. Secondary outcomes included TEI, diet composition, sugar-sweetened and low-calorie-sweetened food consumption and anthropometry. In Intention-to-Treat analyses adjusted for baseline measures, %FS reduced in intervention groups (%FSchange=-2.5 to -3.3%) compared to control (%FSchange=-1.2%) (smallest B=-0.573, p=0.03), with effects from week 1 until week 12, and no differences between interventions (largest B=0.352, p=0.42). No effects of intervention were found in dietary profiles, but change in %FS was associated with change in %TEI from non-sugar carbohydrate (B=0.141, p<0.01) and from protein (B=-0.171, p=0.02). Body weight was also lower at week 12 in intervention groups compared to control (B=-0.377, p<0.05), but associations with %FS were weak. Our findings demonstrate benefit from dietary recommendations for reducing free sugar intakes in UK adults. Limited advantages were found for the different dietary recommendations, but variety may offer individual choice.

Trial Registration: Clinicaltrials.gov: NCT04816955, registration date: 24.03.21.

This study aimed to investigate the intake of dairy products during pregnancy in women with gestational diabetes mellitus (GDM), and its impacts on neonatal birth weight and pregnancy outcomes. A total of 386 women with GDM during the second trimester pregnancy participated in this prospective cohort study. We evaluated dairy products intake through Food Frequency Questionnaire. Pregnancy outcomes were obtained from the delivery data. Participants were divided into insufficient and sufficient intake of milk and dairy products group (<300 g/day and ≥300 g/day, respectively). The average intake of dairy products during the second trimester pregnancy in women with GDM was 317.8±179.5 g/day, and the total energy intake was 1635.4±708.7 kcal/day. However, 76.68% of them did not meet the recommended total energy intake of women with GDM. After adjusting for confounding factors, women with GDM who consumed ≥300 g/day of dairy products had an average reduction in birth weight of 93.1 g compared to women who consumed <300 g/day of dairy products (95% CI: -171.343, -14.927). Women with GDM in sufficient intake group was also associated with lower risk of macrosomia (95% CI: 0.043, 0.695) and cesarean section (95% CI: 0.387, 0.933), and not related to low birth weight infant (95% CI: 0.617, 14.502) and preterm birth (95% CI: 0.186, 1.510) when compared with participants in insufficient intake group. Under the premise of insufficient total energy intake, the intake of dairy products during the second trimester pregnancy in women with GDM might be related to the decrease of neonatal birth weight.

Accumulation of exogenous fatty acids such as the long-chain n-11 MUFA cetoleic acid (CA, C22:1n-11) may induce functional changes, through direct effects or by affecting the amounts of other fatty acids through changes in catabolic and anabolic processes including desaturation of fatty acids or by other processes. The primary aim of the present study was to investigate if dietary CA was absorbed and accumulated in a TAG-rich tissue for storage (white adipose tissue), a stable phospholipid-rich tissue (brain), metabolically active tissues (liver and skeletal muscle), or circulating in the blood (blood cells) and metabolised. Secondary aims included to investigate any effects on the levels of EPA and DHA. Eighteen male Zucker Diabetic Sprague Dawley rats were fed diets with herring oil (HERO) containing 0.70 % CA or anchovy oil (ANCO) devoid of CA, or a control diet with soyabean oil for 5 weeks. The HERO and ANCO diets contained 0.35 and 0.37 wt% EPA+DHA, respectively. Data were analysed using one-way ANOVA. CA from dietary HERO was absorbed, and CA and its chain-shortened metabolites were found in blood cells, liver, white adipose tissue and (WAT) and muscle, but n-11 MUFAs were not found in the brain. The concentrations of EPA and DHA were similar in liver lipids (TAG, cholesteryl esters and NEFA) as well as in WAT, muscle and brain from rats fed the HERO or ANCO diets. To conclude, CA was taken up by tissues but did not affect levels of EPA and DHA in this diabetic rat model.

Adolescent girls often skip breakfast due to time constraints and reduced morning appetite. This study examined the acute impact of breakfast consumption timing versus breakfast omission (BO) on glycaemic and insulinaemic responses to lunch in infrequent breakfast-consuming girls. Fifteen girls (13.1±0.8 years) completed three conditions in a randomised crossover design: early-morning breakfast consumption (EM-BC; 8:30), mid-morning breakfast consumption (MM-BC; 10:30), and BO. A standardised lunch was provided at 12:30, followed by a 2-h post-lunch observation period. Blood and expired gas samples were collected periodically. Linear mixed models with Cohen’s d effect sizes compared outcomes between conditions. Pre-lunch glucose and insulin incremental area under the curve (iAUC) were higher in the breakfast conditions versus BO (P≤0.009), with no differences between breakfast conditions. MM-BC reduced post-lunch glucose iAUC by 36% and 25% compared with BO and EM-BC, respectively (P<0.001, d=0.92–1.44). A moderate, non-significant 15% reduction in post-lunch glucose iAUC was seen with EM-BC versus BO (P=0.077, d=0.52). These reductions occurred without changes in post-lunch insulinemia (P≥0.323) and were accompanied by increased post-lunch carbohydrate oxidation compared with BO (P≤0.018, d=0.58–0.75); with no differences between EM-BC and MM-BC. MM-BC lowered glycaemic response over the experimental period compared with BO (P=0.033, d=0.98) and EM-BC (P=0.123, d=0.93), with no difference between EM-BC and BO. Compared with BO, both breakfast conditions lowered post-lunch glycaemic responses with mid-morning breakfast eliciting a greater second-meal effect than early-morning breakfast. These findings indicate the breakfast-to-lunch meal interval may be a crucial factor affecting postprandial glycaemia in infrequent breakfast-consuming girls.

Postpartum maternal diet quality has been linked with optimal infant feeding practices. However, whether maternal diet quality during pregnancy influences infant feeding practices remains unclear. The present study explored the relationship between maternal diet quality in pregnancy and infant feeding practices in Australian women. A brief 15-item food frequency questionnaire was used to collect maternal dietary data (n = 469). Diet quality was calculated using a modified 2013 Dietary Guideline Index (DGI). Multivariable linear and logistic regressions with adjustment for covariates were used to examine associations between maternal diet quality in pregnancy and infant feeding practices: infant feeding mode, breastfeeding duration and timing of solids introduction. Higher DGI score during pregnancy was associated with higher odds of breastfeeding than formula/mixed feeding (adjusted OR 1.03, 95% CI 1.00, 1.07), longer breastfeeding duration (adjusted β 0.09, 95% CI 0.03, 0.15) and higher odds of breastfeeding for ≥6 months (AOR 1.04, 95% CI 1.02, 1.07) than for <6 months. Associations between maternal DGI score and breastfeeding variables were moderated by maternal country of birth, with significant associations observed in Australian-born mothers only. No association was found between maternal DGI score and timing of solids introduction. Higher maternal diet quality was associated with better infant feeding practices, and the association was moderated by country of birth. Our findings provide evidence to support the initiation of dietary interventions to promote diet quality during pregnancy, particularly among Australian-born women. Further research could explore underlying mechanisms linking maternal diet quality and infant feeding practices.

A randomized parallel intervention study was conducted with male patients diagnosed with coronary heart disease. Participants were assigned to three groups: Group A abstained from alcohol (n=20), Group B consumed red wine (n=21) and Group C (n=16) consumed an alcoholic beverage without wine micro-constituents. Biological samples were collected at baseline, 4 and 8 weeks. Enzyme activities of acetyl-CoA:lyso-PAF acetyltransferase (LysoPAF-AT), CDP-choline:1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase (PAF-CPT), PAF-acetylhydrolase (PAF-AH) in leukocyte homogenates, serum lipoprotein associated phospholipase-A2 (LpPLA2) and plasma markers of thrombosis were measured. PAF-, adenosine diphosphate (ADP)-, and collagen- induced platelet aggregation was measured in human platelet rich plasma.

Red wine consumption led to 15.3% reduction in LysoPAF-AT activity at 4 weeks (p=0.008) compared to baseline and Group A (p=0.01). PAF-CPT activity was reduced by 11.1% at 8 weeks (p=0.04) compared to baseline, and by 24.9% compared to Group C (p=0.02). PAF-AH activity was reduced by 36.2% at 8 weeks compared to baseline (p=0.001) and compared to Group A (p<0.000) and Group C (p=0.009). Fibrinogen levels in Group B reduced by 6-9% at 4 (p=0.04) and 8 weeks (p=0.01) compared to baseline while d-dimer in Group C increased by 16.1% at 8 weeks (p=0.005) compared to baseline. Platelet aggregation against PAF and collagen was reduced in Group B (82.6% and 35.4%, respectively), and in Group C (158.4% and 37.1%, respectively) compared to baseline and Group A (p<0.05).

In conclusion, moderate wine consumption improved the activity of PAF-metabolism enzymes regardless of ethanol and reduced platelet aggregation probably through mechanisms different from those of ethanol.

Understanding the determinants of malnutrition is pivotal for public health interventions. This study aimed to identify socio-economic, demographic, dietary, and maternal determinants of wasting and overweight among Brazilian children between 6–59 months. Data from the Brazilian National Survey on Child Nutrition were analyzed (n=11,789). Children’s weight-for height Z scores were calculated according to the WHO growth standard and classified as wasting (Z < -2), normal weight (-2 ≤ Z ≤1), overweight risk (1 < Z ≤ 2), and overweight (Z > 2). Socio-economic, demographic, dietary, and maternal covariables were considered. Adjusted multinomial logistic regression (odds ratio (OR) and 95% confidence interval (95% CI) was employed. The prevalence of overweight and wasting was 9.5% and 2.6%, respectively. In the adjusted model, younger age (6-23 months: OR: 1.7; 95%CI: 1.3; 2.2), consumption of ≥ 5 ultra-processed food groups (OR: 1.8; 95%CI: 1.1; 3.1), maternal underweight (OR: 0.4; 95%CI: 0.2; 0.9), overweight (OR: 1.5; 95%CI: 1.2; 1.9) and mild food insecurity (OR: 0.8; 95%CI: 0.6; 1.0) were associated with child overweight. The Brazilian Northeast (OR: 4.9; 95%CI: 2.1; 11.3), Southeast (OR: 7.1; 95%CI: 3.0; 16.6), South (OR: 4.7; 95%CI: 1.8; 12.1), Midwest regions (OR: 2.7; 95%CI: 1.2; 6.2) and maternal underweight (OR: 5.4; 95%CI: 2.7; 10.7) were associated with wasting. Overweight in Brazil is prevalent among children between 6-59 months, while wasting is not a major public health problem. The main determinants of these Brazilian children's nutritional status were age, ultra-processed food consumption, and maternal nutritional status.

Vitamin K exists naturally in foods as phylloquinone (vitamin K1, PK) and as a range of menaquinones (vitamin K2, MKs). There is scarce information on the occurrence and distribution of PK and MKs in dietary sources, particularly in seafood. This study aimed to comprehensively analyse the contents of vitamin K1, dihydro-K1, and MK-4 to MK-10 in various species, tissue types, and processing degrees of shellfish. Additionally, seasonal differences in the vitamin K content of blue mussels (Mytilus edulis) were explored. Most shellfish products had low contents of total vitamin K (<10 µg/100 g). The highest content of total vitamin K was found in the hepatopancreas of snow crab (170 µg/100 g), the brown meat of brown crab (35 µg/100 g), pre-packaged blue mussels (20 µg/100 g), stuffed brown crab shells (15 µg/100 g), and blue mussels in brine (12 µg/100 g). In general, the hepatopancreas of crustaceans contained considerably higher contents of vitamin K than their white meat counterparts. MKs contributed most to total vitamin K contents, whereas most shellfish products contained low contents of PK, thus making only a minor contribution to the adequate intake (AI) established for adults. No statistically significant differences were observed in PK and MK contents of blue mussels sampled during spring versus late summer (p < 0.005). Nevertheless, a non-significant trend of increasing vitamin K content was observed towards the autumn months. This study presents novel vitamin K data for shellfish, an unexplored food group, and adds to the scarce vitamin K composition data worldwide.

Insulin-like growth factor 1 (IGF-1) is an important growth factor in childhood. We aimed to investigate the impact of food supplements for treatment of moderate acute malnutrition (MAM) on serum IGF-1 (sIGF-1). Secondary analysis of a randomized 2×2×3 factorial nutrition trial was performed. Children aged 6-23 months with MAM received 2093 kJ/day as lipid-based nutrient supplement (LNS) or corn-soy blend (CSB), containing either dehulled soy or soy isolate and different quantities of dried skimmed milk (0%, 20% or 50% of total protein) for 12 weeks. The trial was double-blind with regard to soy and milk, but not to matrix (LNS vs. CSB). sIGF-1 was measured at inclusion and after 12 weeks supplementation. Of 1609 children enrolled, 1455 (90%) had sIGF-1 measured at both time points. During supplementation sIGF-1 increased 6.7 (95%CI 6.1; 7.3) ng/ml compared with an expected age-dependent decrease of 0.3 (95%CI 0.2; 0.4) ng/ml. Children who received LNS vs. CSB had lower increase in sIGF-1 (-8%, 95%CI -12; -3). The effect of LNS was partly attenuated when sIGF-1 was corrected for inflammation. Children who received soy isolate compared with dehulled soy had higher increase in sIGF-1 (6%, 95%CI 1; 12). Milk content did not affect sIGF-1. Overall, sIGF-1 increased during supplementation. The lower increase with LNS vs. CSB was only partly explained by increased inflammation with LNS, and needs further investigation. Isolate vs. dehulled soy led to a higher increase which may be due to antinutrients in dehulled soy.

There is a lack of information from Middle Eastern countries regarding diet-disease associations. We examined dietary glycemic and insulinemic potential in relation to risk of incident diabetes among a large group of Iranian adults. The present study was carried out using data from Yazd Health Study (YaHS)-Taghzieh Mardom Yazd (TAMYZ), a prospective cohort study on adults aged 20 to 70 years in Yazd Greater Area, Iran. This study was initiated in 2014-2016 (baseline examination) and data are collected prospectively at one 5-year intervals. Data on demographic characteristics, dietary intakes, and potential confounders were gathered by interview. During the follow-up phase of the study, diabetes incidence was confirmed by laboratory tests and physician diagnoses. This study included a total of 6178 participants in the cross-sectional analysis and 5105 subjects in the prospective phase. Examining the cross-sectional phase, we failed to find any significant association between dietary glycemic index (GI) and glycemic load (GL) as well as dietary insulin index (DII) or dietary insulin load (DIL) and prevalence of diabetes. No significant relationship was also seen between DII/DIL and risk of T2DM in the prospective phase; however, in the stratified analysis by BMI status, there was an inverse significant association between DII and risk of T2DM (HR for T3 vs. T1: 0.19; 95%CI: 0.04, 0.92; P=0.03) in non-obese (BMI≥25 kg/m2) and overweight (BMI<25 kg/m2)participants. No significant association was found between dietary GI/ dietary GL/ DII/ or DIL with risk of T2DM. More research, particularly with a longer follow-up duration, is needed to confirm these findings.

The influence of appetite and energy intake on energy compensation in response to chronic exercise remains poorly understood. This study examined the temporal impact of habitual exercise on energy intake and the homeostatic appetite regulators that influence energy compensation. Twelve-week-old male Sprague Dawley rats (n=30) fed an AIN-93M diet were randomised into 1 of 3 groups: 1) sedentary control (SED); 2) voluntary wheel exercise (EX); and 3) sedentary, weight-matched to aerobic exercise (SED-WM) for 8 weeks. Measures of energy intake, body weight, and adiposity were assessed. Appetite-regulating hormones acyl-ghrelin, active GLP-1, leptin, and insulin were measured in response to an oral glucose tolerance test. Rats with running wheels completed an average of 192kms over 8 weeks. While energy intake was initially reduced in EX, energy intake gradually increased with exercise training after week 1 (P<0.05). Body weight was lower in EX relative to SED from weeks 3-5, but did not differ at the end of the study. Fat mass and long-term satiety hormones leptin and insulin were lower in EX (P<0.05). No differences were observed in concentrations of the satiety hormone active GLP-1 or the orexigenic hormone acyl-ghrelin. Short-term homeostatic regulators of appetite do not appear to be altered with exercise training. The reduction in adiposity and associated decrease in tonic satiety hormones leptin and insulin are likely contributors to the coupling of energy expenditure with energy intake over time with voluntary exercise.

To assess the therapeutic effects of probiotic oral therapy in pediatric patients with anorexia nervosa and to investigate its impact on intestinal flora composition, brain-gut peptide levels, and overall clinical outcomes. A retrospective study was conducted involving 100 children diagnosed with anorexia nervosa at Xingtang County People’s Hospital between January 2023 and June 2024. Patients were divided into two groups: a control group (n=50) receiving zinc gluconate oral solution alone and an observation group (n=50) receiving zinc gluconate plus probiotics. Outcome measures included intestinal flora analysis, brain-gut peptide levels (SS, NO), clinical efficacy, serum trace element levels (calcium, zinc, iron), and prognosis, including recurrence rates six months post-treatment. Baseline characteristics were similar between the two groups (P>0.05). After treatment, the observation group showed significantly higher levels of Bifidobacterium and Lactobacillus and lower levels of Enterobacter compared to the control group (P<0.05). Additionally, the observation group had lower levels of SS and NO (P<0.05), indicating improved brain-gut communication. Clinical efficacy was significantly higher in the observation group (P<0.05), with improved serum trace element levels (P<0.05 for calcium, zinc, and iron). Furthermore, the recurrence rate six months post-treatment was significantly lower in the observation group compared to the control group (P<0.05). Probiotic supplementation in children with anorexia nervosa effectively modulates intestinal flora, improves brain-gut peptide levels, and enhances clinical outcomes.

This study aimed to investigate the association between family characteristics and adherence to the EAT-Lancet dietary recommendations in 7-year-old children. This is a prospective birth cohort study with 2062 children from Generation XXI (Porto, Portugal), who provided 3-day food diaries at age 7, used to assess habitual food consumption. At the age of 4, maternal diet was assessed using a Food Frequency Questionnaire, and a diet quality score was calculated (higher scores indicating a better maternal diet), and parental-child feeding practices were assessed with the Child-Feeding Questionnaire. Adherence to the EAT-Lancet recommendations was evaluated using the World Index for Sustainability and Health (WISH) at 7, previously adapted to pediatric age. Hierarchical linear regression models (consecutive addition of blocks of variables based on a theoretical framework) were employed to evaluate the associations between family characteristics and adherence to the WISH at age 7 [β regression coefficients and the respective 95% confidence intervals (95%CI)]. Higher maternal age and education at child’s birth were associated with increased adherence to the WISH at age 7 (β=0.018, 95%CI: 0.005, 0.031; β=0.038, 95%CI: 0.024, 0.053, respectively). A better maternal diet quality, and using more restrictive practices on child’s diet, at 4 years old, were both associated with higher scoring in the WISH at 7 years old (β=0.033, 95%CI: 0.018, 0.049; β=0.067, 95%CI: 0.009, 0.125, respectively). Early maternal sociodemographic and diet quality play a significant role in influencing the adherence to a healthy and environmentally sustainable dietary pattern at school-age.

In the last decades, it has been well known that low grade inflammation plays a potential role in the pathogenesis of different cancers. The aim of this systematic review and meta-analysis of observational studies was to evaluate the association between inflammatory potential of diet measured through the Dietary Inflammatory Index (DII), energy-adjusted DII (E-DII), empirical dietary inflammatory pattern (EDIP) and inflammatory score of the diet (ISD) and risk of colorectal cancer (CRC) and site-specific colon cancer. A systematic electronic search of PubMed/Medline, Scopus, the Web of Sciences, and reference lists up to November 21, 2023, was performed. Data were pooled by the generic inverse variance method using random effect model. To assess the heterogeneity of included studies, the I2 index was used. A total of 28 original studies, comprising 2,287,836 participants, were selected to include in this meta-analysis. Pooled results showed a significant association between higher adherence to proinflammatory diet and increased risk of CRC (ES:1.39;95%CI:1.29-1.51;I2=82.9%), colon (ES:1.40;95%CI:1.26-1.55; I²= 73.3%, p<0.01), proximal colon (ES:1.28; 95% CI:1.17-1.40;I²=29.1%), distal (ES:1.50;95%CI:1.30-1.74;I²= 63.5%) and rectal (ES:1.46;95%CI:1.23-1.74;I²=80%). Stratified analysis by type of dietary indices noted that greater adherence to the DII, E-DII, and EDIP were related to significant increase in risk of overall CRC and site-specific colon cancers. Our results highlighted the proposed role of inflammatory protentional of diet as important risk factor for CRC. Adherence to an anti-inflammatory dietary pattern should be recommended to reduce incidence of CRC, globally.

Studies have demonstrated that the quality and transparency of reporting Clinical Practice Guidelines (CPGs) in healthcare are low. This meta-research aimed to evaluate the adherence of nutrition CPGs for critically ill adults to the reporting RIGHT checklist and its association with the methodological quality assessed by AGREE II, along with other potential publication-related factors. A systematic search for CPGs until December 2024 was conducted. RIGHT and AGREE II were applied. Reporting completeness score was created using the data from the evaluations of whether each broken-down item of the RIGHT. Eleven CPGs were identified, none demonstrated adherence greater than 60% to the RIGHT checklist, and the mean of RIGHT score was 33.5±15.5%. There was a strong correlation between the RIGHT score and AGREE II (r=0.886). A development CPGs team including methodologist and/or statistician was associated with a higher RIGHT score (48.9±4.5 versus 27.2±11.0) and it was higher in CPGs recommended or recommended with modifications by AGREE II in comparison to those not recommended (50.1±4.6 versus 37.7±8.1 versus 17.0±6.8), and in those with acceptable and moderate compared to those with low methodological quality (50.1±4.6 versus 32.2±14.5 versus 19.3±6.2). It was also related to the language of publication, being higher in those published in English. The reporting completeness in CPGs for critically ill adults was low, with a strong correlation with the methodological quality. High values of reporting completeness scores were observed between CPGs recommended by AGREE II (with moderate or acceptable quality) and in those including a methodologist/statistician in the development team.