Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-25T22:03:21.394Z Has data issue: false hasContentIssue false
  • English
  • Français

Neuropeptide-like signaling in the microbiota-gut-brain axis

Published online by Cambridge University Press:  15 July 2019

Sergueï O. Fetissov Open the ORCID record for Sergueï O. Fetissov [Opens in a new window]
Sergueï O. Fetissov*
Affiliation:
Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Inserm UMR1239, University of Rouen Normandy, Institute for Research and Innovation in Biomedicine (IRIB), 76130 Mont-Saint-Aignan, France. Serguei.Fetissov@univ-rouen.fr
Get access Rights & Permissions [Opens in a new window]

Abstract

For gut microbiota to influence behavior, microorganisms should be able to interfere with specific brain neurochemical circuitries. Understanding these molecular mechanisms is a key task in the new microbiota-gut-brain field. Recent studies have revealed that one major mechanistic link is the modulation of neuropeptide signaling by homologous bacterial proteins acting both directly and indirectly via production of neuropeptide-reactive immunoglobulins.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 42 , 2019 , e70
Check for updates
Copyright
Copyright © Cambridge University Press 2019 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

1.

The author is a founder and scientific advisor of TargEDys SA.

References

Breton, J., Legrand, R., Akkermann, K., Järv, A., Harro, J., Déchelotte, P. & Fetissov, S. O. (2016a) Elevated plasma concentrations of bacterial ClpB protein in patients with eating disorders. International Journal of Eating Disorders 49(8):805–808. Available at: https://www.doi.org/10.1002/eat.22531.Google Scholar
Breton, J., Tennoune, N., Lucas, N., François, M., Legrand, R., Jacquemot, J., Goichon, A., Guérin, C., Peltier, J., Pestel-Caron, M., Chan, P., Vaudry, D., do Rego, J. C., Liénard, F., Pénicaud, J., Fioramonti, X., Ebenezer, I. S, Hökfelt, T., Déchelotte, P. & Fetissov, S. O. (2016b) Gut commensal E. coli proteins activate host satiety pathways following nutrient-induced bacterial growth. Cell Metabolism 23:324–34. Available at: http://dx.doi.org/10.1016/j.cmet.2015.10.017.Google Scholar
Ericson, M. D., Schnell, S. M., Freeman, K. T. & Haskell-Luevano, C. (2015) A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist. Bioorganic & Medicinal Chemistry Letters 25(22):5306–308. Available at: http://dx.doi.org/10.1016/j.bmcl.2015.09.046.Google Scholar
Fetissov, S. O., Hamze Sinno, M., Coëffier, M., Bole-Feysot, C., Ducrotté, P., Hökfelt, T. & Déchelotte, P. (2008) Autoantibodies against appetite-regulating peptide hormones and neuropeptides: Putative modulation by gut microflora. Nutrition 24(4):348–59. Available at: http://www.sciencedirect.com/science/article/B6TB0-4RSRR1P-1/2/e54c334156f121b0ec526a69b603506f.Google Scholar
Fetissov, S. O., Harro, J., Jaanisk, M., Järv, A., Podar, I., Allik, J., Nilsson, I., Sakthivel, P., Lefvert, A. K. & Hökfelt, T. (2005) Autoantibodies against neuropeptides are associated with psychological traits in eating disorders. Proceedings of the National Academy of Sciences USA 102(41):14865–70.Google Scholar
Fetissov, S. O., Legrand, R. & Lucas, N. (2019) Bacterial protein mimetic of peptide hormone as a new class of protein-based drugs. Current Medicinal Chemistry 26(3):546–53. Available at: https://doi.org/10.2174/0929867324666171005110620.Google Scholar
François, M., Schaefer, J. M., Bole-Feysot, C., Déchelotte, P., Verhulst, F. C. & Fetissov, S. O. (2015) Ghrelin-reactive immunoglobulins and anxiety, depression and stress-induced cortisol response in adolescents. The TRAILS study. Progress in Neuro-Psychopharmacology 59:1–7. Available at: http://dx.doi.org/10.1016/j.pnpbp.2014.12.011.Google Scholar
Garcia, F. D., Coquerel, Q., do Rego, J.-C., Cravezic, A., Bole-Feysot, C., Kiive, E., Déchelotte, P., Harro, J. & Fetissov, S. O. (2012) Anti-neuropeptide Y plasma immunoglobulins in relation to mood and appetite in depressive disorder. Psychoneuroendocrinology 37:1457–67. Available at: http://www.sciencedirect.com/science/article/pii/S0306453012000522.Google Scholar
Garcia, F. D., Coquerel, Q., Kiive, E., Déchelotte, P., Harro, J. & Fetissov, S. O. (2011) Autoantibodies reacting with vasopressin and oxytocin in relation to cortisol secretion in mild and moderate depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry 35(1):118–25. Available at: http://www.sciencedirect.com/science/article/B6TBR-515SRKJ-1/2/799ec6a29b3a8757aa79b210e93426f0.Google Scholar
Hökfelt, T., Bartfai, T. & Bloom, F. (2003) Neuropeptides: Opportunities for drug discovery. Lancet Neurology 2(8):463–72. Available at: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12878434.Google Scholar
Karaiskos, D., Mavragani, C. P., Sinno, M. H., Déchelotte, P., Zintzaras, E., Skopouli, F. N., Fetissov, S. O. & Moutsopoulos, H. M. (2010) Psychopathological and personality features in primary Sjogren's syndrome – Associations with autoantibodies to neuropeptides. Rheumatology 49(9):1762–69. Available at: http://rheumatology.oxfordjournals.org/cgi/content/abstract/keq158v1.Google Scholar
Lucas, N., Legrand, R., Bôle-Feysot, C., Breton, J., Coëffier, M., Akkermann, K., Järv, A., Harro, J., Déchelotte, P. & Fetissov, S. O. (2019) Immunoglobulin G modulation of the melanocortin 4 receptor signaling in obesity and eating disorders. Translational Psychiatry 9(1): Article number 87. Available at: https://doi.org/10.1038/s41398-019-0422-9.Google Scholar
Mogk, A., Deuerling, E., Vorderwulbecke, S., Vierling, E. & Bukau, B. (2003) Small heat shock proteins, ClpB and the DnaK system form a functional triade in reversing protein aggregation. Molecular Microbiology 50(2):585–95. Available at: http://www.ncbi.nlm.nih.gov/pubmed/14617181.Google Scholar
Takagi, K., Legrand, R., Asakawa, A., Amitani, H., François, M., Tennoune, N., Coëffier, M., Claeyssens, S., do Rego, J.-C., Déchelotte, P., Inui, A. & Fetissov, S. O. (2013) Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans. Nature Communications 4:2685.Google Scholar
Tennoune, N., Chan, P., Breton, J., Legrand, R., Chabane, Y. N., Akkermann, K., Jarv, A., Ouelaa, W., Takagi, K., Ghouzali, I., François, M., Lucas, N., Bole-Feysot, C., Pestel-Caron, M., do Rego, J.C., Vaudry, D., Harro, J., Dé, E., Déchelotte, P. & Fetissov, S. O. (2014) Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide [alpha]-MSH, at the origin of eating disorders. Translational Psychiatry 4:e458. Available at: https://doi.org/10.1038/tp.2014.98.Google Scholar
Værøy, H., Adori, C., Legrand, R., Lucas, N., Breton, J., Cottard, C., do Rego, J.-C., Duparc, C., Louiset, E., Lefebvre, H., Déchelotte, P., Western, E., Andersson, S., Hökfelt, T. & Fetissov, S. O. (2018) Autoantibodies reactive to adrenocorticotropic hormone can alter cortisol secretion in both aggressive and nonaggressive humans. Proceedings of the National Academy of Sciences USA 115(28):E6576–84. Available at: https://doi.org/10.1073/pnas.1720008115.Google Scholar