Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-5c6d5d7d68-vt8vv Total loading time: 0.001 Render date: 2024-08-09T21:00:54.993Z Has data issue: false hasContentIssue false

Chapter 9 - Donor-Specific Anti-Human Leukocyte Antigen Antibodies and Risk of Graft Failure after Hematopoietic Cell Transplants

from Section 2 - Donor Selection for Allogeneic Hematopoietic Cell Transplants: A Moving Target

Published online by Cambridge University Press:  24 May 2017

By
Marcelo A. Fernández-Viña  and
Stefan O. Ciurea
Edited by
Hillard M. Lazarus ,
Robert Peter Gale ,
Armand Keating ,
Andrea Bacigalupo ,
Reinhold Munker  and
Kerry Atkinson
Edited in association with
Syed Ali Abutalib
Hillard M. Lazarus
Affiliation:
Case Western Reserve University, Ohio
Robert Peter Gale
Affiliation:
Imperial College London
Armand Keating
Affiliation:
University of Toronto
Andrea Bacigalupo
Affiliation:
Ospedale San Martino, Genoa
Reinhold Munker
Affiliation:
Louisiana State University, Shreveport
Kerry Atkinson
Affiliation:
University of Queensland
Syed Ali Abutalib
Affiliation:
Midwestern Regional Medical Center, Cancer Treatment Centers of America, Chicago
Get access
Type
Chapter
Information
Hematopoietic Cell Transplants
Concepts, Controversies and Future Directions
 , pp. 73 - 78
Publisher: Cambridge University Press
Print publication year: 2000

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Beatty, PG, Clift, RA, Mickelson, EM, Nisperos, BB, Flournoy, N, Martin, PJ, et al. Marrow transplantation from related donors other than HLA-identical siblings. N Engl J Med. 1985;313(13):765–71.CrossRefGoogle ScholarPubMed
Saber, W, Opie, S, Rizzo, JD, Zhang, MJ, Horowitz, MM, Schriber, J. Outcomes after matched unrelated donor versus identical sibling hematopoietic cell transplantation in adults with acute myelogenous leukemia. Blood. 2012;119(17):3908–16.CrossRefGoogle ScholarPubMed
Arora, M, Weisdorf, DJ, Spellman, SR, Haagenson, MD, Klein, JP, Hurley, CK, et al. HLA-identical sibling compared with 8/8 matched and mismatched unrelated donor bone marrow transplant for chronic phase chronic myeloid leukemia. J Clin Oncol. 2009;27(10):1644–52.CrossRefGoogle ScholarPubMed
Foeken, LM, Green, A, Hurley, CK, Marry, E, Wiegand, T, Oudshoorn, M. Donor Registries Working Group of the World Marrow Donor Association (WMDA). Monitoring the international use of unrelated donors for transplantation: the WMDA annual reports. Bone Marrow Transplant. 2010;45(5):811–8.CrossRefGoogle Scholar
Petz, LD, Spellman, SS, Gragert, L. The underutilization of cord blood transplantation: extent of the problem, causes, and methods improvement. In Broxmeyer, HE, ed. Cord Blood: Biology, Transplantation, Banking, and Regulation. Bethesda, MD: AABB Press; 2011: 557–84.Google Scholar
Flomenberg, N, Baxter-Lowe, LA, Confer, D, Fernandez-Vina, M, Filipovich, A, Horowitz, M, et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood. 2004;104(7):1923–30.CrossRefGoogle Scholar
Cutler, C, Kim, HT, Sun, L, Sese, D, Glotzbecker, B, Armand, P, et al. Donor-specific anti-HLA antibodies predict outcome in double umbilical cord blood transplantation. Blood. 2011;118(25):6691–7.CrossRefGoogle ScholarPubMed
Takanashi, M, Atsuta, Y, Fujiwara, K, Kodo, H, Kai, S, Sato, H, et al. The impact of anti-HLA antibodies on unrelated cord blood transplantations. Blood. 2010;116(15):2839–46.CrossRefGoogle ScholarPubMed
Ciurea, SO, de Lima, M, Cano, P, Korbling, M, Giralt, S, Shpall, EJ, et al. High risk of graft failure in patients with anti-HLA antibodies undergoing haploidentical stem-cell transplantation. Transplantation. 2009;88(8):1019–24.CrossRefGoogle ScholarPubMed
Spellman, S, Bray, R, Rosen-Bronson, S, Haagenson, M, Klein, J, Flesch, S, et al. The detection of donor-directed, HLA-specific alloantibodies in recipients of unrelated hematopoietic cell transplantation is predictive of graft failure. Blood. 2010;115(13):2704–8.CrossRefGoogle ScholarPubMed
Ciurea, SO, Thall, PF, Wang, X, Wang, SA, Hu, Y, Cano, P, et al. Donor-specific anti-HLA Abs and graft failure in matched unrelated donor hematopoietic stem cell transplantation. Blood. 2011;118(22):5957–64.CrossRefGoogle ScholarPubMed
Patel, R, Terasaki, PI. Significance of the positive crossmatch test in kidney transplantation. N Engl J Med. 1969;280(14):735–9.CrossRefGoogle ScholarPubMed
Held, PJ, Kahan, BD, Hunsicker, LG, Liska, D, Wolfe, RA, Port, FK, et al. The impact of HLA mismatches on the survival of first cadaveric kidney transplants. N Engl J Med. 1994;331(12):765–70.CrossRefGoogle ScholarPubMed
Suciu-Foca, N, Reed, E, Marboe, C, Harris, P, Yu, PX, Sun, YK, et al. The role of anti-HLA antibodies in heart transplantation. Transplantation. 1991;51(3):716–24.CrossRefGoogle ScholarPubMed
Terasaki, PI, Ozawa, M. Predicting kidney graft failure by HLA antibodies: a prospective trial. Am J Transplant. 2004;4(3):438–43.CrossRefGoogle ScholarPubMed
Mao, Q, Terasaki, PI, Cai, J, Briley, K, Catrou, P, Haisch, C, Rebellato, L. Extremely high association between appearance of HLA antibodies and failure of kidney grafts in a five-year longitudinal study. Am J Transplant. 2007;7(4):864–71.CrossRefGoogle Scholar
McKenna, RM, Takemoto, SK, Terasaki, PI. Anti-HLA antibodies after solid organ transplantation. Transplantation. 2000;69(3):319–26.CrossRefGoogle ScholarPubMed
Bray, RA, Nolen, JD, Larsen, C, Pearson, T, Newell, KA, Kokko, K, et al. Transplanting the highly sensitized patient: The Emory algorithm. Am J Transplant. 2006;6(10):2307–15.CrossRefGoogle ScholarPubMed
Anasetti, C, Amos, D, Beatty, PG, Appelbaum, FR, Bensinger, W, Buckner, CD, et al. Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma. N Engl J Med. 1989;320(4):197–204.CrossRefGoogle ScholarPubMed
Ottinger, HD, Rebmann, V, Pfeiffer, KA, Beelen, DW, Kremens, B, Runde, V, et al. Positive serum crossmatch as predictor for graft failure in HLA-mismatched allogeneic blood stem cell transplantation. Transplantation. 2002;73(8):1280–5.CrossRefGoogle ScholarPubMed
Pei, R, Lee, JH, Shih, NJ, Chen, M, Terasaki, PI. Single human leukocyte antigen flow cytometry beads for accurate identification of human leukocyte antigen antibody specificities. Transplantation. 2003;75(1):43–9.CrossRefGoogle ScholarPubMed
Zachary, AA, Leffell, MS. Detecting and monitoring human leukocyte antigen-specific antibodies. Hum Immunol. 2008;69(10):591–604.CrossRefGoogle ScholarPubMed
Gebel, HM, Liwski, RS, Bray, RA. Technical aspects of HLA antibody testing. Curr Opin Organ Transplant. 2013;18(4):455–62.CrossRefGoogle ScholarPubMed
Mignot, E, Thorsby, E. Narcolepsy and the HLA system. N Engl J Med. 2001;344(9):692.CrossRefGoogle ScholarPubMed
Kwok, WW, Kovats, S, Thurtle, P, Nepom, GT. HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation. J Immunol. 1993;150(6):2263–72.CrossRefGoogle ScholarPubMed
Bodmer, J, Bodmer, W, Heyes, J, So, A, Tonks, S, Trowsdale, J, Young, J. Identification of HLA-DP polymorphism with DP alpha and DP beta probes and monoclonal antibodies: correlation with primed lymphocyte typing. Proc Natl Acad Sci U S A. 1987;84(13):4596–600.CrossRefGoogle ScholarPubMed
Klohe, E, Pistillo, MP, Ferrara, GB, Goeken, NE, Greazel, NS, Karr, RW. Critical role of HLA-DR beta 1 residue 58 in multiple polymorphic epitopes recognized by xenogeneic and allogeneic antibodies. Hum Immunol. 1992;35(1):18–28.CrossRefGoogle ScholarPubMed
Cano, P, Fernández-Viña, M. Two sequence dimorphisms of DPB1 define the immunodominant serologic epitopes of HLA-DP. Hum Immunol. 2009;70(10):836–43.CrossRefGoogle ScholarPubMed
El-Awar, N, Lee, JH, Tarsitani, C, Terasaki, PI. HLA class I epitopes: recognition of binding sites by mAbs or eluted alloantibody confirmed with single recombinant antigens. Hum Immunol. 2007;68(3):170–80.CrossRefGoogle ScholarPubMed
Deeg, HJ, Storb, R, Weiden, PL, Shulman, HM, Graham, TC, Torok-Storb, BJ, Thomas, ED. Abrogation of resistance to and enhancement of DLA-nonidentical unrelated marrow grafts in lethally irradiated dogs by thoracic duct lymphocytes. Blood. 1979;53(4):552–7.CrossRefGoogle ScholarPubMed
Ciurea, SO, Saliba, RM, Hamerschlak, N, Karduss Aurueta, AJ, Bassett, R, Fernandez-Vina, M, et al. Fludarabine, melphalan, thiotepa and anti-thymocyte globulin conditioning for unrelated cord blood transplant. Leuk Lymphoma. 2012;53(5):901–6.CrossRefGoogle ScholarPubMed
Chen, G, Tyan, DB. C1q assay for the detection of complement fixing antibody to HLA antigens. Methods Mol Biol. 2013;1034:305–11.CrossRefGoogle ScholarPubMed
Loupy, A, Lefaucheur, C, Vernerey, D, Prugger, C, Duong van Huyen, JP, Mooney, N, et al. Complement-binding anti-HLA antibodies and kidney-allograft survival. N Engl J Med. 2013;369(13):1215–26.CrossRefGoogle ScholarPubMed
Ciurea, SO, Thall, PF Milton, DR, et al. Complement-binding donor-specific anti-HLA antibodies and risk of primary graft failure in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2015;21(8):1392–8.CrossRefGoogle ScholarPubMed
Leffell, MS, Jones, RJ, Gladstone, DE. Donor HLA-specific Abs: to BMT or not to BMT? Bone Marrow Transplant. 2015 Feb 23. doi: 10.1038/bmt.2014.331. [Epub ahead of print].CrossRefGoogle Scholar
Marfo, K, Lu, A, Ling, M, Akalin, E. Desensitization protocols and their outcome. Clin J Am Soc Nephrol. 2011;6(4):922–36.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×