Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-7479d7b7d-c9gpj Total loading time: 0 Render date: 2024-07-09T05:07:16.504Z Has data issue: false hasContentIssue false

5 - Schizoaffective Disorder

from Part II - Primary Psychotic Disorders

Published online by Cambridge University Press:  06 January 2010

By
Daniel J. Abrams  and
David B. Arciniegas
Edited by
Daryl Fujii  and
Iqbal Ahmed
Daniel J. Abrams
Affiliation:
University of Colorado School of Medicine
David B. Arciniegas
Affiliation:
University of Colorado School of Medicine, Denver, CO
Daryl Fujii
Affiliation:
University of Hawaii, Manoa
Iqbal Ahmed
Affiliation:
University of Hawaii, Manoa
Get access

Summary

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Chapter
Information
The Spectrum of Psychotic Disorders
Neurobiology, Etiology and Pathogenesis
 , pp. 78 - 95
Publisher: Cambridge University Press
Print publication year: 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Angst, J., Felder, W., & Lohmeyer, B. (1980). Course of schizoaffective psychoses: Results of a followup study. Schizophrenia Bulletin, 6(4), 579–85.Google Scholar
Angst, J., & Preisig, M. (1995). Course of a clinical Cohort of unipolar, bipolar and schizoaffective patients. Results of a prospective study from 1959 to 1985. Schweizer Archiv fur Neurologie and Psychiatrie, 146(1), 5–16.Google Scholar
Ardekani, B. A., Nierenberg, J., Hoptman, M. J., et al. (2003). MRI study of white matter diffusion anisotropy in schizophrenia. Neuroreport, 14(16), 2025–9.Google Scholar
Baethge, C., Gruschka, P., Berghofer, A., et al. (2004). Prophylaxis of schizoaffective disorder with lithium or carbamazepine: Outcome after long-term follow-up. Journal of Affective Disorders, 79(1–3), 43–50.Google Scholar
Benabarre, A., Vieta, E., Colom, F., et al. (2001). Bipolar disorder, schizoaffective disorder and schizophrenia: Epidemiologic, clinical and prognostic differences. European Psychiatry, 16(3), 167–72.Google Scholar
Benson, K. L., Sullivan, E. V., Lim, K. O., et al. (1996). Slow wave sleep and computed tomographic measures of brain morphology in schizophrenia. Psychiatry Research, 60(2–3), 125–34.Google Scholar
Berner, P. & Simhandl, C. (1983). Approaches to an exact definition of schizo-affective psychoses for research purposes. Psychiatria Clinica (Basel), 16(2–4), 245–53.Google Scholar
Bilder, R. M., Goldman, R. S., Volavka, J., et al. (2002). Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder. American Journal of Psychiatry, 159(6), 1018–28.Google Scholar
Borenstein, S., Cheron, G., Toscano-Aguilar, M., et al. (1988). Comparative study of the amplitude, surface and duration of the pre- and post-imperative waves of the CNV (contingent negative variation) in a group of 40 schizophrenic and schizo-affective patients as compared with normal subjects. Neurophysiologie Clinique, 18(2), 129–40.Google Scholar
Boutros, N., Nasrallah, H., Leighty, R., et al. (1997). Auditory evoked potentials, clinical vs. research applications. Psychiatry Research, 69(2–3), 183–95.Google Scholar
Brenner, C. A., Sporns, O., Lysaker, P. H., et al. (2003). EEG synchronization to modulated auditory tones in schizophrenia, schizoaffective disorder, and schizotypal personality disorder, American Journal of Psychiatry, 160(12), 2238–40.Google Scholar
Bruder, G., Kayser, J., Tenke, C., et al. (1998). The time course of visuospatial processing deficits in schizophrenia: An event-related brain potential study. Journal of Abnormal Psychology, 107(3), 399–411.Google Scholar
Bryson, G., Bell, M., & Lysaker, P. (1997). Affect recognition in schizophrenia: A function of global impairment or a specific cognitive deficit. Psychiatry Research, 71(2), 105–13.Google Scholar
Bryson, G., Greig, T., Lysaker, P., et al. (2002). Longitudinal Wisconsin card sorting performance in schizophrenia patients in rehabilitation. Applied Neuropsychology, 9(4), 203–9.Google Scholar
Buchanan, R. W., Francis, A., Arango, C., et al. (2004). Morphometric assessment of the heteromodal association cortex in schizophrenia. American Journal of Psychiatry, 161(2), 322–31.Google Scholar
Cannon, T. D., Erp, T. G., Rosso, I. M., et al. (2002). Fetal hypoxia and structural brain abnormalities in schizophrenic patients, their siblings, and controls. Archives of General Psychiatry, 59(1), 35–41.Google Scholar
Davis, J. M. & Chen, N. (2004). Dose response and dose equivalence of antipsychotics. Journal of Clinical Psychopharmacology, 24(2), 192–208.Google Scholar
Dell'Osso, L., Akiskal, H. S., Freer, P.et al. (1993). Psychotic and nonpsychotic bipolar mixed states: Comparisons with manic and Schizoaffective disorders. European Archives of Psychiatry and Clinical NeuroScience, 243(2), 75–81.Google Scholar
del Rio Vega, J. M. & Ayuso-Gutierrez, J. L. (1990). Course of schizoaffective psychosis: A retrospective study. Acta Psychiatrica Scandinavica, 81(6), 534–7.Google Scholar
del Rio Vega, J. M. & Ayuso-Gutierrez, J. L. (1992). Course of schizoaffective psychosis: Further data from a retrospective study. Acta Psychiatrica Scandinavica, 85(5), 328–30.Google Scholar
Dick, D. M., Foroud, T., Flury, L., et al. (2003). Genomewide linkage analyses of bipolar disorder: A new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative. American Journal of Human Genetics, 73(1), 107–14.Google Scholar
Fabisch, K., Fabisch, H., Langs, G., et al. (2001). Basic symptoms and their contribution to the differential typology of acute schizophrenic and schizoaffective disorders. Psychopathology, 34(1), 15–22.Google Scholar
Faustman, W. O., Bardgett, M., Faull, K. F., et al. (1999). Cerebrospinal fluid glutamate inversely correlates with positive symptom severity in unmedicated male schizophrenic/schizoaffective patients. Biological Psychiatry, 45(1), 68–75.Google Scholar
Fogelson, D. L., Nuechterlein, K. H., Asarnow, R. F., et al. (1991). Interrater reliability of the Structured Clinical Interview for DSM-III-R, Axis II: Schizophrenia spectrum and affective spectrum disorders. Psychiatry Research, 39(1), 55–63.Google Scholar
Friedlander, R. I. & Donnelly, T. (2004). Early-onset psychosis in youth with intellectual disability. Journal of Intellectual Disability Research, 48(6), 540–7.Google Scholar
Giouzeli, M., Williams, N. A., Lonie, L. J., et al. (2004). ProtocadherinX/Y, a candidate gene-pair for schizophrenia and schizoaffective disorder: A DHPLC investigation of genomic sequence. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 129(1), 1–9.Google Scholar
Goldstein, G., Shemansky, W. J., & Allen, D. N. (2005). Cognitive function in schizoaffective disorder and clinical subtypes of schizophrenia. Archives of Clinical Neuropsychology, 20(2), 153–9.Google Scholar
Gooding, D. C. & Tallent, K. A. (2002). Spatial working memory performance in patients with schizoaffective psychosis versus schizophrenia: A tale of two disorders?, Schizophrenia Research, 53(3), 209–18.Google Scholar
Harrow, M., Grossman, L. S., Herbener, E. S., et al. (2000). Ten-year outcome: Patients with schizoaffective disorders, schizophrenia, affective disorders and mood-incongruent psychotic symptoms. British Journal of Psychiatry, 177, 421–6.Google Scholar
Harvey, P. D., Siu, C. O., & Romano, S. (2004). Randomized, controlled, double-blind, multicenter comparison of the cognitive effects of ziprasidone versus olanzapine in acutely ill inpatients with schizophrenia or schizoaffective disorder. Psychopharmacology (Berlin), 172(3), 324–32.Google Scholar
Hodgkinson, C. A., Goldman, D., Jaeger, J., et al. (2004). Disrupted in schizophrenia 1 (DISC1): Association with schizophrenia, schizoaffective disorder, and bipolar disorder. American Journal of Human Genetics, 75(5), 862–72.Google Scholar
Hollis, C. (2000). Adult outcomes of child- and adolescent-onset schizophrenia: Diagnostic stability and predictive validity. American Journal of Psychiatry, 157(10), 1652–9.Google Scholar
Inui, K., Motomura, E., Okushima, R., et al. (1998). Electroencephalographic findings in patients with DSM-IV mood disorder, schizophrenia, and other psychotic disorders. Biological Psychiatry, 43(1), 69–75.Google Scholar
Kasanin, J. (1994). The acute schizoaffective psychoses. 1933. American Journal of Psychiatry, 151(6 Suppl.), 144–54.Google Scholar
Kathmann, N., Hochrein, A., Uwer, R., et al. (2003). Deficits in gain of smooth pursuit eye movements in schizophrenia and affective disorder patients and their unaffected relatives. American Journal of Psychiatry, 160(4), 696–702.Google Scholar
Kayser, J., Bruder, G. E., Friedman, D., et al. (1999). Brain event-related potentials (ERPs) in schizophrenia during a word recognition memory task. International Journal of Psychophysiology, 34(3), 249–65.Google Scholar
Kayser, J., Bruder, G. E., Tenke, C. E., et al. (2001). Event-related brain potentials (ERPs) in schizophrenia for tonal and phonetic oddball tasks. Biological Psychiatry, 49(10), 832–47.Google Scholar
Keck, P. E. Jr., McElroy, S. L., & Strakowski, S. M. (1996). New developments in the pharmacologic treatment of schizoaffective disorder. Journal of Clinical Psychiatry, 57(Suppl. 9), 41–8.Google Scholar
Keshavan, M. S., Stanley, J. A., Montrose, D. M., et al. (2003). Prefrontal membrane phospholipid metabolism of child and adolescent offspring at risk for schizophrenia or schizoaffective disorder: An in vivo 31P MRS study. Molecular Psychiatry, 8(3), 251, 316–23.Google Scholar
Kirov, G., Ivanov, D., Williams, N. M., et al. (2004). Strong evidence for association between the dystrobrevin binding protein 1 gene (DTNBP1) and schizophrenia in 488 parent-offspring trios from Bulgaria. Biological Psychiatry, 55(10), 971–5.Google Scholar
Kumar, N. & Debruille, J. B. (2004). Semantics and N400: Insights for schizophrenia. Journal of Psychiatry and Neuroscience, 29(2), 89–98.Google Scholar
Kumar, R., Marks, M., Wieck, A., et al. (1993). Neuroendocrine and psychosocial mechanisms in post-partum psychosis. Progress in Neuropsychopharmacology and Biological Psychiatry, 17(4), 571–9.Google Scholar
Laruelle, M., bi-Dargham, A., Casanova, M. F., et al. (1993). Selective abnormalities of prefrontal serotonergic receptors in schizophrenia. A postmortem study. Archives of General Psychiatry, 50(10), 810–18.Google Scholar
Lenz, G., Simhandl, C., Thau, K., et al. (1991). Temporal stability of diagnostic criteria for functional psychoses. Results from the Vienna follow-up study. Psychopathology, 24(5), 328–35.Google Scholar
Levinson, D. F., Umapathy, C., & Musthaq, M. (1999). Treatment of schizoaffective disorder and schizophrenia with mood symptoms. American Journal of Psychiatry, 156(8), 1138–48.Google Scholar
Liddle, P. F. (2001). Disordered Mind and Brain. London: Gaskell.
Lieberman, J. A., Jody, D., Alvir, J. M., et al. (1993a). Brain morphology, dopamine, and eye-tracking abnormalities in first-episode schizophrenia. Prevalence and clinical correlates. Archives of General Psychiatry, 50(5), 357–68.Google Scholar
Lieberman, J. A., Jody, D., Geisler, S., et al. (1993b). Time course and biologic correlates of treatment response in first-episode schizophrenia. Archives of General Psychiatry, 50(5), 369–76.Google Scholar
Liu, C. M., Hwu, H. G., Fann, C. S., et al. (2005). Linkage evidence of schizophrenia to loci near neuregulin 1 gene on chromosome 8p21 in Taiwanese families. American Journal of Medical Genetic Part B: Neuropsychiatric Genetics, 134(1), 79–83.Google Scholar
Malla, A. K., Norman, R. M., & Scholten, D. (2000). Predictors of service use and social conditions in patients with psychotic disorders. Canadian Journal of Psychiatry, 45(3), 269–73.Google Scholar
Manschreck, T. C., Maher, B. A., Beaudette, S. M., et al. (1997). Context memory in schizoaffective and schizophrenic disorders. Schizophrenia Research, 26(2–3), 153–61.Google Scholar
Marneros, A. (2003). The schizoaffective phenomenon: The state of the art. Acta Psychiatrica Scandinavica Supplementa, 418, 29–33.Google Scholar
Marneros, A., Deister, A., & Rohde, A. (1990a). Psychopathological and social status of patients with affective, schizophrenic and schizoaffective disorders after long-term course. Acta Psychiatrica Scandinavica, 82(5), 352–8.Google Scholar
Marneros, A., Deister, A., & Rohde, A. (1990b). Sociodemographic and premorbid features of schizophrenic, schioaffective and affective psychoses. In Affective and Schizoaffective Disorders: Similarities and Differences, ed. Marneros, A. & Tsuang, D.. Heidelberg: Springer Verlag, pp. 23–33.
Marneros, A., Deister, A., & Rohde, A. (1991). Stability of diagnoses in affective, schizoaffective and schizophrenic disorders. Cross-sectional versus longitudinal diagnosis. European Archives of Psychiatry and Clinical Neuroscience, 241(3), 187–92.Google Scholar
Marneros, A., Deister, A., Rohde, A., et al. (1989). Long-term outcome of schizoaffective and schizophrenic disorders: A comparative study. I. Definitions, methods, psychopathological and social outcome. European Archives of Psychiatry and Neurological Science, 238(3), 118–25.Google Scholar
McClellan, J. & McCurry, C. (1999). Early onset psychotic disorders: Diagnostic stability and clinical characteristics. European Child and Adolescent Psychiatry, 8(Suppl. 1), I13–I19.Google Scholar
Meltzer, H. Y., Arora, R. C., & Metz, J. (1984). Biological studies of schizoaffective disorders. Schizophrenia Bulletin, 10(1), 49–70.Google Scholar
Mitrushina, M., Abara, J., & Blumenfeld, A. (1996). A comparison of cognitive profiles in schizophrenia and other psychiatric disorders. Journal of Clinical Psychology, 52(2), 177–90.Google Scholar
Mokrani, M., Duval, F., Diep, T. S., et al. (2000). Multihormonal responses to clonidine in patients with affective and psychotic symptoms. Psychoneuroendocrinology, 25(7), 741–52.Google Scholar
Nolen, W. A., Luckenbaugh, D. A., Altshuler, L. L., et al. (2004). Correlates of 1-year prospective outcome in bipolar disorder: Results from the Stanley Foundation Bipolar Network. American Journal of Psychiatry, 161(8), 1447–54.Google Scholar
Olincy, A. & Martin, L. (2005). Diminished suppression of the P50 auditory evoked potential in bipolar disorder subjects with a history of psychosis. American Journal of Psychiatry, 162(1), 43–9.Google Scholar
Prasad, K. M., Rohm, B. R., & Keshavan, M. S. (2004). Parahippocampal gyrus in first episode psychotic disorders: A structural magnetic resonance imaging study. Progress in Neuropsychopharmacology and Biological Psychiatry, 28(4), 651–8.Google Scholar
Reite, M., Teale, P., Rojas, D. C., et al. (1999). Schizoaffective disorder: Evidence for reversed cerebral asymmetry. Biological Psychiatry, 46(1), 133–6.Google Scholar
Schwartz, J. E., Fennig, S., Tanenberg-Karant, M., et al. (2000). Congruence of diagnoses 2 years after a first-admission diagnosis of psychosis. Archives of General Psychiatry, 57(6), 593–600.Google Scholar
Scully, P. J., Owens, J. M., Kinsella, A., et al. (2004). Schizophrenia, schizoaffective and bipolar disorder within an epidemiologically complete, homogeneous population in rural Ireland: Small area variation in rate. Schizophrenia Research, 67(2–3), 143–55.Google Scholar
Segurado, R., tera-Wadleigh, S. D., Levinson, D. F., et al. (2003). Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. American Journal of Human Genetics, 73(1), 49–62.Google Scholar
Sharma, R. P., Javaid, J. I., Davis, J. M., et al. (1998). Pretreatment plasma homovanillic acid in schizophrenia and schizoaffective disorder: The influence of demographic variables and the inpatient drug-free period. Biological Psychiatry, 44(6), 488–92.Google Scholar
Skol, A. D., Young, K. A., Tsuang, D. W., et al. (2003). Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large Veterans Affairs Cooperative Study sample. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 118(1), 8–15.Google Scholar
Spitzer, R. L., Endicott, J., & Robins, E. (1978). Research diagnostic criteria: Rationale and reliability. Archives of General Psychiatry, 35(6), 773–82.Google Scholar
Staddon, S., Arranz, M. J., Mancama, D., et al. (2005). Association between dopamine D3 receptor gene polymorphisms and schizophrenia in an isolate population. Schizophrenia Research, 73(1), 49–54.Google Scholar
Stieglitz, R. D. & Helmchen, H. (1990). Schizoaffective disorders in clinical routine: Symptomatology, etiology, and course. In Affective and Schizoaffective Disorders: Similarities and Differences, ed. Marneros, A. & Tsuang, D.. Heidelberg: Springer Verlag, 53–71.
Stip, E., Sepehry, A. A., Prouteau, A., et al. (2005). Cognitive discernible factors between schizophrenia and schizoaffective disorder. Brain and Cognition, 59(3), 292–5.Google Scholar
Stone, W. S., Thermenos, H. W., Tarbox, S. I., et al. (2005). Medial temporal and prefrontal lobe activation during verbal encoding following glucose ingestion in schizophrenia: A pilot fMRI study. Neurobiology of Learning and Memory, 83(1), 54–64.Google Scholar
Szeszko, P. R., Ardekani, B. A., Ashtari, M., et al. (2005). White matter abnormalities in first-episode schizophrenia or schizoaffective disorder: A diffusion tensor imaging study. American Journal of Psychiatry, 162(3), 602–5.Google Scholar
Taylor, M. A. & Amir, N. (1994). Are schizophrenia and affective disorder related? The problem of schizoaffective disorder and the discrimination of the psychoses by signs and symptoms. Comprehensive Psychiatry, 35(6), 420–9.Google Scholar
Teale, P., Reite, M., Rojas, D. C., et al. (2000). Fine structure of the auditory M100 in schizophrenia and schizoaffective disorder. Biological Psychiatry, 48(11), 1109–12.Google Scholar
Tohen, M., Strakowski, S. M., Zarate, C. Jr., et al. (2000). The McLean-Harvard first-episode project: 6-month symptomatic and functional outcome in affective and nonaffective psychosis. Biological Psychiatry, 48(6), 467–76.Google Scholar
Tohen, M., Zhang, F., Keck, P. E., et al. (2001). Olanzapine versus haloperidol in schizoaffective disorder, bipolar type. Journal of Affective Disorders, 67(1–3), 133–40.Google Scholar
Ujike, H., Takehisa, Y., Takaki, M., et al. (2001). NOTCH4 gene polymorphism and susceptibility to schizophrenia and schizoaffective disorder. Neuroscience Letters, 301(1), 41–4.Google Scholar
Erp, T. G., Saleh, P. A., Rosso, I. M., et al. (2002). Contributions of genetic risk and fetal hypoxia to hippocampal volume in patients with schizophrenia or schizoaffective disorder, their unaffected siblings, and healthy unrelated volunteers. American Journal of Psychiatry, 159(9), 1514–20.Google Scholar
Vieta, E., Herraiz, M., Fernandez, A., et al. (2001). Efficacy and safety of risperidone in the treatment of schizoaffective disorder: Initial results from a large, multicenter surveillance study. Group for the Study of Risperidone in Affective Disorders (GSRAD). Journal of Clinical Psychiatry, 62(8), 623–30.Google Scholar
Werry, J. S., McClellan, J. M., & Chard, L. (1991). Childhood and adolescent schizophrenic, bipolar, and schizoaffective disorders: A clinical and outcome study. Journal of American Academy of Child and Adolescent Psychiatry, 30(3), 457–65.Google Scholar
Whaley, A. L. (2002). Symptom clusters in the diagnosis of affective disorder, schizoaffective disorder, and schizophrenia in African Americans. Journal of the National Medical Association, 94(5), 313–19.Google Scholar
Wijsman, E. M., Rosenthal, E. A., Hall, D., et al. (2003). Genome-wide scan in a large complex pedigree with predominantly male schizophrenics from the island of Kosrae: Evidence for linkage to chromosome 2q. Molecular Psychiatry, 8 (7), 643, 695–705.Google Scholar
Winokur, A., Black, D. W., & Nasrallah, A. (1990). The schizoaffective continuum. In Affective and Schizoaffective Disorders: Similarities and Differences, ed. Marneros, A. & Tsuang, D.. Heidelberg: Springer Verlag, pp. 23–33.
Zarate, C. A. Jr., Tohen, M., Baraibar, G., et al. (1997). Shifts in hospital diagnostic frequencies: Bipolar disorder subtypes, 1981–1993. Journal of Affective Disorders, 43(1), 79–84.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×