Book contents
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Section 2 Human Nervous System Development
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Cellular Responses
- Chapter 29 Neuronal Death
- Chapter 30 Macroglial Reactions
- Chapter 31 Inflammatory Responses
- Gray Matter
- White Matter
- Germinal Matrix
- Cerebellum
- Section 5 Malformations
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Chapter 29 - Neuronal Death
from Cellular Responses
Published online by Cambridge University Press: 07 August 2021
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Section 2 Human Nervous System Development
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Cellular Responses
- Chapter 29 Neuronal Death
- Chapter 30 Macroglial Reactions
- Chapter 31 Inflammatory Responses
- Gray Matter
- White Matter
- Germinal Matrix
- Cerebellum
- Section 5 Malformations
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Summary
The idea that loss of neurons could be associated with disease states and that certain microscopic appearances could be indicative of these arose in the mid to late 1800s. If neurons die, become dysfunctional, or are disconnected following a challenge, functionality of the affected neural circuit is compromised. Depending on the magnitude and localization, this may have relatively mild consequences (such as a learning deficit) or major consequences (such as developmental delay, epilepsy, cerebral palsy, or death). We are interested in selective or regional neuron death because they can help to explain the neurologic dysfunction experienced by an individual or give insight into the pathologic process that preceded death.
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- Perinatal Neuropathology , pp. 145 - 154Publisher: Cambridge University PressPrint publication year: 2021