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Chapter 31 - Inflammatory Responses

from Cellular Responses

Published online by Cambridge University Press:  07 August 2021

Mirna Lechpammer ,
Marc Del Bigio  and
Rebecca Folkerth
By
Marc Del Bigio
Mirna Lechpammer
Affiliation:
New York University School of Medicine
Marc Del Bigio
Affiliation:
University of Manitoba, Canada
Rebecca Folkerth
Affiliation:
New York University School of Medicine
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Summary

The development of the human immune system and responses have been reviewed in detail by others (1–3). Monocytes/macrophages, the earliest circulating immune cells, appear at the beginning of the fetal period. They are followed by neutrophils, lymphocyte precursors, and natural killer (NK) cells by gestational week 8–10, and then naïve T and B lymphocytes at week 12. The thymus (the source of T cells) grows rapidly during gestational weeks 7–14 and continues to grow, reaching its maximum size by the end of the first year of life, after which it involutes eventually replaced by fat at puberty (4).

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Perinatal Neuropathology , pp. 159 - 164
Publisher: Cambridge University Press
Print publication year: 2021

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