This chapter covers definitions and characteristics, ultrasound assessment, investigations, counselling and management of fetal anomalies encountered in the second and third trimesters. The chapter has seven sections (head and neck, fetal heart, thoracic and pulmonary abnormalities, spine, abdomen, genitourinary tract and skeletal abnormalities). All sections are richly illustrated with ultrasound pictures, X-ray fetograms and pathological specimens.